Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats

2009 ◽  
Vol 30 (9) ◽  
pp. 551-555 ◽  
Author(s):  
Qiao Wang ◽  
Guoshen Chen
Keyword(s):  
Cerebrospinal Fluid ◽  
Intranasal Administration ◽  
Huperzine A ◽  
Pharmacokinetic Behavior

scholarly journals Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Geetika Nehra ◽  
Shannon Andrews ◽  
Joan Rettig ◽  
Michael N. Gould ◽  
Jill D. Haag ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tumors ◽  
Nasal Mucosa ◽  
Brain Cancer ◽  
Intranasal Administration ◽  
High Performance ◽  
Early Stage ◽  
Plasma Concentrations ◽  
Perillyl Alcohol ◽  
Systemic Absorption

AbstractPerillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been preferred for dosing POH in early-stage clinical trials associated with promising outcomes in primary brain cancer. However, it is unclear how intranasal POH targets brain tumors in these patients. Multiple studies indicate that intranasally applied large molecules may enter the brain and cerebrospinal fluid (CSF) through direct olfactory and trigeminal nerve-associated pathways originating in the nasal mucosa that bypass the blood–brain barrier. It is unknown whether POH, a small molecule subject to extensive nasal metabolism and systemic absorption, may also undergo direct transport to brain or CSF from the nasal mucosa. Here, we compared CSF and plasma concentrations of POH and its metabolite, perillic acid (PA), following intranasal or intravascular POH application. Samples were collected over 70 min and assayed by high-performance liquid chromatography. Intranasal administration resulted in tenfold higher CSF-to-plasma ratios for POH and tenfold higher CSF levels for PA compared to equal dose intravascular administration. Our preclinical results demonstrate POH undergoes direct transport from the nasal mucosa to the CSF, a finding with potential significance for its efficacy as an intranasal chemotherapeutic for brain cancer.

Pharmacokinetics of tramadol in rat plasma and cerebrospinal fluid after intranasal administration

2008 ◽  
Vol 60 (9) ◽  
pp. 1149-1154 ◽  
Author(s):  
Yan Zhao ◽  
Tao Tao ◽  
Jinjin Wu ◽  
Jiaxin Pi ◽  
Ning He ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intranasal Administration ◽  
Rat Plasma

Blood–cerebrospinal fluid barrier to arginine-vasopressin, desmopressin and desglycinamide arginine-vasopressin in the dog

1982 ◽  
Vol 93 (3) ◽  
pp. 319-325 ◽  
Author(s):  
V. T. Y. Ang ◽  
J. S. Jenkins
Keyword(s):  
Cerebrospinal Fluid ◽  
Intravenous Injection ◽  
Arginine Vasopressin ◽  
Half Life ◽  
Intranasal Administration ◽  
Route Of Administration ◽  
Total Plasma ◽  
Intranasal Route ◽  
Plasma Half Life

The passage of 125I-labelled arginine-vasopressin (AVP) and its analogues desmopressin (DDAVP) and desglycinamide arginine-vasopressin (DGAVP) into cerebrospinal fluid (CSF) has been studied in the dog. After intravenous injection or infusion of these peptides radioactive sustances were found in the CSF in amounts ranging from 0·5 to 1·4% of the total plasma radioactivity. However, only DDAVP could be identified in the CSF as the unmetabolized peptide. This observation may be related to the long plasma half-life of DDAVP which was found to be 50 min, compared with a half-life of 13 min for AVP and 8 min for DGAVP. After the intranasal administration of either [3H]AVP or 125I-labelled AVP similar results were obtained. Radioactivity was again present in the CSF but no AVP could be identified. These observations showed that the intranasal route of administration provides no increased access to the CSF. The existence of a blood–CSF barrier to AVP is confirmed and indicates that the concentrations of the hormone normally found in CSF arise from sources other than the blood.

scholarly journals Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Nadine Striepens ◽  
Keith M. Kendrick ◽  
Vanessa Hanking ◽  
Rainer Landgraf ◽  
Ullrich Wüllner ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intranasal Administration ◽  
Blood Concentrations

Huperzine A in rat plasma and CSF following intranasal administration

2007 ◽  
Vol 337 (1-2) ◽  
pp. 127-132 ◽  
Author(s):  
Peng Yue ◽  
Tao Tao ◽  
Yan Zhao ◽  
Jinfeng Ren ◽  
Xuyu Chai
Keyword(s):  
Intranasal Administration ◽  
Rat Plasma ◽  
Huperzine A
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