Genetically engineered stem cell-based strategies for articular cartilage regeneration

2012 ◽  
Vol 59 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Aruna Santhagunam ◽  
Catarina Madeira ◽  
Joaquim M. S. Cabral
Keyword(s):  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Genetically Engineered ◽  
Articular Cartilage Regeneration

In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold

2019 ◽  
Vol 57 ◽  
pp. 49-56 ◽  
Author(s):  
Parviz Vahedi ◽  
Seyedhosein Jarolmasjed ◽  
Hajar Shafaei ◽  
Leila Roshangar ◽  
Jafar Soleimani Rad ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-25
Author(s):  
Shuangpeng Jiang ◽  
Guangzhao Tian ◽  
Xu Li ◽  
Zhen Yang ◽  
Fuxin Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Research Progress ◽  
Therapeutic Effects ◽  
Physical And Mental Health ◽  
Paracrine Effects ◽  
Regeneration Strategies ◽  
Articular Cartilage Regeneration

Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, recent evidence has shown that the stem cell secretome plays an important role in biological processes such as the immune response, inflammation regulation, and drug delivery. At the same time, the stem cell secretome can effectively mediate the process of tissue regeneration. This new theory has attributed the therapeutic effect of stem cells to their paracrine effects. The application of stem cells is not limited to exogenous stem cell transplantation. Endogenous stem cell homing and in situ regeneration strategies have received extensive attention. The application of stem cell derivatives, such as conditioned media, extracellular vesicles, and extracellular matrix, is an extension of stem cell paracrine theory. On the other hand, stem cell pretreatment strategies have also shown promising therapeutic effects. This article will systematically review the latest developments in these areas, summarize challenges in articular cartilage regeneration strategies involving stem cells, and describe prospects for future development.

Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration

Nanoscale ◽  
2017 ◽  
Vol 9 (13) ◽  
pp. 4430-4438 ◽  
Author(s):  
Xiaolin Liu ◽  
Yunlong Yang ◽  
Yan Li ◽  
Xin Niu ◽  
Bizeng Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
In Situ Hydrogel ◽  
Articular Cartilage Regeneration

Materials for Articular Cartilage Regeneration

2012 ◽  
Vol 5 (3) ◽  
pp. 187-199 ◽  
Author(s):  
Aysegul Tombuloglu ◽  
Ayse B. Tekinay ◽  
Mustafa O. Guler
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals The Effect of Supramalleolar Osteotomy without Marrow Stimulation on Cartilage Regeneration for Medial Compartment Ankle Osteoarthritis: Second-Look Arthroscopic Evaluation of Cartilage Regeneration

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0005
Author(s):  
Jung-Won Lim ◽  
Hong-Geun Jung
Keyword(s):  
Patient Satisfaction ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Ankle Arthroscopy ◽  
Medial Compartment ◽  
Ankle Osteoarthritis ◽  
Second Look ◽  
The Mean ◽  
Surface Angle ◽  
Articular Cartilage Regeneration

Category: Ankle Arthritis; Ankle; Arthroscopy Introduction/Purpose: The effect of supramalleolar osteotomy (SMO) without an additional bone marrow-stimulating procedure (BMSP) on articular cartilage regeneration in ankle joint still remains unknown. This study aimed to investigate whether SMO yielded favorable clinical and radiologic outcomes, and to evaluate whether the regeneration of articular cartilage could be observed after SMO without BMSP by second-look arthroscopy. Methods: 43 ankles after SMO (mean follow-up: 35.5 months) were retrospectively reviewed. Visual analog scale (VAS) pain score, American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score, patient satisfaction were used for functional evaluations. The tibial anterior surface angle (TAS) and tibial lateral surface angle (TLS) were measured on radiographs, and ankle osteoarthritis was classified by Takakura stage. Among the 43 patients, 31 underwent ankle arthroscopy prior to SMO, and second-look arthroscopy was performed at 1-year postoperatively. Tibiotalar cartilage regeneration was evaluated according to the modified Outerbridge classification for the 29 patients who had undergone SMO without BMSP. Results: The mean VAS score and AOFAS score significantly improved from 6.4 preoperatively to 1.4 postoperatively and from 61.1 preoperatively to 88.4 postoperatively, respectively (P < 0.05). Regarding overall postoperative patient satisfaction, 18 (41.8%) patients reported their satisfaction as excellent, 23 (53.5%) as satisfied. The mean TAS and TLS significantly improved from 83.8° and 94.8° preoperatively to 78.4° and 82.2° postoperatively, respectively (P < 0.05). 23 out of 28 preoperative Takakura stage IIIa cases and 3 out of 7 IIIb cases improved to postoperative stage II. On second-look arthroscopy, cartilage regeneration of the medial compartment of the tibiotalar joint was observed in 26 of 29 patients (89.7%), whereas cartilage deterioration was not observed in any patient. Conclusion: Medial tibio-talar articular cartilage regeneration was observed in most cases (89.7%) of medial compartment ankle osteoarthritis after SMO without BMSP, which was confirmed with second-look arthroscopic evaluation. It also showed satisfactory clinical and radiologic outcomes with high patient satisfaction.

scholarly journals Biological reconstruction of the joint: Concepts of articular cartilage regeneration and their scientific basis

2021 ◽  
pp. 101718
Author(s):  
Abhishek Vaish ◽  
Saseendar Shanmugasundaram ◽  
Seon Ae Kim ◽  
Dong-Hwan Lee ◽  
Asode Ananthram Shetty ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Scientific Basis ◽  
Biological Reconstruction ◽  
Articular Cartilage Regeneration
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