The adenosine A2Areceptor agonist, CGS 21680, attenuates a probabilistic reversal learning deficit and elevated grooming behavior in BTBR mice

2017 ◽  
Vol 11 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Dionisio A. Amodeo ◽  
Laura Cuevas ◽  
Jeffrey T. Dunn ◽  
John A. Sweeney ◽  
Michael E. Ragozzino
Keyword(s):  
Reversal Learning ◽  
Grooming Behavior ◽  
Learning Deficit ◽  
Cgs 21680 ◽  
Probabilistic Reversal Learning

scholarly journals Impaired probabilistic reversal learning in anxiety: Evidence from behavioral and ERP findings

2021 ◽  
pp. 102751
Author(s):  
Lisheng Xia ◽  
Pengfei Xu ◽  
Ziyan Yang ◽  
Ruolei Gu ◽  
Dandan Zhang
Keyword(s):  
Reversal Learning ◽  
Probabilistic Reversal Learning

Probabilistic Reversal Learning Task

2013 ◽  
Author(s):  
Anna-Maria D'Cruz ◽  
Michael E. Ragozzino ◽  
Matthew W. Mosconi ◽  
Sunil Shrestha ◽  
Edwin H. Cook ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Learning Task ◽  
Probabilistic Reversal Learning

scholarly journals Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis

2020 ◽  
Vol 34 (5) ◽  
pp. 580-583
Author(s):  
Jonathan W Kanen ◽  
Frederique E Arntz ◽  
Robyn Yellowlees ◽  
Rudolf N Cardinal ◽  
Annabel Price ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Negative Feedback ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Serotonin Synthesis ◽  
Male And Female ◽  
Healthy Humans ◽  
Enhanced Sensitivity ◽  
Conventional Analysis ◽  
Probabilistic Reversal Learning

The involvement of serotonin in responses to negative feedback is well established. Acute serotonin reuptake inhibition has enhanced sensitivity to negative feedback (SNF), modelled by behaviour in probabilistic reversal learning (PRL) paradigms. Whilst experiments employing acute tryptophan depletion (ATD) in humans, to reduce serotonin synthesis, have shown no clear effect on SNF, sample sizes have been small. We studied a large sample of healthy volunteers, male and female, and found ATD had no effect on core behavioural measures in PRL. These results indicate that ATD effects can differ from other manipulations of serotonin expected to have a parallel or opposing action.

scholarly journals Impaired probabilistic reversal learning in youths with mood and anxiety disorders

2009 ◽  
Vol 40 (7) ◽  
pp. 1089-1100 ◽  
Author(s):  
D. P. Dickstein ◽  
E. C. Finger ◽  
M. A. Brotman ◽  
B. A. Rich ◽  
D. S. Pine ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Neuropsychological Test ◽  
Affective Neuroscience ◽  
Typically Developing ◽  
Primary Analysis ◽  
Behavioral Deficits ◽  
Learning Impairments ◽  
Response Reversal ◽  
Severe Mood Dysregulation ◽  
Probabilistic Reversal Learning

BackgroundFrom an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls.MethodWe administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7–17 years with BD (n=35), SMD (n=35), ANX (n=42), MDD (n=18) and normal controls (NC; n=35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ.ResultsCompared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p=0.07).ConclusionsOur results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits.

scholarly journals Risperidone and the 5-HT2AReceptor Antagonist M100907 Improve Probabilistic Reversal Learning in BTBR T + tf/J Mice

2014 ◽  
Vol 7 (5) ◽  
pp. 555-567 ◽  
Author(s):  
Dionisio A. Amodeo ◽  
Joshua H. Jones ◽  
John A. Sweeney ◽  
Michael E. Ragozzino
Keyword(s):  
Reversal Learning ◽  
Probabilistic Reversal Learning
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