scholarly journals Risperidone and the 5-HT2AReceptor Antagonist M100907 Improve Probabilistic Reversal Learning in BTBR T + tf/J Mice

2014 ◽  
Vol 7 (5) ◽  
pp. 555-567 ◽  
Author(s):  
Dionisio A. Amodeo ◽  
Joshua H. Jones ◽  
John A. Sweeney ◽  
Michael E. Ragozzino
Keyword(s):  
Reversal Learning ◽  
Probabilistic Reversal Learning

scholarly journals Impaired probabilistic reversal learning in anxiety: Evidence from behavioral and ERP findings

2021 ◽  
pp. 102751
Author(s):  
Lisheng Xia ◽  
Pengfei Xu ◽  
Ziyan Yang ◽  
Ruolei Gu ◽  
Dandan Zhang
Keyword(s):  
Reversal Learning ◽  
Probabilistic Reversal Learning

Probabilistic Reversal Learning Task

2013 ◽  
Author(s):  
Anna-Maria D'Cruz ◽  
Michael E. Ragozzino ◽  
Matthew W. Mosconi ◽  
Sunil Shrestha ◽  
Edwin H. Cook ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Learning Task ◽  
Probabilistic Reversal Learning

scholarly journals Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis

2020 ◽  
Vol 34 (5) ◽  
pp. 580-583
Author(s):  
Jonathan W Kanen ◽  
Frederique E Arntz ◽  
Robyn Yellowlees ◽  
Rudolf N Cardinal ◽  
Annabel Price ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Negative Feedback ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Serotonin Synthesis ◽  
Male And Female ◽  
Healthy Humans ◽  
Enhanced Sensitivity ◽  
Conventional Analysis ◽  
Probabilistic Reversal Learning

The involvement of serotonin in responses to negative feedback is well established. Acute serotonin reuptake inhibition has enhanced sensitivity to negative feedback (SNF), modelled by behaviour in probabilistic reversal learning (PRL) paradigms. Whilst experiments employing acute tryptophan depletion (ATD) in humans, to reduce serotonin synthesis, have shown no clear effect on SNF, sample sizes have been small. We studied a large sample of healthy volunteers, male and female, and found ATD had no effect on core behavioural measures in PRL. These results indicate that ATD effects can differ from other manipulations of serotonin expected to have a parallel or opposing action.

scholarly journals Impaired probabilistic reversal learning in youths with mood and anxiety disorders

2009 ◽  
Vol 40 (7) ◽  
pp. 1089-1100 ◽  
Author(s):  
D. P. Dickstein ◽  
E. C. Finger ◽  
M. A. Brotman ◽  
B. A. Rich ◽  
D. S. Pine ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Neuropsychological Test ◽  
Affective Neuroscience ◽  
Typically Developing ◽  
Primary Analysis ◽  
Behavioral Deficits ◽  
Learning Impairments ◽  
Response Reversal ◽  
Severe Mood Dysregulation ◽  
Probabilistic Reversal Learning

BackgroundFrom an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls.MethodWe administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7–17 years with BD (n=35), SMD (n=35), ANX (n=42), MDD (n=18) and normal controls (NC; n=35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ.ResultsCompared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p=0.07).ConclusionsOur results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits.

scholarly journals Brief Report: Feasibility of the Probabilistic Reversal Learning Task as an Outcome Measure in an Intervention Trial for Individuals with Autism Spectrum Disorder

2021 ◽  
Author(s):  
Lauren M. Schmitt ◽  
John A. Sweeney ◽  
Craig A. Erickson ◽  
Rebecca Shaffer
Keyword(s):  
Autism Spectrum Disorder ◽  
Cognitive Flexibility ◽  
Reversal Learning ◽  
Behavioral Interventions ◽  
Outcome Measure ◽  
Outcome Measurement ◽  
Learning Task ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Probabilistic Reversal Learning

AbstractCognitive flexibility deficits are a hallmark feature of autism spectrum disorder (ASD), but few evidence-based behavioral interventions have successfully addressed this treatment target. Outcome measurement selection may help account for previous findings. The probabilistic reversal learning task (PRL) is a measure of cognitive flexibility previously validated for use in ASD, but its use as an outcome measure has not yet been assessed. The current study examined the feasibility, reproducibility, and sensitivity of PRL in a within-subjects trial of Regulating Together, a group-based intervention targeting emotion regulation. We demonstrated the PRL is highly feasible, showed test–retest reproducibility, and is sensitive to detect change following the intervention. Our findings demonstrate the PRL task may be a useful outcome measure of cognitive flexibility in future intervention trials in ASD.

scholarly journals Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260444
Author(s):  
Matthew Paul Wilkinson ◽  
Chloe Louise Slaney ◽  
Jack Robert Mellor ◽  
Emma Susan Jane Robinson
Keyword(s):  
Reversal Learning ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Learning Task ◽  
Reward Learning ◽  
Feedback Sensitivity ◽  
History Of ◽  
A Current ◽  
Probabilistic Reversal Learning

Early life stress (ELS) is an important risk factor for the development of depression. Impairments in reward learning and feedback sensitivity are suggested to be an intermediate phenotype in depression aetiology therefore we hypothesised that healthy adults with a history of ELS would exhibit reward processing deficits independent of any current depressive symptoms. We recruited 64 adults with high levels of ELS and no diagnosis of a current mental health disorder and 65 controls. Participants completed the probabilistic reversal learning task and probabilistic reward task followed by depression, anhedonia, social status, and stress scales. Participants with high levels of ELS showed decreased positive feedback sensitivity in the probabilistic reversal learning task compared to controls. High ELS participants also trended towards possessing a decreased model-free learning rate. This was coupled with a decreased learning ability in the acquisition phase of block 1 following the practice session. Neither group showed a reward induced response bias in the probabilistic reward task however high ELS participants exhibited decreased stimuli discrimination. Overall, these data suggest that healthy participants without a current mental health diagnosis but with high levels of ELS show deficits in positive feedback sensitivity and reward learning in the probabilistic reversal learning task that are distinct from depressed patients. These deficits may be relevant to increased depression vulnerability.

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