Design and Synthesis of Zn II ‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery

2020 ◽  
Vol 15 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Sourabh Bera ◽  
Abhinanda Chowdhury ◽  
Koushik Sarkar ◽  
Parthasarathi Dastidar
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Design And Synthesis

Viscoelastic Properties of Genetically Engineered Silk-Elastin-Like Protein Polymers

2008 ◽  
Author(s):  
Weibing Teng ◽  
Joseph Cappello ◽  
Xiaoyi Wu
Keyword(s):  
Drug Delivery ◽  
Viscoelastic Properties ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Genetically Engineered ◽  
Structural Proteins ◽  
Design And Synthesis ◽  
Cross Links ◽  
New Protein ◽  
Polypeptide Sequences

Genetic engineering of protein-based materials provides material scientists with high levels of control in material microstructures, properties, and functions [1]. For example, multi-block protein copolymers in which individual block may possess distinct mechanical or biological properties have been biosynthesized [2, 3]. Polypeptide sequences derived from well-studied structural proteins (e.g., collagen, silk, elastin) are often used as motifs in the design and synthesis of new protein-based material, in which new functional groups may be incorporated. In this fashion, we have produced a series of silk-elastin-like proteins (SELPs) consisting of polypeptide sequences derived from silk of superior mechanical strength and elastin that is extremely durable and resilient [2, 4]. Notably, the silk-like blocks are capable of crystallizing to form virtual cross-links between elastin-mimetic sequences, which, in turn, lower the crystallinity of the silk-like blocks and thus enhance the solubility of SELPs. Consequently, SELPs may be fabricated into useful structures for biomedical applications, including drug delivery. In this study, we will characterize viscoelastic properties of SELPs, which are particularly relevant to tissue engineering applications.

scholarly journals Design and synthesis of coordination polymers with chelated units and their application in nanomaterials science

RSC Advances ◽  
2017 ◽  
Vol 7 (67) ◽  
pp. 42242-42288 ◽  
Author(s):  
Gulzhian I. Dzhardimalieva ◽  
Igor E. Uflyand
Keyword(s):  
Coordination Polymers ◽  
Design And Synthesis

The advances and problems associated with the preparation, properties and structure of coordination polymers with chelated units are presented and assessed.

Syntheses, structures and characterization of isomorphous CoII and NiII coordination polymers based on 2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole and benzene-1,4-dicarboxylate

2017 ◽  
Vol 73 (8) ◽  
pp. 645-651 ◽  
Author(s):  
Qiu-Ying Huang ◽  
Yang Zhao ◽  
Xiang-Ru Meng
Keyword(s):  
Coordination Polymers ◽  
Rational Design ◽  
Three Dimensional ◽  
Spectroscopic Properties ◽  
Polymeric Chain ◽  
Design And Synthesis ◽  
Carboxylate Groups ◽  
Metal Organic ◽  
The One ◽  
Ir Spectroscopic

Careful choice of the organic ligands is one of the most important parameters in the rational design and synthesis of coordination polymers. Aromatic polycarboxylates have been widely used in the preparation of metal–organic polymers since they can utilize various coordination modes to form diverse structures and can act as hydrogen-bond acceptors and donors in the assembly of supramolecular structures. Nitrogen-heterocyclic organic compounds have also been used extensively as ligands for the construction of polymers with interesting structures. In the polymers catena-poly[[[diaquabis{2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole-κN 3}cobalt(II)]-μ2-benzene-1,4-dicarboxylato-κ2 O 1:O 4] dihydrate], {[Co(C8H4O4)(C12H11N4)2(H2O)2]·2H2O} n , (I), and catena-poly[[[diaquabis{2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole-κN 3}nickel(II)]-μ2-benzene-1,4-dicarboxylato-κ2 O 1:O 4] dihydrate], {[Ni(C8H4O4)(C12H11N4)2(H2O)2]·2H2O} n , (II), the CoII or NiII ion lies on an inversion centre and exhibits a slightly distorted octahedral coordination geometry, coordinated by two N atoms from two imidazole rings and four O atoms from two monodentate carboxylate groups and two water molecules. The dicarboxylate ligands bridge metal ions forming a polymeric chain. The 2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole ligands coordinate to the CoII or NiII centres in monodentate modes through an imidazole N atom and are pendant on opposite sides of the main chain. The two structures are isomorphous. In the crystal, the one-dimensional chains are further connected through O—H...O, O—H...N and N—H...O hydrogen bonds, leading to a three-dimensional supramolecular architecture. In addition, the IR spectroscopic properties, PXRD patterns, thermogravimetric behaviours and fluorescence properties of both polymers have been investigated.

Design and synthesis of three new copper coordination polymers: efficient degradation of an organic dye at alkaline pH

2021 ◽  
Vol 50 (39) ◽  
pp. 13866-13876
Author(s):  
Xiaxia Liu ◽  
Liping Lu ◽  
Miaoli Zhu ◽  
Ulli Englert
Keyword(s):  
Methylene Blue ◽  
Coordination Polymers ◽  
Organic Dye ◽  
Alkaline Ph ◽  
Design And Synthesis ◽  
Copper Coordination

New Cu(ii) coordination polymers can efficiently degrade methylene blue in the presence of light and H2O2 at alkaline pH.

scholarly journals Stimuli-Responsive Aliphatic Polycarbonate Nanocarriers for Tumor-Targeted Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2890
Author(s):  
Adrian Domiński ◽  
Tomasz Konieczny ◽  
Khadar Duale ◽  
Monika Krawczyk ◽  
Gabriela Pastuch-Gawołek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Surveillance ◽  
Amphiphilic Copolymers ◽  
Stimuli Responsive ◽  
Endogenous Factors ◽  
Design And Synthesis ◽  
Oxidation Reduction ◽  
Pharmacokinetic Properties ◽  
Reactive Groups ◽  
Targeting Ability

Nanoparticles based on amphiphilic copolymers with tunable physicochemical properties can be used to encapsulate delicate pharmaceutics while at the same time improving their solubility, stability, pharmacokinetic properties, reducing immune surveillance, or achieving tumor-targeting ability. Those nanocarriers based on biodegradable aliphatic polycarbonates are a particularly promising platform for drug delivery due to flexibility in the design and synthesis of appropriate monomers and copolymers. Current studies in this field focus on the design and the synthesis of new effective carriers of hydrophobic drugs and their release in a controlled manner by exogenous or endogenous factors in tumor-specific regions. Reactive groups present in aliphatic carbonate copolymers, undergo a reaction under the action of a stimulus: e.g., acidic hydrolysis, oxidation, reduction, etc. leading to changes in the morphology of nanoparticles. This allows the release of the drug in a highly controlled manner and induces a desired therapeutic outcome without damaging healthy tissues. The presented review summarizes the current advances in chemistry and methods for designing stimuli-responsive nanocarriers based on aliphatic polycarbonates for controlled drug delivery.

Redox-Sensitive Nanoscale Coordination Polymers for Drug Delivery and Cancer Theranostics

2017 ◽  
Vol 9 (28) ◽  
pp. 23555-23563 ◽  
Author(s):  
Jiayue Zhao ◽  
Yu Yang ◽  
Xiao Han ◽  
Chao Liang ◽  
Jingjing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Cancer Theranostics ◽  
Nanoscale Coordination Polymers
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