Facile Synthesis of Multifunctional Germanium Nanoparticles as a Carrier of Quercetin to Achieve Enhanced Biological Activity

2014 ◽  
Vol 9 (8) ◽  
pp. 2272-2280 ◽  
Author(s):  
Yan-Jie Guo ◽  
Fen Yang ◽  
Lu Zhang ◽  
Jiang Pi ◽  
Ji-Ye Cai ◽  
...  
Keyword(s):  
Biological Activity ◽  
Facile Synthesis ◽  
Germanium Nanoparticles

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a

2014 ◽  
Vol 18 (03) ◽  
pp. 188-199 ◽  
Author(s):  
Áron Roxin ◽  
Thomas D. MacDonald ◽  
Gang Zheng
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Photodynamic Therapy ◽  
Natural Product ◽  
Synthesis And Characterization ◽  
Facile Synthesis ◽  
H Nmr ◽  
F Ring ◽  
C Nmr

Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is an analog of previously described natural exocyclic F-ring-containing porphyrins (1–4) and chlorins (5–10). The structure of 12 was confirmed using a combination of 1D 1 H NMR, 2D COSY 1 H NMR, Jmod 13 C NMR and HRMS analysis. The biological activity of 12 was explored, and we found that this compound does not possess strong antioxidant activity like its natural product counterparts, but is a capable photosensitizer for photodynamic therapy.

A facile synthesis and biological activity of novel tetrahydrobenzo[4′,5′]thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones

2009 ◽  
Vol 19 (23) ◽  
pp. 6713-6716 ◽  
Author(s):  
Qingyun Ren ◽  
Yong-Ju Liang ◽  
Hongwu He ◽  
Liwu Fu ◽  
Yucheng Gu
Keyword(s):  
Biological Activity ◽  
Facile Synthesis

Facile Synthesis of Germanium Nanoparticles with Size Control: Microwave versus Conventional Heating

2012 ◽  
Vol 25 (8) ◽  
pp. 1416-1422 ◽  
Author(s):  
Elayaraja Muthuswamy ◽  
Andrew S. Iskandar ◽  
Marlene M. Amador ◽  
Susan M. Kauzlarich
Keyword(s):  
Size Control ◽  
Conventional Heating ◽  
Facile Synthesis ◽  
Germanium Nanoparticles

Multicomponent facile synthesis of novel dihydroazolopyrimidinyl carbamides

2007 ◽  
Vol 61 (2) ◽  
Author(s):  
E. Gladkov ◽  
S. Sirko ◽  
B. Khanetskii ◽  
E. Lukinova ◽  
S. Desenko
Keyword(s):  
Biological Activity ◽  
Spectral Methods ◽  
Facile Synthesis ◽  
Type Reaction ◽  
Derivatives Of

AbstractNumber of novel derivatives of dihydrotriazolo-and-tetrazolopyrimidines containing carboxamide group in position 6 were obtained by multicomponent Biginelli-type reaction. The structures of all synthesized compounds were proved by NMR and MS spectral methods. The method of three-component Biginelli-type reaction is well suited for the synthesis of new promising dihydroazolopyrimidines providing a scaffold for screening of biological activity.

An expedient route to highly diversified [1,2,3]triazolo[1,5-a][1,4]benzodiazepines and their evaluation for antimicrobial, antiproliferative and in silico studies

RSC Advances ◽  
2015 ◽  
Vol 5 (81) ◽  
pp. 66260-66270 ◽  
Author(s):  
N. Sudhapriya ◽  
A. Nandakumar ◽  
Y. Arun ◽  
P. T. Perumal ◽  
C. Balachandran ◽  
...  
Keyword(s):  
Biological Activity ◽  
In Silico ◽  
Facile Synthesis ◽  
One Pot ◽  
In Silico Studies

A simple and facile synthesis of a series of diversified [1,2,3]triazolo[1,5-a][1,4]benzodiazepines has been achieved successfully via a one-pot method under milder conditions and evaluated for their biological activity.

A facile synthesis of PLGA encapsulated cerium oxide nanoparticles: release kinetics and biological activity

Nanoscale ◽  
2012 ◽  
Vol 4 (8) ◽  
pp. 2597 ◽  
Author(s):  
Virendra Singh ◽  
Sanjay Singh ◽  
Soumen Das ◽  
Amit Kumar ◽  
William T. Self ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cerium Oxide ◽  
Release Kinetics ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis
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