ChemInform Abstract: Condensed Bridgehead Nitrogen Heterocycles: Facile Synthesis and Evaluation of Biological Activity of Thiazolo(3,2-b)-s-tetrazines and cis-Dihydropyrazolo(3′,4′:4,5)thiazolo(3,2-b)-s-tetrazines.

ChemInform ◽  
2010 ◽  
Vol 27 (17) ◽  
pp. no-no
Author(s):  
J. MOHAN
Keyword(s):  
Biological Activity ◽  
Nitrogen Heterocycles ◽  
Facile Synthesis ◽  
Bridgehead Nitrogen

Synthesis and biological activity of bridgehead nitrogen heterocycles

1986 ◽  
Vol 23 (5) ◽  
pp. 1439-1442 ◽  
Author(s):  
B. N. Goswami ◽  
J. C. S. Kataky ◽  
J. N. Baruah
Keyword(s):  
Biological Activity ◽  
Nitrogen Heterocycles ◽  
Bridgehead Nitrogen

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

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