Highly Regioselective Synthesis of Polysubstituted Tetrahydroquinolines by an Iodine-Induced Tandem Cyclization Reaction from Propargylic Alcohols and Amines

2012 ◽  
Vol 7 (9) ◽  
pp. 2014-2018 ◽  
Author(s):  
Yu-Ying Ye ◽  
Lian-Biao Zhao ◽  
Shu-Chun Zhao ◽  
Fang Yang ◽  
Xue-Yuan Liu ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Regioselective Synthesis ◽  
Propargylic Alcohols ◽  
Tandem Cyclization

Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

2017 ◽  
Vol 15 (11) ◽  
pp. 2403-2410 ◽  
Author(s):  
Liang Wang ◽  
Xuehu Li ◽  
Hua Tao ◽  
Xiang Zhou ◽  
Xihong Lu ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Regioselective Synthesis ◽  
Palladium Catalyzed ◽  
Tandem Cyclization

A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds via palladium-catalyzed tandem cyclization.

Regioselective Synthesis of 2,3‐Dihydrobenzo[ f ]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

2021 ◽  
Vol 363 (4) ◽  
pp. 1038-1043
Author(s):  
Ying‐Chun He ◽  
Yan‐Mei Yan ◽  
Zhen‐Xing Ren ◽  
Yong‐Zhao Wang ◽  
Qiang Yu ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis

Synthesis of 4-styrylcoumarins via FeCl3-promoted cascade reactions of propargylamines with β-keto esters

2019 ◽  
Vol 17 (16) ◽  
pp. 4005-4013 ◽  
Author(s):  
Li-Qin Yan ◽  
Xiaoting Cai ◽  
Xinwei He ◽  
Hui Wang ◽  
Mengqing Xie ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cyclization Reaction ◽  
Quinone Methides ◽  
Keto Esters ◽  
Tandem Cyclization

A versatile and highly regioselective FeCl3-promoted tandem cyclization reaction of in situ generated alkynyl o-quinone methides (o-AQMs) with β-keto esters has been developed.

Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

Synthesis ◽  
2020 ◽  
Author(s):  
Guolin Zhang ◽  
Yongping Yu ◽  
Zijuan Wang ◽  
Wenteng Chen ◽  
Chang He
Keyword(s):  
Bond Formation ◽  
Cascade Reaction ◽  
Cyclization Reaction ◽  
One Pot ◽  
Tandem Cyclization ◽  
The One

AbstractA one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed­ cascade reaction involving C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator­ protein (TSPO) ligand.

scholarly journals Selectfluor-triggered fluorination/cyclization of o-hydroxyarylenaminones: A facile access to 3-fluoro-chromones

2020 ◽  
pp. 174751982092308
Author(s):  
Yanqin Wang ◽  
Biao Hu ◽  
Qiaohe Zhang ◽  
Siyun Zhao ◽  
Yuxuan Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
13C Nmr ◽  
Potassium Carbonate ◽  
High Resolution Mass Spectrometry ◽  
Reactive Intermediates ◽  
Cyclization Reaction ◽  
Plausible Mechanism ◽  
Tandem Cyclization ◽  
Resolution Mass

A fast and efficient Selectfluor-triggered fluorination/cyclization reaction of o-hydroxyarylenaminones has been successfully developed. The reaction successfully provides an expedient method for the synthesis of 3-fluoro-chromones promoted by potassium carbonate, which shows readily available starting materials and is easy to operate. In addition, a plausible mechanism of this tandem cyclization reaction was proposed where 4 H-chromen-4-one, 2-(dimethylamino)-3,3-difluorochroman-4-one, and 3,3-difluoro-2-hydroxychroman-4-one were not found to be the reactive intermediates. Moreover, these novel compounds have been obtained in moderate to good yields, and their structures have been confirmed by 1H NMR, 13C NMR, and high-resolution mass spectrometry.

Highly enantioselective oxidative tandem cyclization reaction: a chiral ligand and an anion cooperatively control stereoselectivity

2014 ◽  
Vol 1 (5) ◽  
pp. 473-476 ◽  
Author(s):  
Yu-Ping He ◽  
Hua Wu ◽  
Lue Xu ◽  
Yong-Liang Su ◽  
Liu-Zhu Gong
Keyword(s):  
Phosphoric Acid ◽  
Cyclization Reaction ◽  
Chiral Ligand ◽  
Highly Efficient ◽  
Straightforward Method ◽  
Chiral Phosphoric Acid ◽  
Tandem Cyclization

The unprecedented combination of a palladium(ii) complex with a chiral Bu-QUOX ligand and a chiral phosphoric acid enables the highly efficient asymmetric oxidative tandem cyclization reaction, providing a straightforward method to access chiral 6,5-bicyclic aza-heterocycles in moderate to good yields and with excellent enantioselectivities.

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