scholarly journals Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift

2020 ◽  
Author(s):  
Kevin D. Deane ◽  
V. Michael Holers
Keyword(s):  
Rheumatoid Arthritis ◽  
Paradigm Shift ◽  
Rheumatoid Arthritis Pathogenesis ◽  
Prediction And Prevention

scholarly journals Metallothionein-1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17/Treg balance

2018 ◽  
Vol 48 (9) ◽  
pp. 1550-1562 ◽  
Author(s):  
Jinxia Sun ◽  
Li Li ◽  
Lingyun Li ◽  
Liping Ding ◽  
Xiaokai Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Pathogenesis

scholarly journals T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.

1996 ◽  
Vol 184 (5) ◽  
pp. 1791-1800 ◽  
Author(s):  
E Scotet ◽  
J David-Ameline ◽  
M A Peyrat ◽  
A Moreau-Aubry ◽  
D Pinczon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Large Fraction ◽  
T Cell Response ◽  
Unknown Etiology ◽  
Rheumatoid Arthritis Pathogenesis ◽  
Chronic Rheumatoid Arthritis ◽  
Barr Virus ◽  
Epstein Barr

Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.

Sign in / Sign up

Export Citation Format

Share Document