scholarly journals Metallothionein-1 suppresses rheumatoid arthritis pathogenesis by shifting the Th17/Treg balance

2018 ◽  
Vol 48 (9) ◽  
pp. 1550-1562 ◽  
Author(s):  
Jinxia Sun ◽  
Li Li ◽  
Lingyun Li ◽  
Liping Ding ◽  
Xiaokai Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Pathogenesis

scholarly journals T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.

1996 ◽  
Vol 184 (5) ◽  
pp. 1791-1800 ◽  
Author(s):  
E Scotet ◽  
J David-Ameline ◽  
M A Peyrat ◽  
A Moreau-Aubry ◽  
D Pinczon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Large Fraction ◽  
T Cell Response ◽  
Unknown Etiology ◽  
Rheumatoid Arthritis Pathogenesis ◽  
Chronic Rheumatoid Arthritis ◽  
Barr Virus ◽  
Epstein Barr

Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.

Synovial biopsies

2020 ◽  
pp. 169-176
Author(s):  
Douglas J. Veale ◽  
Ursula Fearon
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Tissue ◽  
Disease Outcome ◽  
Response To Treatment ◽  
Significant Progress ◽  
Rheumatoid Arthritis Pathogenesis ◽  
Tissue Biopsy ◽  
Small Needle ◽  
Primary Tissue

Synovial tissue is the primary tissue inflamed in rheumatoid arthritis. Initial studies of synovial biopsies were obtained during arthroplasty or using a needle to biopsy the joint percutaneously. Recently, small needle arthroscopy or ultrasonography guided techniques have become more widely available to visualize and reliably obtain synovial biopsies. These techniques have allowed significant progress in the study of rheumatoid arthritis pathogenesis, even at the earliest stages of disease. Currently, research efforts are underway to use synovial biopsies to identify patients and to discover biomarkers that will enable clinicians to predict the course of the disease and perhaps to identify more appropriately the correct therapy for patients with rheumatoid arthritis. In this chapter, we describe the advances in synovial tissue biopsy research and how it has improved our knowledge of rheumatoid arthritis pathogenesis, informed our understanding of possible biomarkers for diagnosis and stratification, and potentially may aid in the prediction of disease outcome and response to treatment.

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