scholarly journals Altered White Matter Integrity in the Corpus Callosum in Fibromyalgia Patients Identified by Tract-Based Spatial Statistical Analysis

2014 ◽  
Vol 66 (11) ◽  
pp. 3190-3199 ◽  
Author(s):  
Dajung J. Kim ◽  
Manyoel Lim ◽  
June Sic Kim ◽  
Kyeong Min Son ◽  
Hyun Ah Kim ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
White Matter ◽  
Corpus Callosum ◽  
White Matter Integrity ◽  
Spatial Statistical Analysis

scholarly journals Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Allen A Champagne ◽  
Emile Peponoulas ◽  
Itamar Terem ◽  
Andrew Ross ◽  
Maryam Tayebi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
White Matter Tract ◽  
Exposure Group ◽  
Resonance Imaging ◽  
High Exposure

Abstract Increasing evidence for the cumulative effects of head trauma on structural integrity of the brain has emphasized the need to understand the relationship between tissue mechanic properties and injury susceptibility. Here, diffusion tensor imaging, helmet accelerometers and amplified magnetic resonance imaging were combined to gather insight about the region-specific vulnerability of the corpus callosum to microstructural changes in white-matter integrity upon exposure to sub-concussive impacts. A total of 33 male Canadian football players (meanage = 20.3 ± 1.4 years) were assessed at three time points during a football season (baseline pre-season, mid-season and post-season). The athletes were split into a LOW (N = 16) and HIGH (N = 17) exposure group based on the frequency of sub-concussive impacts sustained on a per-session basis, measured using the helmet-mounted accelerometers. Longitudinal decreases in fractional anisotropy were observed in anterior and posterior regions of the corpus callosum (average cluster size = 40.0 ± 4.4 voxels; P < 0.05, corrected) for athletes from the HIGH exposure group. These results suggest that the white-matter tract may be vulnerable to repetitive sub-concussive collisions sustained over the course of a football season. Using these findings as a basis for further investigation, a novel exploratory analysis of strain derived from sub-voxel motion of brain tissues in response to cardiac impulses was developed using amplified magnetic resonance imaging. This approach revealed specific differences in strain (and thus possibly stiffness) along the white-matter tract (P < 0.0001) suggesting a possible signature relationship between changes in white-matter integrity and tissue mechanical properties. In light of these findings, additional information about the viscoelastic behaviour of white-matter tissues may be imperative in elucidating the mechanisms responsible for region-specific differences in injury susceptibility observed, for instance, through changes in microstructural integrity following exposure to sub-concussive head impacts.

White Matter Integrity in the Corpus Callosum is Associated with Rresilience Factors in Geriatric Depression

2018 ◽  
Vol 26 (3) ◽  
pp. S117
Author(s):  
Beatrix Krause ◽  
Roza Vlasova ◽  
Amber Leaver ◽  
Kelsey T. Laird ◽  
Prabha Siddarth ◽  
...  
Keyword(s):  
White Matter ◽  
Corpus Callosum ◽  
White Matter Integrity ◽  
Geriatric Depression

Increased white matter integrity in the corpus callosum in subjects with high genetic loading for schizophrenia

2012 ◽  
Vol 37 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Sung Nyun Kim ◽  
Jun Sung Park ◽  
Joon Hwan Jang ◽  
Wi Hoon Jung ◽  
Geumsook Shim ◽  
...  
Keyword(s):  
White Matter ◽  
Corpus Callosum ◽  
White Matter Integrity ◽  
Genetic Loading
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