Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation

2013 ◽  
Vol 65 (7) ◽  
pp. 1822-1830 ◽  
Author(s):  
Kirsty L. Culley ◽  
Wang Hui ◽  
Matt J. Barter ◽  
Rose K. Davidson ◽  
Tracey E. Swingler ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Cartilage Degradation ◽  
Class I ◽  
Histone Deacetylase Inhibition

scholarly journals Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia

2017 ◽  
Vol 174 (21) ◽  
pp. 3865-3880 ◽  
Author(s):  
Marta Bombardo ◽  
Enrica Saponara ◽  
Ermanno Malagola ◽  
Rong Chen ◽  
Gitta M Seleznik ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Leukocyte Recruitment ◽  
Class I ◽  
Histone Deacetylase Inhibition ◽  
Acinar To Ductal Metaplasia

Class I and II Histone Deacetylase Inhibitor LBH589 Promotes Endocrine Differentiation in Bone Marrow Derived Human Mesenchymal Stem Cells and Suppresses Uncontrolled Proliferation

2020 ◽  
Author(s):  
Christoph Schröder ◽  
Rahul Khatri ◽  
Sebastian Friedrich Petry ◽  
Thomas Linn
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Class I ◽  
Differentiation Markers ◽  
Histone Deacetylase Inhibition ◽  
Endocrine Differentiation

AbstractMesenchymal stem cells are useful tools employed in clinical and preclinical medicine. Their beneficial potential in especially degenerative as well as autoimmune diseases is a constant focus of research. Regarding diabetes mellitus, transplantation of stem cells is seen as a possible therapeutic approach to overcome the loss of endocrine pancreatic cells. It was reported that co-transplantation of mesenchymal stem cells with pancreatic islet cells improves function and survival of the graft. However, these multipotent progenitors may be able to form tumors, especially under immunosuppressed conditions. Histone deacetylase inhibitors might offer the potential to overcome this issue. These small molecules can induce cell differentiation and control proliferation. Their potential to control lineage development of stem cells has been distinctly demonstrated in the treatment of cancer, mainly in hematopoietic neoplasias.In this study, we demonstrate that human bone marrow-derived mesenchymal stem cells exhibit low carcinogenic potential in an immunosuppressed condition in vivo. Further, the effect of histone deacetylase inhibitors LBH589, MS-275, and MGCD0103 was examined after normalizing histone deacetylase activities in culture. Interestingly, transcripts of insulin gene enhancer protein and paired-box-gene 6, two markers of pancreatic endocrine differentiation were constitutively expressed in the cell line. The broad spectrum inhibitor of class I and class II histone deacetylases LBH589 upregulated the expression of these transcription factors in a significant way, whereas addition of selective class I histone deacetylase inhibitors MS-275 and MGCD0103 did not result in significant changes in gene expression.In conclusion, we deliver evidence that a combined class I and II histone deacetylase inhibition is able to modulate the transcripts of differentiation markers of mesenchymal stem cells. The treatment holds the capability to facilitate endocrine differentiation in future approaches to replace endocrine cells by stem cell therapy.

Down-Regulation of HLA Class I Antigens in Prostate Cancer Tissues and Up-Regulation by Histone Deacetylase Inhibition

2007 ◽  
Vol 178 (2) ◽  
pp. 692-696 ◽  
Author(s):  
Hiroshi Kitamura ◽  
Toshihiko Torigoe ◽  
Hiroko Asanuma ◽  
Ichiya Honma ◽  
Noriyuki Sato ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Histone Deacetylase ◽  
Hla Class I ◽  
Class I ◽  
Down Regulation ◽  
Histone Deacetylase Inhibition ◽  
Hla Class I Antigens ◽  
Cancer Tissues

scholarly journals Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

2020 ◽  
Vol 10 (4) ◽  
pp. 615-627 ◽  
Author(s):  
Baoyuan Zhang ◽  
Junfang Lyu ◽  
Eun Ju Yang ◽  
Yifan Liu ◽  
Changjie Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Breast Cancer Cells ◽  
Class I ◽  
Histone Deacetylase Inhibition ◽  
Synthetic Lethal

scholarly journals CLASS I HISTONE DEACETYLASE INHIBITION REDUCES SUSTAINED ATRIAL FIBRILLATION AND REMODELING IN DOGS

2016 ◽  
Vol 67 (13) ◽  
pp. 671 ◽  
Author(s):  
Mitsuru Seki ◽  
Jeffery Powers ◽  
Jianhe Huang ◽  
Ryan LaCanna ◽  
Christine Varkas ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Histone Deacetylase ◽  
Class I ◽  
Histone Deacetylase Inhibition

scholarly journals Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

2018 ◽  
Vol 9 (9) ◽  
pp. 2262-2273 ◽  
Author(s):  
Wen-Ning Zhao ◽  
Balaram Ghosh ◽  
Marshall Tyler ◽  
Jasmin Lalonde ◽  
Nadine F. Joseph ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Class I ◽  
Histone Deacetylase Inhibition
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