scholarly journals Heme oxygenase 1 attenuates interleukin-1β-induced cytosolic phospholipase A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator protein 1 activation in rheumatoid arthritis synovial fibroblasts

2012 ◽  
Vol 64 (7) ◽  
pp. 2114-2125 ◽  
Author(s):  
Pei-Ling Chi ◽  
Yu-Wen Chen ◽  
Li-Der Hsiao ◽  
Yuh-Lien Chen ◽  
Chuen-Mao Yang
Keyword(s):  
Rheumatoid Arthritis ◽  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Phospholipase A2 ◽  
Heme Oxygenase ◽  
Synovial Fibroblasts ◽  
Heme Oxygenase 1 ◽  
Oxygen Species ◽  
Activator Protein 1 ◽  
Cytosolic Phospholipase

scholarly journals D5 dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1

2013 ◽  
Vol 36 (8) ◽  
pp. 684-690 ◽  
Author(s):  
Quansheng Lu ◽  
Yu Yang ◽  
Van Anthony Villar ◽  
Laureano Asico ◽  
John E Jones ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Dopamine Receptor ◽  
Heme Oxygenase ◽  
Reactive Oxygen ◽  
Heme Oxygenase 1 ◽  
Oxygen Species

Cytotoxic effects of metal protoporphyrins in glioblastoma cells: Roles of albumin, reactive oxygen species, and heme oxygenase-1

2008 ◽  
Vol 177 (2) ◽  
pp. 97-107 ◽  
Author(s):  
Jyh-Ming Chow ◽  
Guan-Cheng Huang ◽  
Hui-Yi Lin ◽  
Shing-Chuan Shen ◽  
Liang-Yo Yang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Heme Oxygenase ◽  
Reactive Oxygen ◽  
Heme Oxygenase 1 ◽  
Oxygen Species ◽  
Glioblastoma Cells ◽  
Cytotoxic Effects

scholarly journals 15-Deoxy-Δ12,14-prostaglandin J2Induces Heme Oxygenase-1 Gene Expression in a Reactive Oxygen Species-dependent Manner in Human Lymphocytes

2004 ◽  
Vol 279 (21) ◽  
pp. 21929-21937 ◽  
Author(s):  
Moisés Álvarez-Maqueda ◽  
Rajaa El Bekay ◽  
Gonzalo Alba ◽  
Javier Monteseirín ◽  
Pedro Chacón ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Heme Oxygenase ◽  
Human Lymphocytes ◽  
Reactive Oxygen ◽  
Heme Oxygenase 1 ◽  
Dependent Manner ◽  
Oxygen Species

scholarly journals Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Xian-Long Zhou ◽  
Xiao-Jun Wei ◽  
Shao-Ping Li ◽  
Rui-Ning Liu ◽  
Ming-Xia Yu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Phospholipase A2 ◽  
Cytosolic Phospholipase A2 ◽  
Ros Generation ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Diaphragm Dysfunction ◽  
Cytosolic Phospholipase ◽  
Mitochondrial Ros ◽  
Cpla2 Activation

Cytosolic phospholipase A2 (cPLA2) has been reported to be critical for infection-induced mitochondrial reactive oxygen species (ROS) production and diaphragm dysfunction (DD). In the present study, we aim to investigate whether cPLA2 was involved in ventilator-induced diaphragm dysfunction (VIDD). Our results showed that mechanical ventilation (MV) induced cPLA2 activation in the diaphragm with excessive mitochondrial ROS generation and muscle weakness. Specific inhibition of cPLA2 with CDIBA resulted in decreased mitochondrial ROS levels and improved diaphragm forces. In addition, mitochondria-targeted antioxidant MitoTEMPO attenuated ventilator-induced mitochondrial oxidative stress and downregulated cPLA2 activation in vivo. Both CDIBA and MitoTEMPO were able to attenuate protein degradation, muscle atrophy, and weakness following prolonged MV. Furthermore, laser Doppler imaging showed that MV decreased diaphragm tissue perfusion and induced subsequent hypoxia. An in vitro study also demonstrated a positive association between cPLA2 activation and mitochondrial ROS generation in C2C12 cells cultured under hypoxic condition. Collectively, our study showed that cPLA2 activation positively interacts with mitochondrial ROS generation in the development of VIDD, and ventilator-induced diaphragm hypoxia serves as a possible contributor to this positive feedback loop.

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