The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy

2009 ◽  
Vol 60 (1) ◽  
pp. 290-298 ◽  
Author(s):  
Nathalie W. D. Jansen ◽  
Goris Roosendaal ◽  
Björn Lundin ◽  
Lily Heijnen ◽  
Evelien Mauser-Bunschoten ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Cartilage Damage ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Hemophilic Arthropathy

Theory of the Short Time Mechanical Relaxation in Articular Cartilage

2011 ◽  
Vol 133 (10) ◽  
Author(s):  
J. W. Ruberti ◽  
J. B. Sokoloff
Keyword(s):  
Hyaluronic Acid ◽  
Articular Cartilage ◽  
Chondroitin Sulfate ◽  
Relaxation Times ◽  
Type Ii Collagen ◽  
Mechanical Relaxation ◽  
Side Chains ◽  
Type Ii ◽  
Interface Area ◽  
Short Time

Articular cartilage is comprised of macromolecules, proteoglycans, with (charged) chondroitin sulfate side-chains attached to them. The proteoglycans are attached to longer hyaluronic acid chains, trapped within a network of type II collagen fibrils. As a consequence of their relatively long persistence lengths, the number of persistence lengths along the chondroitin sulfate and proteoglycan chains is relatively small, and consequently, the retraction times for these side chains are also quite short. We argue that, as a consequence of this, they will not significantly inhibit the reptation of the hyaluronic acid chains. Scaling arguments applied to this model allow us to show that the shortest of the mechanical relaxation times of cartilage, that have been determined by Fyhrie and Barone to be due to reptation of the hyaluronic acid polymers, should have a dependence on the load, i.e., force per unit interface area P, carried by the cartilage, proportional to P3/2.

Characterisation of freeze-dried type II collagen and chondroitin sulfate scaffolds

2013 ◽  
Vol 24 (5) ◽  
pp. 1153-1165 ◽  
Author(s):  
M. Tamaddon ◽  
R. S. Walton ◽  
D. D. Brand ◽  
J. T. Czernuszka
Keyword(s):  
Chondroitin Sulfate ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Freeze Dried

Serum Cartilage Oligometric Matrix Protein and Pettersson Scoring System As an Index for Hemophilic Arthropathy

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2855-2855
Author(s):  
Hoda MA Hassab ◽  
Wessam M EL-Gendy ◽  
Khaled I M El-Noueam ◽  
Hayam M Abdel Ghany ◽  
Myssoon M Elwan
Keyword(s):  
Serum Level ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Joint Space Narrowing ◽  
Joint Damage ◽  
Joint Space ◽  
Functional Independence ◽  
Control Group ◽  
Hemophilic Arthropathy ◽  
Group I

Abstract The pathogenesis of hemophilic arthropathy is multifactorial, with changes occurring in the synovium, bone, cartilage, and blood vessels. Recurrent joint bleeding causes synovial proliferation and inflammation (hemophilic synovitis) that contributes to end stage degeneration (hemophilic arthropathy); with pain and limitation of motion that severely affects patients’ quality of life. The aim of the present study was to evaluate the degree of joint damage in boys with hemophilia using plain x-ray, and to measure serum level of human cartilage oligomeric matrix protein, to determine its relation to the degree of joint damage. The study was carried out on thirty boys with hemophilic arthropathy (group I) and ten healthy boys were included as control (group II). All hemophilic patients were scored for Functional independence score (FISH score) in hemophilia and radiological changes (Pettersson’s score) using conventional frontal and lateral radiographs of the most affected joint. Factor activity level was measured for all hemophilic patients while serum cartilage oligomeric matrix protein (COMP) was measured for hemophilic patients and control group. Among the thirty hemophilic patients, 26 (86.7%) patients were hemophilia A and 4 (13.3%) patients were hemophilia B All patients were receiving on demand replacement therapy using plasma derived Factor concentrate or fresh frozen plasma (FFP) according to availability. Fifteen patients (50%) had severe hemophilia, 7 (23.3%) had moderate and 8(26.72%) had mild hemophilia. A higher serum level of COMP with a mean of 757± 211.30 in the severe hemophiliacs, and a mean of 403.57 ± 86.49 and 211.25 ± 74.26 in the moderate and mild hemophiliacs respectively the difference was statistically significant (p < 0.001). Serum level of COMP in group I was significantly higher than in group II (p=0.004) with significant negative correlation with FISH score (r=-0.435 p=0.016). COMP correlated positively with joint space narrowing of the Pettersson score (r=0.421 p<0.001) and with total Pettersson score (r=0.421 p=0.020). The number of joints affected (during life) of hemophilic patients ranged between 1-12 with a mean of 5.50 ± 2.46 Joints. A significant positive correlation between serum level of COMP and number of joints affected (r = 0.487, p = 0.006). Joint space narrowing is the most important indicator of cartilage loss. Serum COMP level is indicative of the amount of joint damage in patients with hemophilic arthropathy. The combined scoring of functional independence and Pettersson in addition with serum levels of COMP give a good overview of the degree of hemophilic arthropathy Disclosures No relevant conflicts of interest to declare.

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