Noninvasive imaging of macrophages in rheumatoid synovitis using11C-(R)-PK11195 and positron emission tomography

2008 ◽  
Vol 58 (11) ◽  
pp. 3350-3355 ◽  
Author(s):  
Conny J. van der Laken ◽  
Ernst H. Elzinga ◽  
Mark A. Kropholler ◽  
Carla F. M. Molthoff ◽  
Joost W. van der Heijden ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Noninvasive Imaging ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Noninvasive Pulmonary [18F]-2-Fluoro-Deoxy-d-Glucose Positron Emission Tomography Correlates with Bactericidal Activity of Tuberculosis Drug Treatment

2009 ◽  
Vol 53 (11) ◽  
pp. 4879-4884 ◽  
Author(s):  
Stephanie L. Davis ◽  
Eric L. Nuermberger ◽  
Peter K. Um ◽  
Camille Vidal ◽  
Bruno Jedynak ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Bactericidal Activity ◽  
Fdg Pet ◽  
Point Of Care ◽  
Noninvasive Imaging ◽  
Emission Tomography ◽  
Response To Treatment ◽  
Tb Treatment ◽  
Positron Emission ◽  
Drug Regimens

ABSTRACT Tools for monitoring response to tuberculosis (TB) treatment are time-consuming and resource intensive. Noninvasive biomarkers have the potential to accelerate TB drug development, but to date, little progress has been made in utilizing imaging technologies. Therefore, in this study, we used noninvasive imaging to monitor response to TB treatment. BALB/c and C3HeB/FeJ mice were aerosol infected with Mycobacterium tuberculosis and administered bactericidal (standard and highly active) or bacteriostatic TB drug regimens. Serial pulmonary [18F]-2-fluoro-deoxy-d-glucose (FDG) positron emission tomography (PET) was compared with standard microbiologic methods to monitor the response to treatment. [18F]FDG-PET correctly identified the bactericidal activity of the drug regimens. Imaging required fewer animals; was available in real time, as opposed to having CFU counts 4 weeks later; and could also detect TB relapse in a time frame similar to that of the standard method. Lesion-specific [18F]FDG-PET activity also broadly correlated with TB treatment in C3HeB/FeJ mice that develop caseating lesions. These studies demonstrate the application of noninvasive imaging to monitor TB treatment response. By reducing animal numbers, these biomarkers will allow cost-effective studies of more expensive animal models of TB. Validated markers may also be useful as “point-of-care” methods to monitor TB treatment in humans.

scholarly journals Noninvasive imaging of islet grafts using positron-emission tomography

2006 ◽  
Vol 103 (30) ◽  
pp. 11294-11299 ◽  
Author(s):  
Y. Lu ◽  
H. Dang ◽  
B. Middleton ◽  
Z. Zhang ◽  
L. Washburn ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Noninvasive Imaging ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Noninvasive Imaging of Transgene Expression by Use of Positron Emission Tomography in a Pig Model of Myocardial Gene Transfer

Circulation ◽  
2003 ◽  
Vol 108 (17) ◽  
pp. 2127-2133 ◽  
Author(s):  
Frank M. Bengel ◽  
Martina Anton ◽  
Thomas Richter ◽  
Marcus V. Simoes ◽  
Roland Haubner ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Gene Transfer ◽  
Transgene Expression ◽  
Noninvasive Imaging ◽  
Pig Model ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Direct, Quantitative, and Noninvasive Imaging of the Transport of Active Agents Through Intact Brain with Positron Emission Tomography

2013 ◽  
Vol 15 (5) ◽  
pp. 596-605 ◽  
Author(s):  
Rachael W. Sirianni ◽  
Ming-Qiang Zheng ◽  
W. Mark Saltzman ◽  
Yiyun Huang ◽  
Richard E. Carson
Keyword(s):  
Positron Emission Tomography ◽  
Noninvasive Imaging ◽  
Emission Tomography ◽  
Positron Emission ◽  
Intact Brain
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