Association of health-related quality of life with dual use of prescription and over-the-counter nonsteroidal antiinflammatory drugs

2008 ◽  
Vol 59 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Stacey H. Kovac ◽  
Kenneth G. Saag ◽  
Jeffrey R. Curtis ◽  
Jeroan Allison
Keyword(s):  
Quality Of Life ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Health Related Quality ◽  
Dual Use ◽  
Antiinflammatory Drugs ◽  
Over The Counter ◽  
Related Quality ◽  
Health Related

C-Reactive Protein, Antiinflammatory Drugs, and Quality of Life in Diabetes

2003 ◽  
Vol 37 (11) ◽  
pp. 1593-1597 ◽  
Author(s):  
Doyle M Cummings ◽  
Dana E King ◽  
Arch G Mainous
Keyword(s):  
Quality Of Life ◽  
Inverse Relationship ◽  
Medication Use ◽  
Health Related Quality ◽  
C Reactive Protein ◽  
Antiinflammatory Drugs ◽  
Reactive Protein ◽  
Related Quality ◽  
Health Related

BACKGROUND: C-reactive protein (CRP) is an important biological marker of inflammation that has been linked to cardiovascular disease. The extent to which the inflammatory processes associated with elevated CRP concentrations impair physical functioning and quality of life, and whether this is modulated by hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) and aspirin, which have been shown to lower CRP concentrations, is unclear. OBJECTIVE: To determine whether an association exists between CRP concentrations and health-related quality of life among patients with diabetes, and to determine whether the association is affected by use of statins and nonsteroidal antiinflammatory drugs (NSAIDs). METHODS: A trained interviewer collected self-reported information regarding demographics, health-related quality of life (SF-12), and medication use, and a nurse collected a blood sample from 86 adult subjects with type 2 diabetes mellitus who were part of a larger population-based survey. The serum was analyzed for CRP using a highly sensitive assay. RESULTS: In simple bivariate analysis, there was a significant inverse relationship between CRP and the physical health component score of health-related quality of life (Spearman correlation coefficient [r] = −0.26; p = 0.025). For subjects on statins (r = −0.44; p = 0.02; n = 27), this relationship persisted, while for patients on NSAIDs or aspirin (r = −0.21; p = 0.17; n = 44), no relationship was observed. Similar findings were observed with self-rated health alone as an outcome variable. However, stepwise linear regression revealed no consistent relationship between CRP and health-related quality of life (i.e., standardized SF-12 physical component score) when demographic variables, disease duration, glucose control, serum creatinine, smoking, and medication use were controlled for. CONCLUSIONS: In multivariate regression modeling, the initial inverse relationship between CRP and health-related quality of life was lost, suggesting that other covariates are responsible for this association. While statins and NSAIDs may impact CRP or health-related quality of life independently, they do not appear to modulate a relationship between these factors.

Impact of Over-the-Counter Medication Misuse and Adverse Drug Events on HIV Patients' Health-Related Quality of Life

2008 ◽  
Vol 24 (6) ◽  
pp. 323-329 ◽  
Author(s):  
Sujit S Sansgiry ◽  
Elizabeth Ajuoga ◽  
Caroline Ngo ◽  
Rosa F Yeh
Keyword(s):  
Quality Of Life ◽  
Adverse Drug Events ◽  
Short Form ◽  
Health Related Quality ◽  
Over The Counter ◽  
Medication Misuse ◽  
Validated Questionnaire ◽  
Related Quality ◽  
Health Related

Background: Over-the-counter (OTC) medication use has increased among HIV-infected patients. Inappropriate use of OTC drugs may increase the risk of potential adverse drug events (ADEs), thus decreasing health-related quality of life (HRQL). Objective: To examine the effect of OTC medication misuse and associated ADEs on HRQL of HIV-infected patients. Methods: A cross-sectional field study with HIV-infected patients from an HIV clinic in Houston, Texas, was conducted from April 1, 2005, to June 30, 2005. A validated questionnaire (including questions on OTC medications used; ADEs experienced; and HRQL, Short Form-12, version 2 scale) was administered using self-administered and personal interview techniques. Cronbach's α was estimated to evaluate internal consistency for HRQL scores and χ2 and t-test analyses were performed to evaluate the effect of OTC misuse on ADEs and on HRQL. Results: Of the 215 respondents, 80 (37.2%) misused OTC medications. Thirty-six participants (16.7%) experienced ADEs due to OTC use or misuse. ADE incidence was significantly higher in patients misusing OTCs. Significantly lower HRQL scores for the physical component summary score domains were observed in patients reporting ADEs versus those who did not. Conclusions: HIV-infected patients had lower HRQL scores when they experienced an OTC-associated ADE. Patients misusing OTC medications had a higher incidence of associated ADEs. Interventions by healthcare providers and patients aimed at reducing misuse and ADEs due to OTC medications would improve care and the quality of life for HIV-infected patients.

465: Impact of Post-Prostatectomy Urethral Strictures on Urinary and Sexual Health Related Quality of Life

2006 ◽  
Vol 175 (4S) ◽  
pp. 150-151
Author(s):  
Jeffrey S. Montgomery ◽  
Bishoy A. Gayed ◽  
Brent K. Hollenbeck ◽  
Stephanie Daignault ◽  
Martin G. Sanda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Health ◽  
Health Related Quality ◽  
Urethral Strictures ◽  
Related Quality ◽  
Health Related
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