scholarly journals High-sensitivity C-reactive protein in chronic low back pain with vertebral end-plate modic signal changes

2007 ◽  
Vol 57 (7) ◽  
pp. 1311-1315 ◽  
Author(s):  
François Rannou ◽  
Walid Ouanes ◽  
Isabelle Boutron ◽  
Bianca Lovisi ◽  
Fouad Fayad ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
High Sensitivity ◽  
Low Back ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
End Plate ◽  
Signal Changes

scholarly journals The association between insomnia, c-reactive protein, and chronic low back pain: cross-sectional analysis of the HUNT study, Norway

2019 ◽  
Vol 19 (4) ◽  
pp. 765-777 ◽  
Author(s):  
Kevin Kwan Ngai Ho ◽  
Milena Simic ◽  
Milada Cvancarova Småstuen ◽  
Marina de Barros Pinheiro ◽  
Paulo Herrique Ferreira ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Total Sample ◽  
Low Back ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Sectional Analysis ◽  
Very High

Abstract Background and aims Chronic low back pain (chronic LBP) is the number one cause for years lived with disability among 301 diseases and injuries analyzed by The Global Burden of Disease study 2013. Insomnia is highly prevalent among people with chronic LBP. To explain the sleep-pain relationship, theoretical models propose that insomnia symptoms may be associated with increased basal inflammation, operationalized as c-reactive protein (CRP) and lead to further pain and disrupted sleep. We aimed to determine the associations between insomnia, chronic LBP, and inflammation (operationalized as CRP), whilst controlling for age, body mass index, smoking, physical activity, depression, anxiety and osteoarthritis. Methods A cross-sectional analysis of the third Nord-Trøndelag Health Study (2006–2008), a rural population survey of 50,666 participants in Norway aged 20–96 years. Insomnia (dichotomous) was defined according to the Diagnostic and Statistical Manual of Mental Disorders 5th Edition, and chronic LBP (dichotomous) as low back pain or stiffness lasting at least 3 months. Data for CRP were obtained from non-fasting serum samples and assessed via latex immunoassay methodology. We excluded participants with the following self-reported chronic somatic diseases: chronic heart failure, chronic obstructive pulmonary disease, rheumatoid arthritis, fibromyalgia or ankylosing spondylosis. Possible associations between presence of insomnia and presence of chronic LBP (dependent), and the level of CRP and presence of chronic LBP (dependent), were assessed using logistic regression models. The possible association between insomnia and CRP (dependent) was assessed using linear regression. Multivariable analyses were conducted adjusting for confounders stated in our aim that achieved p ≤ 0.2 in univariate regressions. We performed stratified analyses for participants with “Normal” (<3 mg/L) “Elevated” (3–10 mg/L) and “Very High” (>10 mg/L) levels of CRP. Results In our total included sample (n = 30,669, median age 52.6, 54% female), 6.1% had insomnia (n = 1,871), 21.4% had chronic LBP (n = 6,559), and 2.4% had both (n = 719). Twenty four thousand two hundred eighty-eight (79%) participants had “Normal” CRP, 5,275 (17%) had “Elevated” CRP, and 1,136 (4%) had “Very High” CRP. For participants with “Normal” levels of CRP, insomnia was associated with higher levels of CRP (adjusted B = 0.04, 95%CI [0.00–0.08], p = 0.046), but not for people with “Elevated” or “Very High” levels of CRP. There was an association between CRP and presence of chronic LBP in the total sample (adjusted OR = 1.01, [1.00–1.01], p = 0.013) and for people with “Normal” CRP (1.05, [1.00–1.10, p = 0.034]. Insomnia was associated with the presence of chronic LBP in the total sample (adjusted OR = 1.99, 95%CI [1.79–2.21], <0.001) and for people with “Normal”, “Elevated” and “Very High”. Conclusions Individuals with insomnia have twice the odds of reporting chronic LBP. Insomnia, CRP and chronic LBP appear to be linked but the role of CRP appears to be limited. Longitudinal studies may help further explore the causal inference between insomnia chronic LBP, and inflammation. Implications Given the strong relationship between insomnia and chronic LBP, screening and management of comorbid insomnia and chronic LBP should be considered in clinical practice. Further longitudinal studies are required to explore whether the presence of insomnia and increased inflammation affects the development of chronic LBP.

Multi-trajectory analysis of C-reactive protein and low back pain from adolescence to early adulthood

2021 ◽  
Author(s):  
Amber M Beynon ◽  
Jeffrey J Hebert ◽  
Darren J Beales ◽  
Angela Jacques ◽  
Bruce F Walker
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Trajectory Analysis ◽  
Early Adulthood ◽  
Low Back ◽  
C Reactive Protein ◽  
Reactive Protein

Relations of C-Reactive Protein and Obesity to the Prevalence and the Odds of Reporting Low Back Pain

2013 ◽  
Vol 94 (4) ◽  
pp. 745-752 ◽  
Author(s):  
Matthew S. Briggs ◽  
Deborah L. Givens ◽  
Laura C. Schmitt ◽  
Christopher A. Taylor
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
C Reactive Protein ◽  
Reactive Protein
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