scholarly journals Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti–citrullinated protein antibodies in rheumatoid arthritis

2006 ◽  
Vol 54 (3) ◽  
pp. 733-741 ◽  
Author(s):  
Federico Pratesi ◽  
Cristina Tommasi ◽  
Consuelo Anzilotti ◽  
Daniele Chimenti ◽  
Paola Migliorini
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr ◽  
Citrullinated Protein

scholarly journals Isotypes of Epstein-Barr Virus Antibodies in Rheumatoid Arthritis: Association with Rheumatoid Factors and Citrulline-Dependent Antibodies

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Marie Wulff Westergaard ◽  
Anette Holck Draborg ◽  
Lone Troelsen ◽  
Søren Jacobsen ◽  
Gunnar Houen
Keyword(s):  
Rheumatoid Arthritis ◽  
Lupus Erythematosus ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Rheumatoid Factors ◽  
Humoral Immune ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Citrullinated Protein

In order to study the humoral immune response against Epstein-Barr virus (EBV) in patients with rheumatoid arthritis (RA) and to compare it with the two major autoantibody types in RA, plasma samples from 77 RA patients, 28 patients with systemic lupus erythematosus (SLE), and 28 healthy controls (HCs) were investigated by enzyme-linked immunosorbent assays (ELISA). Increased percentages of positives and concentrations of IgG/IgA/IgM antibodies against the latent EBV nuclear antigen-1 (EBNA-1) were observed in RA patients compared to SLE patients and HCs. Increased concentrations and percentages of positives of IgG/IgA/IgM against the early lytic EBV antigen diffuse (EAD) were also found in RA patients compared to HCs but were highest in SLE patients. Furthermore, associations between the elevated EBNA-1 IgA and EBNA-1 IgM levels and the presence of IgM and IgA rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs, IgG) and between elevated IgA concentrations against EAD and the presence of RFs and ACPAs in RA patients were found. Thus, RA patients had elevated antibodies of all isotypes characteristic of latent EBV infection (whereas SLE patients had elevated antibodies characteristic of lytic EBV infection). Notably, for IgM and IgA (but not IgG), these were associated with the presence of characteristic RA autoantibodies.

scholarly journals Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial　tissues of rheumatoid arthritis

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208957 ◽  
Author(s):  
Shotaro Masuoka ◽  
Natsuko Kusunoki ◽  
Ryo Takamatsu ◽  
Hiroshi Takahashi ◽  
Kazuaki Tsuchiya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Synovial Tissues ◽  
Barr Virus Infection ◽  
Epstein Barr Nuclear Antigen

Anti-Epstein-Barr Virus-Nuclear Antigen-1,-2A and-2B Antibodies in Rheumatoid Arthritis Patients and Their Relatives

Autoimmunity ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 225-231 ◽  
Author(s):  
Pierre Youinou ◽  
Marlyse Buisson ◽  
Jean-Marie Berthelot ◽  
Christophe Jamin ◽  
Paul Le Goff ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Rheumatoid Arthritis Nuclear Antigen and Epstein-Barr Virus

1984 ◽  
Vol 27 (4) ◽  
pp. 476-477 ◽  
Author(s):  
Patrick J. W. Venables ◽  
Paul R. Smith ◽  
Ravinder N. Maini
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals EBNA1 IgM-Based Discrimination Between Rheumatoid Arthritis Patients, Systemic Lupus Erythematosus Patients and Healthy Controls

Antibodies ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 35 ◽  
Author(s):  
Nicole Hartwig Trier ◽  
Anette Holck Draborg ◽  
Louise Sternbæk ◽  
Lone Troelsen ◽  
Janni Lisander Larsen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Epstein Barr Virus ◽  
Connective Tissue Diseases ◽  
Nuclear Antigen ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Barr Virus ◽  
Epstein Barr

Epstein–Barr Virus (EBV) has been associated with development of rheumatic connective tissue diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in genetically susceptible individuals. Diagnosis of RA and SLE relies on clinical criteria in combination with the presence of characteristic autoantibodies. In addition, antibodies to several EBV antigens have been shown to be elevated in patients with these diseases compared to healthy controls (HC). Here, we elaborated improved enzyme-linked immunosorbent assays for antibodies (IgM, IgA, IgG) to the EBV proteins Epstein-Barr Virus nuclear antigen (EBNA)1 and early antigen diffuse (EAD) in order to determine their potential diagnostic role. We showed that especially EBNA1 IgM distinguished RA from SLE and HCs and also distinguished SLE from HCs. EBNA1 IgA was almost as effective in differentiating RA from SLE and HC, while EAD IgG and IgA were able to discern SLE patients from RA patients and HCs. Collectively, these findings illustrate the potential diagnostic use of antibodies to EBV proteins to diagnose RA and to differentiate SLE from RA.

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