scholarly journals Correlation between the presence of antibodies to the Epstein-barr virus nuclear antigen type 2 and antibodies to the rheumatoid arthritis nuclear antigen in patients with rheumatoid arthritis

1986 ◽  
Vol 29 (8) ◽  
pp. 964-970 ◽  
Author(s):  
Thomas B. Sculley ◽  
John H. Pope ◽  
Ron A. Hazelton
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Type 2 Cytokines Predominate in the Human CD4+T-Lymphocyte Response to Epstein-Barr Virus Nuclear Antigen 1

2000 ◽  
Vol 74 (15) ◽  
pp. 6748-6759 ◽  
Author(s):  
Patricia Steigerwald-Mullen ◽  
Michael G. Kurilla ◽  
Thomas J. Braciale
Keyword(s):  
T Lymphocytes ◽  
Epstein Barr Virus ◽  
Adult Population ◽  
Human Herpesvirus ◽  
Nuclear Antigen ◽  
Consistent Difference ◽  
Characteristic Type ◽  
Barr Virus ◽  
Epstein Barr

ABSTRACT Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that persistently infects 85% of the adult population worldwide. In this report, we examine the proliferative response and cytokine secretion profile of CD4+ T lymphocytes from a panel of unrelated EBV-positive donors against two EBV latent antigens, EBNA1 and EBNA3C. Substantial proliferative responses by CD4+ lymphocytes were demonstrated to both antigens in multiple, randomly selected donors. Surprisingly, we observed a striking and consistent difference in cytokine response to EBNA1 and EBNA3C. EBNA1-specific CD4+ T lymphocytes from multiple unrelated donors preferentially produced type 2-like cytokines in response to antigenic stimulation, while the response to EBNA3C was a characteristic type 1 response. The implications of these findings for EBV persistence and the development of EBV-associated malignancies are discussed.

scholarly journals HLA-A11-Restricted Epitope Polymorphism among Epstein-Barr Virus Strains in the Highly HLA-A11-Positive Chinese Population: Incidence and Immunogenicity of Variant Epitope Sequences

2003 ◽  
Vol 77 (21) ◽  
pp. 11507-11516 ◽  
Author(s):  
R. S. Midgley ◽  
A. I. Bell ◽  
Q. Y. Yao ◽  
D. Croom-Carter ◽  
A. D. Hislop ◽  
...  
Keyword(s):  
Chinese Population ◽  
Epstein Barr Virus ◽  
Cytotoxic T Lymphocyte ◽  
Nuclear Antigen ◽  
Sequence Variants ◽  
Barr Virus ◽  
Epstein Barr

ABSTRACT An individual's CD8+-cytotoxic-T-lymphocyte (CTL) response to Epstein-Barr virus (EBV) latent cycle antigens focuses on a small number of immunodominant epitopes often presented by just one of the available HLA class I alleles; for example, HLA-A11-positive Caucasians frequently respond to two immunodominant HLA A11 epitopes, IVTDFSVIK (IVT) and AVFDRKSDAK (AVF), within the nuclear antigen EBNA3B. Here, we reexamine the spectrum of EBV strains present in the highly HLA-A11-positive Chinese population for sequence changes in these epitopes relative to the Caucasian type 1 prototype strain B95.8. The IVT epitope was altered in 61 of 64 Chinese type 1 viruses, with four different sequence variants being observed, and the AVF epitope was altered in 46 cases with six different sequence variants; by contrast, all 10 Chinese type 2 viruses retained the prototype 2 epitope sequences. All but one of the type 1 epitope variants were poorly recognized by IVT- or AVF-specific CTLs in pulse-chase assays of peptide-mediated target cell lysis. More importantly, we screened HLA-A11-positive Chinese donors carrying viruses with known epitope mutations for evidence of epitope-specific CTL memory by enzyme-linked immunospot assays: none of the type 1 variants tested, nor the type 2 prototype, appeared to be immunogenic in vivo. The data remain consistent with the possibility that, during virus-host coevolution, pressure from the host CTL-mediated immune response has given A11 epitope-loss viruses a selective advantage.

scholarly journals Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial　tissues of rheumatoid arthritis

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208957 ◽  
Author(s):  
Shotaro Masuoka ◽  
Natsuko Kusunoki ◽  
Ryo Takamatsu ◽  
Hiroshi Takahashi ◽  
Kazuaki Tsuchiya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Synovial Tissues ◽  
Barr Virus Infection ◽  
Epstein Barr Nuclear Antigen

Anti-Epstein-Barr Virus-Nuclear Antigen-1,-2A and-2B Antibodies in Rheumatoid Arthritis Patients and Their Relatives

Autoimmunity ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 225-231 ◽  
Author(s):  
Pierre Youinou ◽  
Marlyse Buisson ◽  
Jean-Marie Berthelot ◽  
Christophe Jamin ◽  
Paul Le Goff ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Isotypes of Epstein-Barr Virus Antibodies in Rheumatoid Arthritis: Association with Rheumatoid Factors and Citrulline-Dependent Antibodies

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Marie Wulff Westergaard ◽  
Anette Holck Draborg ◽  
Lone Troelsen ◽  
Søren Jacobsen ◽  
Gunnar Houen
Keyword(s):  
Rheumatoid Arthritis ◽  
Lupus Erythematosus ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Rheumatoid Factors ◽  
Humoral Immune ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Citrullinated Protein

In order to study the humoral immune response against Epstein-Barr virus (EBV) in patients with rheumatoid arthritis (RA) and to compare it with the two major autoantibody types in RA, plasma samples from 77 RA patients, 28 patients with systemic lupus erythematosus (SLE), and 28 healthy controls (HCs) were investigated by enzyme-linked immunosorbent assays (ELISA). Increased percentages of positives and concentrations of IgG/IgA/IgM antibodies against the latent EBV nuclear antigen-1 (EBNA-1) were observed in RA patients compared to SLE patients and HCs. Increased concentrations and percentages of positives of IgG/IgA/IgM against the early lytic EBV antigen diffuse (EAD) were also found in RA patients compared to HCs but were highest in SLE patients. Furthermore, associations between the elevated EBNA-1 IgA and EBNA-1 IgM levels and the presence of IgM and IgA rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs, IgG) and between elevated IgA concentrations against EAD and the presence of RFs and ACPAs in RA patients were found. Thus, RA patients had elevated antibodies of all isotypes characteristic of latent EBV infection (whereas SLE patients had elevated antibodies characteristic of lytic EBV infection). Notably, for IgM and IgA (but not IgG), these were associated with the presence of characteristic RA autoantibodies.

scholarly journals Rheumatoid Arthritis Nuclear Antigen and Epstein-Barr Virus

1984 ◽  
Vol 27 (4) ◽  
pp. 476-477 ◽  
Author(s):  
Patrick J. W. Venables ◽  
Paul R. Smith ◽  
Ravinder N. Maini
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr
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