scholarly journals FDA ARTHRITIS ADVISORY COMMITTEE MEETING: GUIDELINES FOR APPROVING NONSTEROIDAL ANTIINFLAMMATORY DRUGS FOR OVER-THE-COUNTER USE

1990 ◽  
Vol 33 (7) ◽  
pp. 1056-1058 ◽  
Author(s):  
Harold E. Paulus
Keyword(s):  
Advisory Committee ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Committee Meeting ◽  
Antiinflammatory Drugs ◽  
Over The Counter

Nonopioid Analgesics

2015 ◽  
Author(s):  
Sean Rhyee ◽  
Katherine Boyle
Keyword(s):  
The United States ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs ◽  
Over The Counter ◽  
King's College ◽  
Definitive Therapy ◽  
King’S College Criteria ◽  
Toxic Ingestion ◽  
Nonopioid Analgesics ◽  
Pie Chart

Acetaminophen is the most common toxic ingestion in the United States, causing 400 deaths per year. Poisoning occurs both intentionally and unintentionally, with suicidal intent, overuse for treatment of pain, and ingestion of multiple medications containing acetaminophen all contributing. Aspirin poisoning remains a concern even though its popularity as an analgesic and antipyretic has decreased over time. Among nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs), ibuprofen and naproxen are the most commonly encountered in overdose, likely due to their easy availability as over-the-counter medications. This review covers the principles of toxicity, immediate stabilization, diagnosis and definitive therapy, and disposition and outcomes related to acetaminophen, aspirin, and ibuprofen and other NSAIDs. Tables describe N-acetylcysteine dosing, King’s College criteria for acetaminophen-induced liver failure, and indications for hemodialysis in aspirin poisoning. Figures include a pie chart showing acetaminophen metabolization, the Rumack-Matthew nomogram, and a graph showing frequency of hepatotoxicity in patients receiving N-acetylcysteine. This review contains 3 highly rendered figures, 3 tables, and 97 references.

Suppository Preparation: Density Factor Determination for Some Over-the-Counter Analgesic Products

2009 ◽  
Vol 25 (5) ◽  
pp. 303-308
Author(s):  
Antoine Al-Achi ◽  
Sapana Patel ◽  
Krishna Cherukuri ◽  
Dinal Gandhi
Keyword(s):  
North Carolina ◽  
Practical Method ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Antiinflammatory Drugs ◽  
Over The Counter ◽  
Solid Dosage ◽  
Porcelain Mortar ◽  
Density Factor

Background: The formulation of analgesic suppositories by the compounding pharmacist may offer an alternative to patients who cannot take medications orally. Objective: To determine the density factor (DF) for 9 nonprescription nonsteroidal antiinflammatory drugs, aspirin, and acetaminophen for use in compounding suppositories. Methods: Nine nonprescription analgesic products were purchased from local stores in North Carolina. All products were solid dosage forms (ie, tablets, caplets, or geltabs). The solid units were pulverized with a porcelain mortar and pestle and then incorporated into a cocoa butter base for formulating the suppository. The DF estimation was evaluated according to the Paddock method. Results: The highest DF value (mean ± SD) among the products tested was for St. Joseph Aspirin (1.45 ± 0.78); the lowest value was for Motrin IB (ibuprofen) (1.06 ± 0.23). Overall, 11.1% (40/360) of all compounded suppositories had some sort of defect. The most often encountered defect was chipping (3.6%; 13/360); the least encountered was sticking to molds (0.83%; 3/360). Conclusions: A practical method for preparing compounded suppositories provides a viable alternative for patients who require analgesic medications but cannot take them orally.

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