scholarly journals Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

2002 ◽  
Vol 46 (8) ◽  
pp. 2087-2094 ◽  
Author(s):  
William Wu ◽  
R. Clark Billinghurst ◽  
Isabelle Pidoux ◽  
John Antoniou ◽  
David Zukor ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Matrix Metalloproteinase ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Matrix Metalloproteinase 13 ◽  
Matrix Metalloproteinase 1

scholarly journals Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

2021 ◽  
Vol 22 (4) ◽  
pp. 1742
Author(s):  
Qichan Hu ◽  
Melanie Ecker
Keyword(s):  
Articular Cartilage ◽  
Matrix Metalloproteinase ◽  
Chronic Inflammation ◽  
Molecular Mechanisms ◽  
Type Ii Collagen ◽  
Cartilage Degradation ◽  
Type Ii ◽  
Inhibitor Development ◽  
Matrix Metalloproteinase 13 ◽  
Promising Target

Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA. However, the detailed molecular mechanisms of OA initiation and progression remain elusive, and, currently, there are no interventions available to restore degraded cartilage. This review fully illustrates the involvement of MMP-13 in the initiation and progression of OA through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.

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