scholarly journals Design, synthesis, and antiproliferative effect of 2,9‐bis[4‐(pyridinylalkylaminomethyl)phenyl]‐1,10‐phenanthroline derivatives on human leukemic cells by targeting G‐quadruplex

2021 ◽  
Author(s):  
Jean Guillon ◽  
Caroline Denevault‐Sabourin ◽  
Edith Chevret ◽  
Marie Brachet‐Botineau ◽  
Vittoria Milano ◽  
...  
Keyword(s):  
Antiproliferative Effect ◽  
Leukemic Cells ◽  
Design Synthesis ◽  
G Quadruplex ◽  
Human Leukemic Cells

Antiproliferative Effect of Gaillardin from Inula oculus-christi in Human Leukemic Cells

2019 ◽  
Vol 72 (6) ◽  
pp. 1043-1056 ◽  
Author(s):  
Afshin Karami ◽  
Maryam Hamzeloo-Moghadam ◽  
Amir Yami ◽  
Mohieddin Barzegar ◽  
Pargol Mashati ◽  
...  
Keyword(s):  
Antiproliferative Effect ◽  
Leukemic Cells ◽  
Human Leukemic Cells

Antiproliferative effect of T/Tn specific Artocarpus lakoocha agglutinin (ALA) on human leukemic cells (Jurkat, U937, K562) and their imaging by QD-ALA nanoconjugate

2008 ◽  
Vol 25 (8) ◽  
pp. 741-752 ◽  
Author(s):  
Urmimala Chatterjee ◽  
Partha Pratim Bose ◽  
Sharmistha Dey ◽  
Tej P. Singh ◽  
Bishnu P. Chatterjee
Keyword(s):  
Antiproliferative Effect ◽  
Leukemic Cells ◽  
Human Leukemic Cells

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

2014 ◽  
Vol 81 ◽  
pp. 341-349 ◽  
Author(s):  
Kothanahally S. Sharath Kumar ◽  
Ananda Hanumappa ◽  
Mahesh Hegde ◽  
Kereyagalahally H. Narasimhamurthy ◽  
Sathees C. Raghavan ◽  
...  
Keyword(s):  
Antiproliferative Effect ◽  
Leukemic Cells ◽  
Human Leukemic Cells

A novel mechanism for imatinib mesylate–induced cell death of BCR-ABL–positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity

Blood ◽  
2004 ◽  
Vol 103 (6) ◽  
pp. 2299-2307 ◽  
Author(s):  
Masayuki Okada ◽  
Souichi Adachi ◽  
Tsuyoshi Imai ◽  
Ken-ichiro Watanabe ◽  
Shin-ya Toyokuni ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Serine Protease ◽  
Imatinib Mesylate ◽  
Protease Activity ◽  
Kinase Inhibitor ◽  
Leukemic Cells ◽  
Endonuclease G ◽  
Serine Protease Activity ◽  
Human Leukemic Cells

Abstract Caspase-independent programmed cell death can exhibit either an apoptosis-like or a necrosis-like morphology. The ABL kinase inhibitor, imatinib mesylate, has been reported to induce apoptosis of BCR-ABL–positive cells in a caspase-dependent fashion. We investigated whether caspases alone were the mediators of imatinib mesylate–induced cell death. In contrast to previous reports, we found that a broad caspase inhibitor, zVAD-fmk, failed to prevent the death of imatinib mesylate–treated BCR-ABL–positive human leukemic cells. Moreover, zVAD-fmk–preincubated, imatinib mesylate–treated cells exhibited a necrosis-like morphology characterized by cellular pyknosis, cytoplasmic vacuolization, and the absence of nuclear signs of apoptosis. These cells manifested a loss of the mitochondrial transmembrane potential, indicating the mitochondrial involvement in this caspase-independent necrosis. We excluded the participation of several mitochondrial factors possibly involved in caspase-independent cell death such as apoptosis-inducing factor, endonuclease G, and reactive oxygen species. However, we observed the mitochondrial release of the serine protease Omi/HtrA2 into the cytosol of the cells treated with imatinib mesylate or zVAD-fmk plus imatinib mesylate. Furthermore, serine protease inhibitors prevented the caspase-independent necrosis. Taken together, our results suggest that imatinib mesylate induces a caspase-independent, necrosis-like programmed cell death mediated by the serine protease activity of Omi/HtrA2.

The impact of lithium on human leukemic cells

1991 ◽  
Vol 15 (8) ◽  
pp. 766 ◽  
Author(s):  
Ronald D. Barr ◽  
Delsworth Harnish
Keyword(s):  
Leukemic Cells ◽  
Human Leukemic Cells ◽  
The Impact

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

Biochemistry ◽  
1988 ◽  
Vol 27 (24) ◽  
pp. 8861-8869 ◽  
Author(s):  
Mary K. Danks ◽  
Carla A. Schmidt ◽  
Margaret C. Cirtain ◽  
D. Parker Suttle ◽  
William T. Beck
Keyword(s):  
Catalytic Activity ◽  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Leukemic Cells ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Leukemic Cells

Immunological Markers of Human Leukemic Cells of the B Lineage

1983 ◽  
pp. 29-43
Author(s):  
M. Seligmann ◽  
L. B. Vogler ◽  
P. Guglielmi ◽  
J. C. Brouet ◽  
J. L. Preud’homme
Keyword(s):  
Leukemic Cells ◽  
Immunological Markers ◽  
B Lineage ◽  
Human Leukemic Cells

Effect of 4-hydroxynonenal on gene expression and differentiation of HL-60 human leukemic cells

1991 ◽  
Vol 27 ◽  
pp. S65 ◽  
Author(s):  
G. Barrera ◽  
R. Muraca ◽  
C. Di Mauro ◽  
V.M. Fazio ◽  
M.U. Dianzani
Keyword(s):  
Gene Expression ◽  
Leukemic Cells ◽  
Human Leukemic Cells
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