scholarly journals Number of pericryptal fibroblasts correlates with density of distinct mast cell phenotypes in the crypt lamina propria of human duodenum: Implications for the homeostasis of villous architecture

2006 ◽  
Vol 288A (6) ◽  
pp. 593-600 ◽  
Author(s):  
Enrico Crivellato ◽  
Nicoletta Finato ◽  
Miriam Isola ◽  
Maura Pandolfi ◽  
Domenico Ribatti ◽  
...  
Keyword(s):  
Mast Cell ◽  
Lamina Propria ◽  
Cell Phenotypes

Phenotypic and Quantitative Changes in Mast Cells after Syngeneic Unilateral Lung Transplantation in the Rat

1996 ◽  
Vol 91 (3) ◽  
pp. 319-327 ◽  
Author(s):  
Annick Buvry ◽  
Monique Garbarg ◽  
Violetta Dimitriadou ◽  
Agnès Rouleau ◽  
George F. J. Newlands ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Lung Transplantation ◽  
Left Lung ◽  
Muscle Layer ◽  
Rat Lung ◽  
Large Airways ◽  
Quantitative Changes ◽  
Cell Phenotypes ◽  
And Control

1. Lung transplantation causes a total interruption of the innervation and vascularization within the transplanted organ, followed by repair processes. This is frequently associated with bronchial hyper-responsiveness. A common feature of tissue repair is an increase in the number of mast cells. Three phenotypically distinct mast cell subsets, with respect to their protease content, have been identified in rat lung, and it is probable that mast cells of differing protease phenotype fulfil different functions. 2. We have compared the number, protease phenotype and distribution of mast cells in left lung from transplanted and control Lewis rats 1 month after syngeneic unilateral left lung transplantation, without interference of inflammation, graft rejection or of any treatment. Connective and mucosal-type mast cell phenotypes were characterized using antibodies directed against their specific rat mast cell proteases, RMCPI and RMCPII, respectively. 3. After transplantation, RMCPI and RMCPII tissue concentrations increased by 172% and 239%, respectively, compared with controls (13.1 ± 1.2 and 5.6±1.0 μg/g). 4. Localization of mast cell phenotypes was studied by immunohistochemistry after double immunostaining. The number of mast cells increased after transplantation: the increase in the number of RMCPI-immunoreactive mast cells (RMCPI+) was significant around bronchioles and arterioles, around large vessels and in the pleura. The number of RMCPII+ mast cells also significantly increased around bronchioles and arterioles, as well as in the smooth muscle layer of large airways. Some mast cells stained for the presence of both RMCPI and RMCPII, supporting the existence of co-expressing phenotype in rat lung. The number of mast cells of the RMCPI+ /H+ phenotype significantly increased around bronchioles and arterioles and in the pleura. Moreover, the distribution of the mast cell phenotypes was modified in the different areas after transplantation. 5. This indicates a local differentiation/maturation of mast cells after transplantation.

scholarly journals Mast cell phenotypes in the allograft after lung transplantation

2016 ◽  
Vol 30 (7) ◽  
pp. 845-851 ◽  
Author(s):  
Amit Banga ◽  
Yingchun Han ◽  
Xiaofeng Wang ◽  
Fred H. Hsieh
Keyword(s):  
Mast Cell ◽  
Lung Transplantation ◽  
Cell Phenotypes

scholarly journals Skin mast cell phenotypes between two highly divergent cohorts - more pronounced variability within than between groups

2017 ◽  
Vol 26 (5) ◽  
pp. 446-449 ◽  
Author(s):  
Magda Babina ◽  
Sven Guhl ◽  
Metin Artuc ◽  
Torsten Zuberbier
Keyword(s):  
Mast Cell ◽  
Skin Mast Cell ◽  
Cell Phenotypes

Mast cell phenotypes and microvessels in non–small cell lung cancer and its prognostic significance

2010 ◽  
Vol 41 (5) ◽  
pp. 697-705 ◽  
Author(s):  
María José Carlini ◽  
Mercedes Corina Liliana Dalurzo ◽  
José María Lastiri ◽  
David Eduardo Smith ◽  
Bartolomé Carlos Vasallo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mast Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Prognostic Significance ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Phenotypes

scholarly journals Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes

2020 ◽  
Author(s):  
Heidi Hempel Sullivan ◽  
Janielle P. Maynard ◽  
Christopher M. Heaphy ◽  
Jiayun Lu ◽  
Angelo M. De Marzo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mast Cell ◽  
Oncologic Outcomes ◽  
Cancer Tissues ◽  
Cell Phenotypes

scholarly journals Mast cell phenotypes in human transplanted kidneys

1998 ◽  
Vol 76 ◽  
pp. 70
Author(s):  
M Yamada ◽  
M Ueda ◽  
T Naruko ◽  
S Tanabe ◽  
S Takai ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Phenotypes ◽  
Transplanted Kidneys

Temporal distribution of distinct mast cell phenotypes during intestinal schistosomiasis in mice

2002 ◽  
Vol 24 (5) ◽  
pp. 225-231 ◽  
Author(s):  
Frederik De Jonge ◽  
Luc Van Nassauw ◽  
Frans Van Meir ◽  
Hugh R. P. Miller ◽  
Eric Van Marck ◽  
...  
Keyword(s):  
Mast Cell ◽  
Temporal Distribution ◽  
Intestinal Schistosomiasis ◽  
Cell Phenotypes

scholarly journals Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine

Blood ◽  
2011 ◽  
Vol 117 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Mamiko Sakata-Yanagimoto ◽  
Toru Sakai ◽  
Yasuyuki Miyake ◽  
Toshiki I. Saito ◽  
Haruhiko Maruyama ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cell ◽  
Small Intestine ◽  
Mast Cells ◽  
Lamina Propria ◽  
Conditional Knockout ◽  
Small Intestinal Mucosa ◽  
Epithelial Layer ◽  
Strongyloides Venezuelensis ◽  
Small Intestinal

Abstract Notch receptor-mediated signaling is involved in the developmental process and functional modulation of lymphocytes, as well as in mast cell differentiation. Here, we investigated whether Notch signaling is required for antipathogen host defense regulated by mast cells. Mast cells were rarely found in the small intestine of wild-type C57BL/6 mice but accumulated abnormally in the lamina propria of the small-intestinal mucosa of the Notch2-conditional knockout mice in naive status. When transplanted into mast cell–deficient Wsh/Wsh mice, Notch2-null bone marrow-derived mast cells were rarely found within the epithelial layer but abnormally localized to the lamina propria, whereas control bone marrow-derived mast cells were mainly found within the epithelial layer. After the infection of Notch2 knockout and control mice with L3 larvae of Strongyloides venezuelensis, the abundant number of mast cells was rapidly mobilized to the epithelial layer in the control mice. In contrast, mast cells were massively accumulated in the lamina propria of the small intestinal mucosa in Notch2-conditional knockout mice, accompanied by impaired eradication of Strongyloides venezuelensis. These findings indicate that cell-autonomous Notch2 signaling in mast cells is required for proper localization of intestinal mast cells and further imply a critical role of Notch signaling in the host-pathogen interface in the small intestine.

Mechanical removal of airway epithelium disrupts mast cells and releases granules

1990 ◽  
Vol 259 (6) ◽  
pp. L372-L377 ◽  
Author(s):  
G. M. Franconi ◽  
I. Rubinstein ◽  
E. H. Levine ◽  
S. Ikeda ◽  
J. A. Nadel
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Lamina Propria ◽  
Airway Epithelium ◽  
Mechanical Deformation ◽  
Enzymatic Digestion ◽  
Cell Integrity ◽  
Mechanical Removal ◽  
Cell Components

Many previous investigators have utilized mechanical rubbing as a method for examining effects of epithelial removal. In the present study, we examined whether this procedure also affects mast cell integrity in the underlying lamina propria. We isolated bronchial rings from six ferrets, and we found that removal of epithelium by rubbing decreased the total number of intact mast cells from 10.0 +/- 1.9 to 2.2 +/- 0.6 (SE) mast cells/mm luminal perimeter (P less than 0.01). In addition, we found a very large number of metachromatic particles that appeared to be mast cell granules unassociated with identifiable mast cells. Their identity was confirmed the presence of free mast cell granules and showed that they contained intact membranes. These effects were not observed when the epithelium was removed by enzymatic digestion, but they were observed after mechanical deformation of the bronchi alone. We suggest that mast cell components released by removing or damaging the epithelium may affect the function of various cells in the airway.

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