scholarly journals Promotion of Peripheral Nerve Regeneration by Stimulation of the Extracellular Signal‐Regulated Kinase (ERK) Pathway

2019 ◽  
Vol 302 (8) ◽  
pp. 1261-1267 ◽  
Author(s):  
Barbara Hausott ◽  
Lars Klimaschewski
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Erk Pathway ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Stimulation Of

Direct Current Electrical Stimulation of Acupuncture Needles for Peripheral Nerve Regeneration: An Exploratory Case Series

2011 ◽  
Vol 29 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Motohiro Inoue ◽  
Yasukazu Katsumi ◽  
Megumi Itoi ◽  
Tatsuya Hojo ◽  
Miwa Nakajima ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Direct Current ◽  
Peripheral Nerve Regeneration ◽  
Case Series ◽  
Stimulation Of

scholarly journals Bionic microenvironment-inspired synergistic effect of anisotropic micro-nanocomposite topology and biology cues on peripheral nerve regeneration

2021 ◽  
Vol 7 (28) ◽  
pp. eabi5812
Author(s):  
Guicai Li ◽  
Tiantian Zheng ◽  
Linliang Wu ◽  
Qi Han ◽  
Yifeng Lei ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Transforming Growth Factor ◽  
Synergistic Effects ◽  
Peripheral Nerve Regeneration ◽  
Transforming Growth Factor Β ◽  
Signal Pathways ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Promising Application

Anisotropic topographies and biological cues can simulate the regenerative microenvironment of nerve from physical and biological aspects, which show promising application in nerve regeneration. However, their synergetic influence on injured peripheral nerve is rarely reported. In the present study, we constructed a bionic microenvironment-inspired scaffold integrated with both anisotropic micro-nanocomposite topographies and IKVAV peptide. The results showed that both the topographies and peptide displayed good stability. The scaffolds could effectively induce the orientation growth of Schwann cells and up-regulate the genes and proteins relevant to myelination. Last, three signal pathways including the Wnt/β-catenin pathway, the extracellular signal–regulated kinase/mitogen-activated protein pathway, and the transforming growth factor–β pathway were put forward, revealing the main path of synergistic effects of anisotropic micro-nanocomposite topographies and biological cues on neuroregeneration. The present study may supply an important strategy for developing functional of artificial nerve implants.

Magnetic Nanoparticles for Efficient Delivery of Growth Factors: Stimulation of Peripheral Nerve Regeneration

2017 ◽  
Vol 6 (7) ◽  
pp. 1601429 ◽  
Author(s):  
Martina Giannaccini ◽  
M. Pilar Calatayud ◽  
Andrea Poggetti ◽  
Silvia Corbianco ◽  
Michela Novelli ◽  
...  
Keyword(s):  
Growth Factors ◽  
Magnetic Nanoparticles ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Efficient Delivery ◽  
Stimulation Of

Modern approaches to peripheral nerve regeneration after injury: the prospects of gene and cell therapy

2017 ◽  
Author(s):  
M. Karagyaur ◽  
P. Makarevich ◽  
E. Shevchenko ◽  
D. Stambolsky ◽  
N. Kalinina ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Gene And Cell Therapy
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