Magnetic Nanoparticles for Efficient Delivery of Growth Factors: Stimulation of Peripheral Nerve Regeneration

2017 ◽  
Vol 6 (7) ◽  
pp. 1601429 ◽  
Author(s):  
Martina Giannaccini ◽  
M. Pilar Calatayud ◽  
Andrea Poggetti ◽  
Silvia Corbianco ◽  
Michela Novelli ◽  
...  
Keyword(s):  
Growth Factors ◽  
Magnetic Nanoparticles ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Efficient Delivery ◽  
Stimulation Of

Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration

2016 ◽  
Vol 17 (2) ◽  
pp. 197-212 ◽  
Author(s):  
Mikel Sánchez ◽  
Eduardo Anitua ◽  
Diego Delgado ◽  
Peio Sanchez ◽  
Roberto Prado ◽  
...  
Keyword(s):  
Growth Factors ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Platelet Rich Plasma ◽  
Peripheral Nerve Regeneration ◽  
Biomimetic Scaffold

Direct Current Electrical Stimulation of Acupuncture Needles for Peripheral Nerve Regeneration: An Exploratory Case Series

2011 ◽  
Vol 29 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Motohiro Inoue ◽  
Yasukazu Katsumi ◽  
Megumi Itoi ◽  
Tatsuya Hojo ◽  
Miwa Nakajima ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Direct Current ◽  
Peripheral Nerve Regeneration ◽  
Case Series ◽  
Stimulation Of

scholarly journals Identification of critical growth factors for peripheral nerve regeneration

RSC Advances ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 10760-10765 ◽  
Author(s):  
Ruirui Zhang ◽  
Yan Zhang ◽  
Sheng Yi
Keyword(s):  
Growth Factors ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerves ◽  
Peripheral Nerve Regeneration ◽  
Critical Growth

Growth factors are essential for the repair and regeneration of tissues and organs, including injured peripheral nerves.

GELATIN-TRICALCIUM PHOSPHATE MEMBRANE MODIFIED WITH NGF AND CULTURED SCHWANN CELLS FOR PERIPHERAL NERVE REPAIR: A TISSUE ENGINEERING APPROACH

2006 ◽  
Vol 18 (02) ◽  
pp. 47-54 ◽  
Author(s):  
MING-HONG CHEN ◽  
PEI-RU CHEN ◽  
MEI-HSIU CHEN ◽  
SUNG-TSANG HSIEH ◽  
JING-SHAN HUANG ◽  
...  
Keyword(s):  
Growth Factors ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Tricalcium Phosphate ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Nerve Growth ◽  
Nerve Growth Factors ◽  
Cultured Schwann Cells

This study attempted to enhance the efficacy of peripheral nerve regeneration using our previously developed gelatin-tricalcium phosphate (GTG) conduits by incorporating them with nerve growth factors and cultured Schwann cells. The nerve growth factors were covalently immobilized onto the GTG conduits (GEN) using carbodiimide. Schwann cells were harvested from neonatal Lewis rats, cultured for seven days and injected into the GEN conduits. The experiment was performed in three groups: GTG conduits, GEN conduits and GEN conduits with Schwann cells injected (GEN+Sc). The effects of different conduits (GTG, GEN and GEN with Schwann cells) on the peripheral nerve regeneration were evaluated in rat sciatic nerve repair model. 24 weeks after implantation of conduits, degradation of the conduits in all groups was illustrated by the fragmentation of the conduits. All conduits were well tolerated by the host tissue. Under microscopic evaluations, regenerated nerve tissue with myelinated and unmyelinated axons presented in all groups. Histomorphometrically, the total nerve area of GEN+Sc group was significantly higher than GTG group. Conversely, the autotomy score evaluated 12 weeks after nerve repair showed better results for GTG group. Besides, GEN+Sc group had the highest average recovery index of compound muscle action potential, but the difference among each group did not reach statistical significance. Although the electrophysiological recovery of nerve was not significantly improved with GEN+Sc conduit, nerve repair using tissue engineered conduits still provided better histological results. However, it should be noticed that autotomy may be the price paid for enhanced peripheral nerve.

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