scholarly journals Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle-in-Vein Grafts

2018 ◽  
Vol 301 (10) ◽  
pp. 1697-1713 ◽  
Author(s):  
Maria Stößel ◽  
Vivien M. Wildhagen ◽  
Olaf Helmecke ◽  
Jennifer Metzen ◽  
Charlotte B. Pfund ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Comparative Evaluation ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Vein Grafts ◽  
Nerve Grafts ◽  
Nerve Guides ◽  
Comprehensive Comparison

Inside-out and Standard Vein Grafts, with or without Muscle Filling, in Peripheral Nerve Repair: A Histomorphometric Study

2016 ◽  
Vol 13 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Domingos Roque ◽  
Karina Pomini ◽  
Rogério Buchaim ◽  
Daniela Buchaim ◽  
Jesus Andreo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Vein Grafts ◽  
Histomorphometric Study ◽  
Inside Out

scholarly journals Techniques of Peripheral Nerve Repair

2008 ◽  
Vol 97 (4) ◽  
pp. 310-316 ◽  
Author(s):  
L. B. Dahlin
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Correct Diagnosis ◽  
Nerve Injuries ◽  
Nerve Roots ◽  
Postoperative Rehabilitation ◽  
Cold Intolerance ◽  
Peripheral Nerve Repair ◽  
Nerve Grafts ◽  
Nerve Transfers

Nerve injuries extend from simple nerve compression lesions to complete nerve injuries and severe lacerations of the nerve trunks. A specific problem is brachial plexus injuries where nerve roots can be ruptured, or even avulsed from the spinal cord, by traction. An early and correct diagnosis of a nerve injury is important. A thorough knowledge of the anatomy of the peripheral nerve trunk as well as of basic neurobiological alterations in neurons and Schwann cells induced by the injury are crucial for the surgeon in making adequate decisions on how to repair and reconstruct nerves. The technique of peripheral nerve repair includes four important steps (preparation of nerve end, approximation, coaptation and maintenance). Nerves are usually repaired primarily with sutures applied in the different tissue components, but various tubes are available. Nerve grafts and nerve transfers are alternatives when the injury induces a nerve defect. Timing of nerve repair is essential. An early repair is preferable since it is advantageous for neurobiological reasons. Postoperative rehabilitation, utilising the patients' own coping strategies, with evaluation of outcome are additional important steps in treatment of peripheral nerve injuries. In the rehabilitation phase adequate handling of pain, allodynia and cold intolerance are emphasised.

scholarly journals The Use of Degradable Nerve Conduits for Human Nerve Repair: A Review of the Literature

2005 ◽  
Vol 2 (1) ◽  
pp. 39-43 ◽  
Author(s):  
M. F. Meek ◽  
K. Jansen ◽  
P. H. Robinson
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Nerve Repair ◽  
Experimental Studies ◽  
Review Of The Literature ◽  
Nerve Grafts ◽  
Nerve Guides ◽  
Clinical Challenge ◽  
Nerve Conduits ◽  
Human Nerve

The management of peripheral nerve injury continues to be a major clinical challenge. The most widely used technique for bridging defects in peripheral nerves is the use of autologous nerve grafts. This technique, however, has some disadvantages. Many alternative experimental techniques have thus been developed, such as degradable nerve conduits. Degradable nerve guides have been extensively studied in animal experimental studies. However, the repair of human nerves by degradable nerve conduits has been limited to only a few clinical studies. In this paper, an overview of the available international published literature on degradable nerve conduits for bridging human peripheral nerve defects is presented for literature available until 2004. Also, the philosophy on the use of nerve guides and nerve grafts is given.

Exosomes as a promising therapeutic strategy for peripheral nerve injury

2021 ◽  
Vol 19 ◽  
Author(s):  
Tianhao Yu ◽  
Yingxi Xu ◽  
Muhammad Arslan Ahmad ◽  
Rabia Javed ◽  
Haruo Hagiwara ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Nerve Grafts ◽  
Axonal Regrowth ◽  
Vascular Regeneration

Peripheral nerve injury has a high incidence and often leads to severe losses of sensory and motor functions in the afflicted limb. Autologous nerve grafts are widely accepted as the gold standard for peripheral nerve repair, but the presence of inherent drawbacks dramatically reduces their usability. Numerous tissue engineering nerve grafts are developed as alternatives of autologous nerve grafts, and a variety of cells and neurotrophic factors were introduced into these grafts for improvement. However, they are still difficult to obtain satisfactory clinical results. Peripheral nerve regeneration following injury remains a significant challenge for researchers and clinicians. Exosomes are extracellular membranous nanovesicles that are secreted by most cells. As the key players of intercellular communication, exosomes play a fundamental role in the physiological and pathological processes of the nervous system. Accumulating evidence has suggested that exosomes can exert neurotherapeutic effects via mediating axonal regrowth, Schwann cell activation, vascular regeneration, and inflammatory regulation. Exosomes are emerging as a promising approach for treating peripheral nerve injury. Furthermore, they also provide possibilities for enhancing the repair capacity of various nerve grafts. This review primarily highlights the regenerative effects of exosomes on peripheral nerve injury. The exosomes from distinct sources reported so far in literature are summarized to understand their roles in the process of nerve repair. Moreover, the challenges that must be addressed in their clinical transformation are outlined as well. This review also provides further insight into the potential application of exosomes for peripheral nerve repair. Keywords: Exosome, nerve regeneration, peripheral nerve injury, Schwann cell, axonal regrowth, inflammation, vascular regeneration.

scholarly journals Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair

Biomaterials ◽  
2015 ◽  
Vol 49 ◽  
pp. 77-89 ◽  
Author(s):  
Christopher J. Pateman ◽  
Adam J. Harding ◽  
Adam Glen ◽  
Caroline S. Taylor ◽  
Claire R. Christmas ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Nerve Guides

Collagen—Chitosan Nerve Guides for Peripheral Nerve Repair: A Histomorphometric Study

2008 ◽  
Vol 23 (2) ◽  
pp. 101-121 ◽  
Author(s):  
Minal Patel ◽  
Pamela J. Vandevord ◽  
Howard W. Matthew ◽  
Stephen De Silva ◽  
Bin Wu ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Histomorphometric Study ◽  
Nerve Guides

Techniques of Peripheral Nerve Repair

1991 ◽  
Vol 2 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Mark E. Harris ◽  
Suzie C. Tindall
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair
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