Ethylene Oxide Sterilization Preserves Bioactivity and Attenuates Burst Release of Encapsulated Glial Cell Line Derived Neurotrophic Factor from Tissue Engineered Nerve Guides For Long Gap Peripheral Nerve Repair

2015 ◽  
Vol 1 (7) ◽  
pp. 504-512 ◽  
Author(s):  
J. M. Bliley ◽  
W. N. Sivak ◽  
D. M. Minteer ◽  
C. Tompkins-Rhoades ◽  
J. Day ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Peripheral Nerve ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Nerve Repair ◽  
Burst Release ◽  
Peripheral Nerve Repair ◽  
Nerve Guides ◽  
Ethylene Oxide Sterilization

scholarly journals Characterization of glial cell line-derived neurotrophic factor family receptor α-1 in peripheral nerve Schwann cells

2005 ◽  
Vol 95 (2) ◽  
pp. 537-543 ◽  
Author(s):  
Asako Hase ◽  
Fumiaki Saito ◽  
Hiroki Yamada ◽  
Ken Arai ◽  
Teruo Shimizu ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cell Line ◽  
Glial Cell ◽  
Schwann Cells ◽  
Neurotrophic Factor

scholarly journals The differential effects of pathway- versus target-derived glial cell line–derived neurotrophic factor on peripheral nerve regeneration

2010 ◽  
Vol 113 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Christina K. Magill ◽  
Amy M. Moore ◽  
Ying Yan ◽  
Alice Y. Tong ◽  
Matthew R. MacEwan ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Nerve Fibers ◽  
Sciatic Nerve Crush ◽  
Fiber Density ◽  
Nerve Crush ◽  
Differential Effects

Object Glial cell line–derived neurotrophic factor (GDNF) has potent survival effects on central and peripheral nerve populations. The authors examined the differential effects of GDNF following either a sciatic nerve crush injury in mice that overexpressed GDNF in the central or peripheral nervous systems (glial fibrillary acidic protein [GFAP]–GDNF) or in the muscle target (Myo-GDNF). Methods Adult mice (GFAP-GDNF, Myo-GDNF, or wild-type [WT] animals) underwent sciatic nerve crush and were evaluated using histomorphometry and muscle force and power testing. Uninjured WT animals served as controls. Results In the sciatic nerve crush, the Myo-GDNF mice demonstrated a higher number of nerve fibers, fiber density, and nerve percentage (p < 0.05) at 2 weeks. The early regenerative response did not result in superlative functional recovery. At 3 weeks, GFAP-GDNF animals exhibit fewer nerve fibers, decreased fiber width, and decreased nerve percentage compared with WT and Myo-GDNF mice (p < 0.05). By 6 weeks, there were no significant differences between groups. Conclusions Peripheral delivery of GDNF resulted in earlier regeneration following sciatic nerve crush injuries than that with central GDNF delivery. Treatment with neurotrophic factors such as GDNF may offer new possibilities for the treatment of peripheral nerve injury.

scholarly journals Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair

Biomaterials ◽  
2015 ◽  
Vol 49 ◽  
pp. 77-89 ◽  
Author(s):  
Christopher J. Pateman ◽  
Adam J. Harding ◽  
Adam Glen ◽  
Caroline S. Taylor ◽  
Claire R. Christmas ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Nerve Guides
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