scholarly journals Protective Effect of Quercetin on Cadmium-Induced Oxidative Toxicity on Germ Cells in Male Mice

2010 ◽  
Vol 294 (3) ◽  
pp. 520-526 ◽  
Author(s):  
Tongliang Bu ◽  
Yuling Mi ◽  
Weidong Zeng ◽  
Caiqiao Zhang
Keyword(s):  
Protective Effect ◽  
Germ Cells ◽  
Male Mice

scholarly journals PROTECTIVE EFFECT OF FOLIC ACID ON OXIDATIVE STRESS INDUCED BY METHIONINE OVERLOAD IN MALE MICE

2021 ◽  
Vol 21 (Suppliment-1) ◽  
pp. 1430-1434
Author(s):  
Tuqa Sabbar Rahi ◽  
Wifaq j. albazi ◽  
Ali K. Aljarah ◽  
Alaa Hussein AL-Safy
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Protective Effect ◽  
Male Mice

The mutagenic effect of cytosine arabinoside on germ cells of male mice

1981 ◽  
Vol 85 (4) ◽  
pp. 299 ◽  
Author(s):  
J. Pečevski ◽  
D. Radivojević ◽  
N. Savković ◽  
Lj. Vuksanović ◽  
P. Cvetković
Keyword(s):  
Germ Cells ◽  
Cytosine Arabinoside ◽  
Mutagenic Effect ◽  
Male Mice

Protective Effect of Calcium Dobesilate Administration Against Hepatorenal Damage Induced By CCL4 In Male Mice

2021 ◽  
Author(s):  
Elham Hakimizadeh ◽  
Ayat Kaeidi ◽  
Mohammadreza Rahmani ◽  
Mohammad Allahtavakoli ◽  
Jalal Hassanshahi
Keyword(s):  
Protective Effect ◽  
Antioxidant Properties ◽  
Group Versus ◽  
Histopathological Change ◽  
Renal Tissue ◽  
Protective Effects ◽  
Male Mice ◽  
Calcium Dobesilate ◽  
Liver And Kidney ◽  
Anti Inflammatory

Abstract Purpose: Calcium dobesilate (CaD) has antioxidant and anti-inflammatory properties. In this study, the protective effects of CaD against hepatorenal damage induced by CCL4 in male mice were evaluated. Methods: Thirty male mice randomly were divided into five groups: Control, CaD 100 mg/kg, CCL4, CCL4+CaD 50 mg/kg, and CCL4+CaD 100 mg/kg. Drugs were administered orally once a day for 4-weeks. The liver and kidney indices (serum creatinine, blood urine nitrogen, alanine aminotransferase and aspartate aminotransferase levels) were determined. Also, hepatic and renal tissue oxidant/antioxidant markers (glutathione peroxidase, malondialdehyde, total antioxidant capacity, and superoxide dismutase) were measured. Cleaved caspase-3, Bax, and Bcl-2 protein levels were measured by immunoblotting method. The liver and kidney histopathological changes were evaluated by H&E staining.Results: CCL4 induces significant oxidative stress in the kidney and liver that was concomitant with functional and histopathological abnormalities in these organs in the CCL4 group versus the control (P<0.05). CaD could significantly improve the histopathological change in the liver and kidney tissues of CCL4+CaD 100 mg/kg mice versus the CCL4 group (P<0.05). In addition, CaD attenuated apoptosis in the liver and kidney tissues (P<0.05).Conclusion: The protective effect of CaD may be related to its anti-inflammatory and antioxidant properties.

scholarly journals Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice

2011 ◽  
Vol 22 (10) ◽  
pp. 1766-1779 ◽  
Author(s):  
Karina Kaczmarek ◽  
Maja Studencka ◽  
Andreas Meinhardt ◽  
Krzysztof Wieczerzak ◽  
Sven Thoms ◽  
...  
Keyword(s):  
Cell Death ◽  
Germ Cell ◽  
Germ Cells ◽  
Specific Gene ◽  
Male Mice ◽  
Terminal Part ◽  
Male Germ Cells ◽  
Germ Cell Apoptosis ◽  
Induced Apoptosis

 Peroxisomal testis-specific 1 gene (Pxt1) is the only male germ cell–specific gene that encodes a peroxisomal protein known to date. To elucidate the role of Pxt1 in spermatogenesis, we generated transgenic mice expressing a c-MYC-PXT1 fusion protein under the control of the PGK2 promoter. Overexpression of Pxt1 resulted in induction of male germ cells’ apoptosis mainly in primary spermatocytes, finally leading to male infertility. This prompted us to analyze the proapoptotic character of mouse PXT1, which harbors a BH3-like domain in the N-terminal part. In different cell lines, the overexpression of PXT1 also resulted in a dramatic increase of apoptosis, whereas the deletion of the BH3-like domain significantly reduced cell death events, thereby confirming that the domain is functional and essential for the proapoptotic activity of PXT1. Moreover, we demonstrated that PXT1 interacts with apoptosis regulator BAT3, which, if overexpressed, can protect cells from the PXT1-induced apoptosis. The PXT1-BAT3 association leads to PXT1 relocation from the cytoplasm to the nucleus. In summary, we demonstrated that PXT1 induces apoptosis via the BH3-like domain and that this process is inhibited by BAT3.

Normal fertility in male mice with deletion of β-catenin gene in germ cells

genesis ◽  
2014 ◽  
Vol 52 (4) ◽  
pp. 328-332 ◽  
Author(s):  
Bryan Rivas ◽  
Zaohua Huang ◽  
Alexander I. Agoulnik
Keyword(s):  
Germ Cells ◽  
Male Mice ◽  
Normal Fertility

Protective effect of gallic acid on apoptosis of sperm and in vitro fertilization in adult male mice treated with cyclophosphamide

2019 ◽  
Vol 120 (10) ◽  
pp. 17250-17257 ◽  
Author(s):  
Zahra Mehraban ◽  
Marefat Ghaffari Novin ◽  
Mohammad Ghasem Golmohammadi ◽  
Mohsen Sagha ◽  
Khashayar Pouriran ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Protective Effect ◽  
Gallic Acid ◽  
Adult Male ◽  
Male Mice ◽  
Vitro Fertilization
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