scholarly journals Immunohistochemical Localization of Substance P And Cholecystokinin in the Dorsal Root Ganglia and Spinal Cord of the Bottlenose Dolphin (Tursiops truncatus)

2010 ◽  
Vol 293 (3) ◽  
pp. 477-484 ◽  
Author(s):  
Cristiano Bombardi ◽  
Annamaria Grandis ◽  
Alice Nenzi ◽  
Maristella Giurisato ◽  
Bruno Cozzi
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Root Ganglia ◽  
Bottlenose Dolphin ◽  
Dorsal Root ◽  
Tursiops Truncatus ◽  
Immunohistochemical Localization

Distribution of substance P-like immunoreactivity in the spinal cord and dorsal root ganglia of the human foetus and infant

Neuroscience ◽  
1983 ◽  
Vol 10 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Y. Charnay ◽  
C. Paulin ◽  
J.-A. Chayvialle ◽  
P.M. Dubois
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Human Foetus

scholarly journals Sensation of Abdominal Pain Induced by Peritoneal Carcinomatosis Is Accompanied by Changes in the Expression of Substance P and μ-Opioid Receptors in the Spinal Cord of Mice

2012 ◽  
Vol 117 (4) ◽  
pp. 847-856 ◽  
Author(s):  
Masami Suzuki ◽  
Minoru Narita ◽  
Minami Hasegawa ◽  
Sadayoshi Furuta ◽  
Tomoyuki Kawamata ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Abdominal Pain ◽  
Substance P ◽  
Peritoneal Carcinomatosis ◽  
Opioid Receptor ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Receptor Expression ◽  
Tumor Bearing ◽  
Μ Opioid Receptor

Background Patients with peritoneal carcinomatosis often report abdominal pain, which is relatively refractory to morphine. It has been considered that a new animal model is required to investigate the mechanism of abdominal pain for the development of optimal treatments for this type of pain. Methods To prepare a peritoneal carcinomatosis model, highly peritoneal-seeding gastric cancer cells, 60As6, were implanted into the abdominal cavity. The nociceptive modality for pain-related behavior was assessed in terms of withdrawal behavior in response to mechanical stimuli and hunching behavior. Tissue samples from mouse dorsal root ganglia and spinal cord were subject to immunohistochemistry and real-time reverse transcription polymerase chain reaction. Results Mice with peritoneal dissemination showed significant hypersensitivity of the abdomen to mechanical stimulation and spontaneous visceral pain-related behavior. There was a significant increase in c-Fos-positive cells in the spinal cord in tumor-bearing mice. Those mice exhibited a remarkable increase in substance P-positive neurons in the dorsal root ganglia (control vs. tumor, 15.4 ± 1.1 vs. 24.2 ± 3.6, P < 0.05, n = 3). A significant decreases in μ-opioid receptor expression mainly in substance P-positive neurons was observed in tumor-bearing mice (69.3 ± 4.9 vs. 38.7 ± 0.9, P < 0.05, n = 3), and a relatively higher dose of morphine was required to significantly reverse the abdominal hypersensitivity. Conclusion Both the up-regulation of substance P and down-regulation of μ-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis.

scholarly journals Distribution of Nitrergic Neurons in the Dorsal Root Ganglia of the Bottlenose Dolphin (Tursiops truncatus)

2011 ◽  
Vol 294 (6) ◽  
pp. 1066-1073 ◽  
Author(s):  
Cristiano Bombardi ◽  
Bruno Cozzi ◽  
Alice Nenzi ◽  
Sandro Mazzariol ◽  
Annamaria Grandis
Keyword(s):  
Dorsal Root Ganglia ◽  
Bottlenose Dolphin ◽  
Dorsal Root ◽  
Tursiops Truncatus
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