A quantitative study of myonuclear and satellite cell nuclear size in Duchenne's muscular dystrophy, polymyositis and normal human skeletal muscle

1988 ◽  
Vol 222 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Simon C. Watkins ◽  
Michael J. Culien
Keyword(s):  
Skeletal Muscle ◽  
Muscular Dystrophy ◽  
Satellite Cell ◽  
Quantitative Study ◽  
Human Skeletal Muscle ◽  
Nuclear Size ◽  
Normal Human ◽  
Duchenne's Muscular Dystrophy

Verapamil and calcium-stimulated enzyme efflux from skeletal muscle.

1982 ◽  
Vol 28 (7) ◽  
pp. 1482-1484 ◽  
Author(s):  
R Anand ◽  
A E Emery
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Muscular Dystrophy ◽  
Human Skeletal Muscle ◽  
Biochemical Abnormality ◽  
Calcium Blocker ◽  
Normal Human ◽  
Duchenne's Muscular Dystrophy

Abstract An early and significant biochemical abnormality in Duchenne's muscular dystrophy is an increase in intracellular calcium. We have found that the "calcium-blocker" drug verapamil inhibits calcium-stimulated efflux of creatine kinase (EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) in vitro from normal human skeletal muscle at therapeutic concentrations. Such a calcium blocker might therefore be useful in the treatment of Duchenne's muscular dystrophy.

[3H]Nitrendipine receptors as markers of a class of putative voltage-sensitive Ca2+ channels in normal human skeletal muscle and in muscle from duchenne muscular dystrophy patients

1986 ◽  
Vol 9 (2) ◽  
pp. 148-151 ◽  
Author(s):  
Claude Desnuelle ◽  
Jean-Fran�ois Renaud ◽  
Eric Delpont ◽  
Georges Serratrice ◽  
Renaud Delpont Lazdunski ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Human Skeletal Muscle ◽  
Normal Human ◽  
Ca2 Channels

scholarly journals THE DISTRIBUTION OF LACTATE DEHYDROGENASE ISOZYMES IN HUMAN SKELETAL MUSCLE FIBERS

1964 ◽  
Vol 12 (8) ◽  
pp. 608-614 ◽  
Author(s):  
M. VAN WIJHE ◽  
M. C. BLANCHAER ◽  
S. ST. GEORGE-STUBBS
Keyword(s):  
Skeletal Muscle ◽  
Lactate Dehydrogenase ◽  
Human Skeletal Muscle ◽  
Muscle Fibers ◽  
Isozyme Pattern ◽  
Electrophoretic Separation ◽  
Lactate Dehydrogenase Isozymes ◽  
Dehydrogenase Isozyme ◽  
Lactate Dehydrogenase Isozyme ◽  
Normal Human

A study of the distribution of lactate dehydrogenase isozymes in single fibers from normal human skeletal muscle is presented. The fibers were classified into red, intermediate and white types on histochemical grounds and their lactate dehydrogenase isozyme content assessed by electrophoretic separation in veronal buffered agar. The results generally agreed with previous homogenate studies on animal skeletal muscle, in that the white fibers contained almost exclusively isozymes IV and V, whereas red fibers were rich in isozymes I, II and III, but IV and V also appeared indigenous to these fibers. The intermediate fibers had an isozyme pattern combining the features of red and white fibers. The metabolic implications of these findings are discussed.

The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle

Nature ◽  
1988 ◽  
Vol 333 (6172) ◽  
pp. 466-469 ◽  
Author(s):  
Elizabeth E. Zubrzycka-Gaarn ◽  
Dennis E. Bulman ◽  
George Karpati ◽  
Arthur H. M. Burghes ◽  
Bonnie Belfall ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Gene Product ◽  
Human Skeletal Muscle ◽  
Duchenne Muscular Dystrophy Gene

scholarly journals Muscular dystrophy in a dish: engineered human skeletal muscle mimetics for disease modeling and drug discovery

2016 ◽  
Vol 21 (9) ◽  
pp. 1387-1398 ◽  
Author(s):  
Alec S.T. Smith ◽  
Jennifer Davis ◽  
Gabsang Lee ◽  
David L. Mack ◽  
Deok-Ho Kim
Keyword(s):  
Skeletal Muscle ◽  
Drug Discovery ◽  
Muscular Dystrophy ◽  
Human Skeletal Muscle ◽  
Disease Modeling
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