Bone-marrow reactions. III. The blood count in the albino rat: Leucocytes, with special reference to the Arneth count

1930 ◽  
Vol 45 (1) ◽  
pp. 69-81 ◽  
Author(s):  
Stuart L. Vaughan ◽  
Francis D. Gunn
Keyword(s):  
Bone Marrow ◽  
Special Reference ◽  
Blood Count ◽  
Albino Rat

Bone-marrow reactions. I. The blood count in the albino rat: Erythrocytes and hemoglobin

1930 ◽  
Vol 44 (4) ◽  
pp. 335-347 ◽  
Author(s):  
Stuart L. Vaughan ◽  
Francis D. Gunn
Keyword(s):  
Bone Marrow ◽  
Blood Count ◽  
Rat Erythrocytes ◽  
Albino Rat

Bone-marrow reactions. II. The blood count in the albino rat: Blood platelets

1930 ◽  
Vol 45 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Francis D. Gunn ◽  
Stuart L. Vaughan
Keyword(s):  
Bone Marrow ◽  
Blood Count ◽  
Blood Platelets ◽  
Albino Rat ◽  
Rat Blood

Diagnostic techniques in the assessment of haematological malignancies

2020 ◽  
pp. 5181-5188
Author(s):  
Wendy N. Erber
Keyword(s):  
Bone Marrow ◽  
Blood Count ◽  
Molecular Genetic ◽  
Diagnostic Techniques ◽  
Blood Film ◽  
Clinical Samples ◽  
Clinical Relapse ◽  
Haematological Malignancies ◽  
Prognostic Prediction ◽  
Detection Of Mutations

The diagnosis of haematological malignancies requires an understanding of the diseases and the uses and limitations of the range of available investigations. The relative importance of different investigations varies by disease entity. The blood count is one of the most widely used tests in all of medicine and often the first indication of an underlying haematological malignancy. Some blood count features are ‘diagnostic’ and others may give an indication of a bone marrow defect. Morphological assessment of a stained blood film adds value to an abnormal blood count. It may identify abnormal morphology of red cells, leucocytes, or platelets which may be specific and diagnostic, or give clues suggesting a diagnosis. Bone marrow aspirate (liquid sample) gives cytological detail, and trephine biopsy provides information about marrow cellularity, architecture, cellular distribution, and extent of fibrosis. Immunophenotyping detects cellular antigens in clinical samples and is essential in the diagnosis and classification of haematological malignancies. It is also used for disease staging and monitoring, to detect surrogate markers of genetic aberrations, identify potential immunotherapeutic targets, and to aid prognostic prediction. Cytogenetics assesses the number and structure of whole chromosomes and chromosomal regions in neoplastic cells and is performed to diagnose and classify some haematological malignancies. Molecular genetic methods facilitate the detection of mutations, rearrangements, or translocations in genes. Applications in malignant haematology include confirming clonality, detecting disease-associated genotypes, determining prognosis, disease monitoring following therapy, predicting imminent clinical relapse, and identifying patients who are likely (or not) to respond to new targeted inhibitor therapies.

scholarly journals FEMORAL BONE MARROW BIOPSY IN THE ALBINO RAT

Blood ◽  
1948 ◽  
Vol 3 (3) ◽  
pp. 292-294 ◽  
Author(s):  
D. G. CAMERON ◽  
G. M. WATSON
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Femoral Bone ◽  
Albino Rat ◽  
Femoral Bone Marrow ◽  
Differential Counts

Abstract A technic for repeated femoral bone marrow biopsy in the rat is detailed. Differential counts confirmed the distribution of the cellular elements as described by other authors.

Sign in / Sign up

Export Citation Format

Share Document