Bone-marrow reactions. II. The blood count in the albino rat: Blood platelets

1930 ◽  
Vol 45 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Francis D. Gunn ◽  
Stuart L. Vaughan
Keyword(s):  
Bone Marrow ◽  
Blood Count ◽  
Blood Platelets ◽  
Albino Rat ◽  
Rat Blood

Bone-marrow reactions. I. The blood count in the albino rat: Erythrocytes and hemoglobin

1930 ◽  
Vol 44 (4) ◽  
pp. 335-347 ◽  
Author(s):  
Stuart L. Vaughan ◽  
Francis D. Gunn
Keyword(s):  
Bone Marrow ◽  
Blood Count ◽  
Rat Erythrocytes ◽  
Albino Rat

Platelet Adhesion to Native Collagens Involves Proteoglycans and May Be a Two-Step Process

1987 ◽  
Vol 58 (02) ◽  
pp. 786-789 ◽  
Author(s):  
O Behnke
Keyword(s):  
Electron Microscope ◽  
Platelet Adhesion ◽  
Close Contact ◽  
Blood Platelets ◽  
Collagen Fibrils ◽  
Platelet Membrane ◽  
Step Process ◽  
Rat Blood ◽  
Wide Gap ◽  
Rat Tail

SummaryAdhesion of rat blood platelets to native rat tail collagen fibrils was studied in the electron microscope under conditions that preserved collagen-associated proteoglycans (CAPG). The CAPG molecules were aligned in chain-like configurations that encircled the fibrils with a 65 nm period; they appeared to coat the fibrils completely and extended 60-100 nm away from the fibril. The initial platelet-fibril contact occurred between the platelet glycocalyx and the CAPG of the fibrils i.e. between two surfaces with net-negative charges. When close contact was established between the fibril surface proper and the platelet membrane, CAPG were not identified in the area of contact, and the collagen-platelet distance was reduced to a ~10-12 nm wide gap traversed by delicate links in register with fibril periodicities.

Platelet microparticles are released from blood platelets and bone marrow cells and stimulate endothelial invasion and neovascularisation

2006 ◽  
Vol 45 (3) ◽  
pp. e120-e121
Author(s):  
Lukasz Partyka ◽  
Joanna Grzybowska ◽  
Urszula Czech ◽  
Anna Polus ◽  
Lukasz Wator ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Blood Platelets ◽  
Platelet Microparticles ◽  
Marrow Cells

Properties of [3H]diazepam binding sites on rat blood platelets

Life Sciences ◽  
1980 ◽  
Vol 27 (20) ◽  
pp. 1881-1888 ◽  
Author(s):  
James K.T. Wang ◽  
Takashi Taniguchi ◽  
Sydney Spector
Keyword(s):  
Binding Sites ◽  
Blood Platelets ◽  
Rat Blood

Diagnostic techniques in the assessment of haematological malignancies

2020 ◽  
pp. 5181-5188
Author(s):  
Wendy N. Erber
Keyword(s):  
Bone Marrow ◽  
Blood Count ◽  
Molecular Genetic ◽  
Diagnostic Techniques ◽  
Blood Film ◽  
Clinical Samples ◽  
Clinical Relapse ◽  
Haematological Malignancies ◽  
Prognostic Prediction ◽  
Detection Of Mutations

The diagnosis of haematological malignancies requires an understanding of the diseases and the uses and limitations of the range of available investigations. The relative importance of different investigations varies by disease entity. The blood count is one of the most widely used tests in all of medicine and often the first indication of an underlying haematological malignancy. Some blood count features are ‘diagnostic’ and others may give an indication of a bone marrow defect. Morphological assessment of a stained blood film adds value to an abnormal blood count. It may identify abnormal morphology of red cells, leucocytes, or platelets which may be specific and diagnostic, or give clues suggesting a diagnosis. Bone marrow aspirate (liquid sample) gives cytological detail, and trephine biopsy provides information about marrow cellularity, architecture, cellular distribution, and extent of fibrosis. Immunophenotyping detects cellular antigens in clinical samples and is essential in the diagnosis and classification of haematological malignancies. It is also used for disease staging and monitoring, to detect surrogate markers of genetic aberrations, identify potential immunotherapeutic targets, and to aid prognostic prediction. Cytogenetics assesses the number and structure of whole chromosomes and chromosomal regions in neoplastic cells and is performed to diagnose and classify some haematological malignancies. Molecular genetic methods facilitate the detection of mutations, rearrangements, or translocations in genes. Applications in malignant haematology include confirming clonality, detecting disease-associated genotypes, determining prognosis, disease monitoring following therapy, predicting imminent clinical relapse, and identifying patients who are likely (or not) to respond to new targeted inhibitor therapies.

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