Forcespun polyvinylpyrrolidone/copper and polyethylene oxide/copper composite fibers and their use as antibacterial agents

2021 ◽  
pp. 51773
Author(s):  
Md Toukir Hasan ◽  
Ramiro Gonzalez ◽  
Ari Alexis Munoz ◽  
Luis Materon ◽  
Jason G. Parsons ◽  
...  
Nanoscale ◽  
2011 ◽  
Vol 3 (10) ◽  
pp. 4215 ◽  
Author(s):  
Geng Xu ◽  
Jingna Zhao ◽  
Shan Li ◽  
Xiaohua Zhang ◽  
Zhenzhong Yong ◽  
...  

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 660
Author(s):  
Marcin H. Kudzin ◽  
Maciej Boguń ◽  
Zdzisława Mrozińska ◽  
Anna Kaczmarek

In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA–ALG–Cu2+) composite fibers and their characterization. The composites were prepared by immersing PLA fibers in aqueous solution of sodium alginate, followed by ionic cross-linking of alginate chains within the polylactide fibers with Cu(II) ions to yield PLA–ALG–Cu2+ composite fibers. The composites, so prepared, were characterized by scanning electron microscopy (SEM), UV/VIS transmittance and attenuated total reflection Fourier-transform infrared spectroscopy ATR-FTIR, and by determination of their specific surface area (SSA), total/average pore volumes (through application of the 5-point Brunauer–Emmett–Teller method (BET)), and ability to block UV radiation (determination of the ultraviolet protection factor (UPF) of samples). The composites were also subjected to in vitro antimicrobial activity evaluation tests against colonies of Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria and antifungal susceptibility tests against Aspergillus niger and Chaetomium globosum fungal mold species. All the results obtained in this work showed that the obtained composites were promising materials to be used as an antimicrobial wound dressing.


2005 ◽  
Vol 889 ◽  
Author(s):  
Bibekananda Sundaray ◽  
V. Subramanian ◽  
T. Srinivasan Natarajan

ABSTRACTElectrospinning is a simple method of obtaining polymer fibers with nanometer diameter. The increase in the ratio of surface area to volume in the case of such fibers, make them attractive in applications such as sensors, etc. It is difficult to electrospin Polypyrrole (PPy) directly to form fibers. Hence electrospinning is attempted with a composite formed with PPy and any other insulating polymer such as Polyethylene oxide (PEO), Polystyrene (PS), etc. The concentration of PPy can be varied to improve the electrical or sensing properties of the resulting composite. In the present report, the PEO-PPy composite fibers with different weight percentages (10% to 50% w/w) are prepared by electrospinning process. The fibers obtained are characterized using SEM (Scanning Electron Microscope) and TEM (Transmission Electron Microscopy). I-V Characteristics are studied for single and multiple aligned fibers obtained on gold electrodes. The variation of electrical conductivity with different concentration of PPy is discussed.


Carbon ◽  
2017 ◽  
Vol 123 ◽  
pp. 593-604 ◽  
Author(s):  
Baoshuai Han ◽  
Enyu Guo ◽  
Xiang Xue ◽  
Zhiyong Zhao ◽  
Liangshun Luo ◽  
...  

2021 ◽  
pp. 66-70
Author(s):  
Zagurskaya M.S. ◽  

Purpose: to substantiate the choice of an antibacterial agent when using the puncture method for the treatment of chronic sinusitis in HIV-infected patients. Material. Microbiological studies were carried out in 108 HIV-infected patients with chronic sinusitis. The microbiological spectrum of pathogens of chronic inflammation of the paranasal sinuses in HIV-infected persons was determined, as well as the sensitivity of microorganisms to antibacterial agents. Results. The most frequently detected microorganisms in HIV-infected patients with chronic inflammatory pathology of the paranasal sinuses are gram-positive cocci (89,7 ± 2,9), including staphylococci (75,7 ± 4,1) and streptococci (14,0 ± 3,3). The verified microflora showed low sensitivity to antibiotics of the penicillin group (less than 65 % of sensitive strains), which limits the possibility of their use. A method for the treatment of chronic sinusitis in HIV-infected patients has been developed, based on the introduction into the sinus of an etiologically substantiated drug with a prolonged action. Conclusion. The revealed features of the spectrum of pathogens and the sensitivity of microorganisms in chronic sinusitis in HIV-infected patients made it possible to scientifically substantiate and develop a treatment method based on the introduction of a polyethylene oxide-based ointment containing chloramphenicol and methyluracil into the sinus.


Author(s):  
G. G. Cocks ◽  
C. E. Cluthe

The freeze etching technique is potentially useful for examining dilute solutions or suspensions of macromolecular materials. Quick freezing of aqueous solutions in Freon or propane at or near liquid nitrogen temperature produces relatively large ice crystals and these crystals may damage the structures to be examined. Cryoprotective agents may reduce damage to the specimem, hut their use often results in the formation of a different set of specimem artifacts.In a study of the structure of polyethylene oxide gels glycerol and sucrose were used as cryoprotective agents. The experiments reported here show some of the structures which can appear when these cryoprotective agents are used.Figure 1 shows a fractured surface of a frozen 25% aqueous solution of sucrose. The branches of dendritic ice crystals surrounded hy ice-sucrose eutectic can be seen. When this fractured surface is etched the ice in the dendrites sublimes giving the type of structure shown in Figure 2. The ice-sucrose eutectic etches much more slowly. It is the smooth continuous structural constituent surrounding the branches of the dendrites.


Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
AC Valle ◽  
L Rabelo ◽  
AL Magalhães ◽  
M Neves ◽  
I Maciel ◽  
...  

2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>


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