A novel high mechanical and excellent hydrophilic electrospun polyurethane ‐silk‐ bioactive glass nanofiber film for rotator cuff injury repair

2021 ◽  
pp. 51746
Author(s):  
Kaikai Duan ◽  
Ziao Ling ◽  
Minghui Sun ◽  
Weiliang Zhi ◽  
Yifeng Zhang ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Bioactive Glass ◽  
Injury Repair ◽  
Rotator Cuff Injury ◽  
Nanofiber Film

scholarly journals A Dual-Factor Releasing Hydrogel for Rotator Cuff Injury Repair

2021 ◽  
Vol 8 ◽  
Author(s):  
Chong Teng ◽  
Yifei Fang ◽  
Huangrong Zhu ◽  
Leyi Huang ◽  
Yanglei Jin ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Surgical Reconstruction ◽  
Repair Capacity ◽  
Bone Interface ◽  
Injury Repair ◽  
Injured Area ◽  
Rotator Cuff Injury ◽  
Two Factors ◽  
Fast Healing

Rotator cuff injury causes pain in the shoulder and is a challenge to be repaired even after surgical reconstruction. Here, we developed a dual-factor releasing hydrogel based on sulfhydrylated chitosan to deliver KGN and FGF-2 to the injured area to enable fast healing of the tendon–bone interface, which is essential for the repair of rotator cuff injury. We found that the two factors could be easily loaded into the hydrogel, which could in turn continuously release the factors in physiological conditions. The hydrogel was found to be a porous structure through a scanning electron microscope (SEM). The micropores in the hydrogel structure enable the loading and releasing of these molecules. This study showed that KGN and FGF-2 could play a synergistic effect by recruiting and promoting stem cell proliferation and chondrogenesis, thus accelerating the healing of the tendon–bone interface. An in vivo study based on a rabbit rotator cuff injury model demonstrated that the dual-factor releasing hydrogel possesses superior repair capacity than a single-factor releasing hydrogel and the untreated groups. In conclusion, the KGN and FGF-2 dual-factor releasing hydrogel could be a promising biomaterial for the regeneration of the tendon–bone interface and rotator cuff injury repair.

Biomimetic Nanofiber Scaffolds for Tendon-to-Bone Insertion Repair

2014 ◽  
Vol 875-877 ◽  
pp. 331-334 ◽  
Author(s):  
Jing Wei Xie ◽  
Bing Ma ◽  
Franklin D. Shuler
Keyword(s):  
Rotator Cuff ◽  
Fiber Orientation ◽  
Mineral Content ◽  
Collagen Fiber ◽  
Insertion Site ◽  
Injury Repair ◽  
Nanofiber Scaffolds ◽  
Rotator Cuff Injury ◽  
Fiber Organization

This paper reports the fabrication of nanofiber scaffolds with dual gradients in both mineral content and fiber orientation, which can be used to mimic the composition and collagen fiber organization at native tendon-to-bone insertion site. Such scaffolds show great potential for rotator cuff injury repair.

scholarly journals Patient-led use of patient-reported outcome measure in self-Management of a Rotator Cuff Injury

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Maria J. Santana ◽  
Darrell J. Tomkins
Keyword(s):  
Rotator Cuff ◽  
Healthcare Providers ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Self Management ◽  
Care Organization ◽  
Surgical Interventions ◽  
Patient Reported ◽  
Rotator Cuff Injury ◽  
Dash Questionnaire

Abstract Introduction The patient is the person who experiences both the processes and the outcomes of care. Information held by the patient is vital for clinical and self-management, improving health outcomes, delivery of care, organization of health systems, and formulation of health policies. Patient-reported outcome measures (PROMs) play an important role in supporting patient’s self-management. This narrative describes a patient-led use of a PROM to self-manage after a rotator cuff injury. Methods This is a narrative of a patient who tore the supraspinatus tendon in her right shoulder in an accident. The Disabilities of the Arm, Shoulder and Hand, the DASH questionnaire, was used to monitor and self-manage recovery after the accident. The DASH questionnaire is a self-reported questionnaire that measures the difficulty in performing upper extremity activities and pain in the arm, shoulder or hand. It has been widely used in research studies, but here the patient initiated its use for self-management while waiting for and after rotator cuff surgery. The patient created separate sub-scale scores for function and for pain to answer questions from healthcare providers about her recovery. Results There was noticeable improvement over 3 months of conservative treatment, from a high level of disability of 56 to 39 (score changed 17); however, the scores were nowhere near the general population normative score of 10.1. Surgery improved the score from 39 pre-surgery to 28. Post-surgical interventions included physiotherapy, pain management and platelet-riched plasma treatment (PRP). The score was 14 4 weeks post-PRP. Conclusions The patient found the DASH useful in monitoring recovery from a rotator cuff injury (before and after surgery). The DASH contributed to communication with healthcare professionals and supported the clinical management. The DASH questionnaire was able to capture the patient’s experience with the injury and surgical recovery, corroborating an improvement in function while there was persistent post-surgical pain.

scholarly journals Efficacy of hyaluronic acid or steroid injections for the treatment of a rat model of rotator cuff injury

2015 ◽  
Vol 33 (12) ◽  
pp. 1861-1867 ◽  
Author(s):  
Takeshi Yamaguchi ◽  
Nobuyasu Ochiai ◽  
Yu Sasaki ◽  
Takehiro Kijima ◽  
Eiko Hashimoto ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Rotator Cuff ◽  
Rat Model ◽  
Steroid Injections ◽  
Rotator Cuff Injury

scholarly journals Mechanical stimulation promotes enthesis injury repair by mobilizing Prx1+ cells via ciliary TGF-β signaling

2021 ◽  
Author(s):  
Han Xiao ◽  
Tao Zhang ◽  
Chang Jun Li ◽  
Yong Cao ◽  
Lin Feng Wang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Rotator Cuff ◽  
Single Cell ◽  
Mechanical Stimulation ◽  
Essential Role ◽  
Primary Cilia ◽  
Underlying Mechanism ◽  
Rna Sequence ◽  
Injury Repair ◽  
Tgf Β1

Proper mechanical stimulation can improve rotator cuff enthsis injury repair. However, the underlying mechanism of mechanical stimulation promoting injury repair is still unknown. In this study, we found that Prx1+ cell was essential for murine rotator cuff enthesis development identified by single-cell RNA sequence and involved in the injury repair. Proper mechanical stimulation could promote the migration of Prx1+ cells to enhance enthesis injury repair. Meantime, TGF-β signaling and primary cilia played an essential role in mediating mechanical stimulation signaling transmission. Proper mechanical stimulation enhanced the release of active TGF-β1 to promote migration of Prx1+ cells. Inhibition of TGF-β signaling eliminated the stimulatory effect of mechanical stimulation on Prx1+ cell migration and enthesis injury repair. In addition, knockdown of Pallidin to inhibit TGF-βR2 translocation to the primary cilia or deletion of IFT88 in Prx1+ cells also restrained the mechanics-induced Prx1+ cells migration. These findings suggested that mechanical stimulation could increase the release of active TGF-β1 and enhance the mobilization of Prx1+ cells to promote enthesis injury repair via ciliary TGF-β signaling.

scholarly journals Repair of Lafosse I subscapularis injury adds no additional value in anterosuperior rotator cuff injury

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Binghao Zhao ◽  
Qingsong Zhang ◽  
Bo Liu
Keyword(s):  
Rotator Cuff ◽  
Range Of Motion ◽  
Shoulder Joint ◽  
Statistical Difference ◽  
Supraspinatus Tendon ◽  
Joint Function ◽  
Tendon Tear ◽  
Rotator Cuff Injury ◽  
Additional Value ◽  
Repair Group

Abstract Background The study aimed to explore the additional value of repair of Lafosse I subscapularis injury compared with debridement in anterosuperior rotator cuff injury. Methods The prospective study was conducted on a total of 41 patients with supraspinatus tendon tear combined with Lafosse I subscapularis injury. Eighteen patients were divided into the repair group and 23 patients were divided into the non-repair group. The two groups were compared for intraoperative parameters, pain score, range of motion of the shoulder joint, shoulder joint function and quality of life (QoL) at pre-operation, 3 and 6 months postoperatively and the final follow-up visit. Results The width of supraspinatus tendon tear did not exceed 3 cm and did not retract beyond the glenoid in among patients. There was no statistical difference of preoperative data between two groups, including age, course of disease, positive Jobe test, positive Bear-hug test, positive Lift-off test, Patte stage, longitudinal tear and pain severity (P > 0.05). Compared to preoperative levels, the severity of pain, ASES scores and EQ-5D-3L scores were significantly lower at 3 and 6 months postoperatively and the final position (P < 0.05). However, there was no statistical difference in pain severity, ASES scores and EQ-5D-3L scores between repair group and non-repair group (P > 0.05). Similarly, compared to preoperative levels, the range of motion of shoulder joint was significantly improved after operation, including internal rotation, external rotation, forward flexion and elevation (P < 0.05). However, there was no statistical difference in range of motion of shoulder joint between repair group and non-repair group (P > 0.05). Conclusion Operative treatment can effectively lessen severity of pain in the patients, improve shoulder joint function, increase the range of motion of the shoulder joint and enhance the QoL in treating anterosuperior rotator cuff injury. However, repair of subscapularis brings no benefit compared to debridement in treating supraspinatus tendon tear combined with Lafosse I subscapularis injury.

scholarly journals Use of Radiographic Criteria for Proximal Humeral Head Migration After Dislocation of the Shoulder to Identify Damage to Its Rotator Cuff

2019 ◽  
Vol 100 (2) ◽  
pp. 95-101
Author(s):  
A. P. Stepanchenko ◽  
G. V. Fedoruk ◽  
A. A. Makovskiy ◽  
V. E. Dubrov ◽  
R. V. Zaytsev ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Correlation Analysis ◽  
Humeral Head ◽  
Shoulder Dislocation ◽  
Older Patients ◽  
Subacromial Space ◽  
Rotator Cuff Injury ◽  
Mri Study ◽  
Mri Measurements

Objective. To assess whether radiographic criteria for proximal humeral head migration can be used as screening of damage to the rotator cuff after dislocation in patients over 45 years of age.Material and methods. The study included the results of a follow-up of 101 patients after shoulder dislocation without signs of damage to the rotator cuff before injury. Damage to the rotator cuff was assessed using MRI, followed by a correlation analysis between the results of measuring the height of the subacromial space with radiography and MRI.Results. Signs of cranial migration of the humeral head are detected statistically significantly more frequently in the group of older patients than in that of young ones (F=0.009; p<0.05). MRI study statistically significantly more often revealed signs of damage to the rotator cuff in the older patients than in the young ones (F=0.009; p<0.05). There was a high correlation between the humeral head migration index and the MRI measurements of the acromiohumeral interval (r=0.93, p<0.05).Conclusion. The acromiohumeral index, as well as MRI, can be used as a criterion for rotator cuff injury. This study has shown that the older patients have a 19-fold higher risk for damage to the rotator cuff from a dislocated shoulder (95% CI 6.93–52.11). Thus, attention should be paid to the presence of radiographic signs of rotator cuff injury in all patients after dislocation of the shoulder.

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