scholarly journals Efficacy of hyaluronic acid or steroid injections for the treatment of a rat model of rotator cuff injury

2015 ◽  
Vol 33 (12) ◽  
pp. 1861-1867 ◽  
Author(s):  
Takeshi Yamaguchi ◽  
Nobuyasu Ochiai ◽  
Yu Sasaki ◽  
Takehiro Kijima ◽  
Eiko Hashimoto ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Rotator Cuff ◽  
Rat Model ◽  
Steroid Injections ◽  
Rotator Cuff Injury

Healing Effect of Subcutaneous Administration of G-CSF on Acute Rotator Cuff Injury in a Rat Model

2021 ◽  
Author(s):  
Yusuke Kobayashi ◽  
Yoshikazu Kida ◽  
Yukichi Kabuto ◽  
Toru Morihara ◽  
Tsuyoshi Sukenari ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rat Model ◽  
Subcutaneous Administration ◽  
Healing Effect ◽  
Rotator Cuff Injury

scholarly journals Architectural and Biochemical Adaptations in Skeletal Muscle and Bone Following Rotator Cuff Injury in a Rat Model

2015 ◽  
Vol 97 (7) ◽  
pp. 565-573 ◽  
Author(s):  
Eugene J Sato ◽  
Megan L Killian ◽  
Anthony J Choi ◽  
Evie Lin ◽  
Alexander D Choo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Rotator Cuff ◽  
Rat Model ◽  
Rotator Cuff Injury

scholarly journals Transient decreases in forelimb gait and ground reaction forces following rotator cuff injury and repair in a rat model

2010 ◽  
Vol 43 (4) ◽  
pp. 778-782 ◽  
Author(s):  
Joseph J. Sarver ◽  
Michael I. Dishowitz ◽  
Soung-Yon Kim ◽  
Louis J. Soslowsky
Keyword(s):  
Rotator Cuff ◽  
Rat Model ◽  
Ground Reaction Forces ◽  
Rotator Cuff Injury ◽  
Reaction Forces ◽  
Injury And Repair

Inhibition of Smad3 promotes the healing of rotator cuff injury in a rat model

2020 ◽  
Vol 39 (1) ◽  
pp. 204-218
Author(s):  
Yi Wang ◽  
Zhiyou Zhou ◽  
Yang Liu ◽  
Zimin Wang ◽  
Yifan Kang
Keyword(s):  
Rotator Cuff ◽  
Rat Model ◽  
Rotator Cuff Injury

Biceps Detachment Preserves Joint Function in a Chronic Massive Rotator Cuff Tear Rat Model: Response

2019 ◽  
Vol 47 (5) ◽  
pp. NP34-NP35
Author(s):  
Mengcun Chen ◽  
Snehal S. Shetye ◽  
Julianne Huegel ◽  
Corinne N. Riggin ◽  
Daniel J. Gittings ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Rat Model ◽  
Joint Function ◽  
Massive Rotator Cuff Tear ◽  
Cuff Tear ◽  
Model Response

Effect of a Porous Suture Containing Transforming Growth Factor Beta 1 on Healing After Rotator Cuff Repair in a Rat Model

2021 ◽  
pp. 036354652110285
Author(s):  
Jong Pil Yoon ◽  
Hun-Min Kim ◽  
Jin-Hyun Choi ◽  
Hae Rim Kang ◽  
Dong Hyun Kim ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rat Model ◽  
Transforming Growth Factor Beta ◽  
Rotator Cuff Repair ◽  
Animal Experiment ◽  
Transforming Growth Factor ◽  
Group 3 ◽  
Growth Factor Beta ◽  
Cuff Repair ◽  
Tgf Β1

Background: The healing failure rate after rotator cuff repair is considerably high. Purpose: To evaluate the effect of a porous suture containing transforming growth factor beta 1 (TGF-β1) on the sustained release of TGF-β1 and rotator cuff healing in a rat model. Study Design: Controlled laboratory study. Methods: A porous suture was developed, and its tensile strength was measured. TGF-β1 was delivered using the porous suture, and a TGF-β1 release test and human fibroblast proliferation assay were performed. For the animal experiment, 30 rats were randomly allocated into 3 groups (n = 10 each). A bilateral supraspinatus tendon tear was made in all the rats, and repair was performed. Group 1 received repair only; group 2, repair and a single injection of TGF-β1; and group 3, repair using the porous suture containing TGF-β1. Eight weeks after repair, biomechanical and histological analyses were performed. Results: The porous suture was successfully developed with mechanical properties compatible with the conventional suture, and the sustained release of TGF-β1 from the porous suture was confirmed. In addition, the cell proliferation assay confirmed the biological safety of the porous suture. In the animal experiment, group 3 biomechanically exhibited the largest cross-sectional area and the highest ultimate failure load and ultimate stress (all P < .05). Histological examination revealed that group 3 showed significantly better collagen fiber density and tendon-to-bone maturation than did groups 1 and 2 (all P < .05). Conclusion: The porous suture containing TGF-β1 could sustainedly and safely release TGF-β1, and its use during rotator cuff repair could improve rotator cuff healing, as assessed on the basis of the biomechanical and histological changes in the rat model in this study. Considering the effectiveness, safety, and convenience of the porous suture without extra effort in surgery, the findings of the present study will have a far-reaching effect on the treatment of rotator cuff tears. Clinical Relevance: The porous suture containing TGF-β1 might improve healing after rotator cuff repair.

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