La 3+ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

2021 ◽  
pp. 50978
Author(s):  
Chenyang Zhang ◽  
Hailin Wu ◽  
Jing Chen ◽  
Peizhi Zhu ◽  
Chunxia Gao
Keyword(s):  
Glutamic Acid ◽  
High Strength ◽  
Cartilage Regeneration ◽  
Swelling Property

scholarly journals Digital Light Processing Bioprinted Human Chondrocyte-Laden Poly (γ-Glutamic Acid)/Hyaluronic Acid Bio-Ink towards Cartilage Tissue Engineering

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 714
Author(s):  
Alvin Kai-Xing Lee ◽  
Yen-Hong Lin ◽  
Chun-Hao Tsai ◽  
Wan-Ting Chang ◽  
Tsung-Li Lin ◽  
...  
Keyword(s):  
United States ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Glutamic Acid ◽  
Cellular Proliferation ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
The United States ◽  
Cartilage Injury ◽  
Cartilage Tissue

Cartilage injury is the main cause of disability in the United States, and it has been projected that cartilage injury caused by osteoarthritis will affect 30% of the entire United States population by the year 2030. In this study, we modified hyaluronic acid (HA) with γ-poly(glutamic) acid (γ-PGA), both of which are common biomaterials used in cartilage engineering, in an attempt to evaluate them for their potential in promoting cartilage regeneration. As seen from the results, γ-PGA-GMA and HA, with glycidyl methacrylate (GMA) as the photo-crosslinker, could be successfully fabricated while retaining the structural characteristics of γ-PGA and HA. In addition, the storage moduli and loss moduli of the hydrogels were consistent throughout the curing durations. However, it was noted that the modification enhanced the mechanical properties, the swelling equilibrium rate, and cellular proliferation, and significantly improved secretion of cartilage regeneration-related proteins such as glycosaminoglycan (GAG) and type II collagen (Col II). The cartilage tissue proof with Alcian blue further demonstrated that the modification of γ-PGA with HA exhibited suitability for cartilage tissue regeneration and displayed potential for future cartilage tissue engineering applications. This study built on the previous works involving HA and further showed that there are unlimited ways to modify various biomaterials in order to further bring cartilage tissue engineering to the next level.

Biodegradable High-Strength Hydrogels with Injectable Performance Based on Poly(l-Glutamic Acid) and Gellan Gum

2020 ◽  
Vol 6 (8) ◽  
pp. 4702-4713 ◽  
Author(s):  
Hongjie Zong ◽  
Bo Wang ◽  
Guifei Li ◽  
Shifeng Yan ◽  
Kunxi Zhang ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
High Strength ◽  
Gellan Gum

Boron-assisted dual-crosslinked poly (γ-glutamic acid) hydrogels with high toughness for cartilage regeneration

2020 ◽  
Vol 153 ◽  
pp. 158-168 ◽  
Author(s):  
Shuai Liu ◽  
Yajie Pu ◽  
Rong Yang ◽  
Xin Liu ◽  
Penghui Wang ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Cartilage Regeneration ◽  
High Toughness

scholarly journals Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Materials ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 235
Author(s):  
Hua Lin ◽  
Cuilan Yin ◽  
Anchun Mo ◽  
Guang Hong
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Cartilage Tissue Engineering ◽  
Antibacterial Properties ◽  
High Strength ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Medical Progress ◽  
Extracellular Matrix Components ◽  
And Cartilage

Hydrogel is a polymer matrix containing a large amount of water. It is similar to extracellular matrix components. It comes into contact with blood, body fluids, and human tissues without affecting the metabolism of organisms. It can be applied to bone and cartilage tissues. This article introduces the high-strength polymer hydrogel and its modification methods to adapt to the field of bone and cartilage tissue engineering. From the perspective of the mechanical properties of hydrogels, the mechanical strength of hydrogels has experienced from the weak-strength traditional hydrogels to the high-strength hydrogels, then the injectable hydrogels were invented and realized the purpose of good fluidity before the use of hydrogels and high strength in the later period. In addition, specific methods to give special physical properties to the hydrogel used in the field of bone and cartilage tissue engineering will also be discussed, such as 3D printing, integrated repair of bone and cartilage tissue, bone vascularization, and osteogenesis hydrogels that regulate cell growth, antibacterial properties, and repeatable viscosity in humid environments. Finally, we explain the main reasons and contradictions in current applications, look forward to the research prospects in the field of bone and cartilage tissue engineering, and emphasize the importance of conducting research in this field to promote medical progress.

Poly(l-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration

2014 ◽  
Vol 10 (1) ◽  
pp. 276-288 ◽  
Author(s):  
Jianjun Fang ◽  
Yun Zhang ◽  
Shifeng Yan ◽  
Zhiwen Liu ◽  
Shiming He ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Polyelectrolyte Complex ◽  
Cartilage Regeneration ◽  
Porous Microspheres

Decomposition of the metastable beta titanium alloy Ti-15-3

1983 ◽  
Vol 41 ◽  
pp. 264-265
Author(s):  
Y. L. Chen ◽  
S. Fujlshiro
Keyword(s):  
Low Cost ◽  
High Strength ◽  
Alpha Phase ◽  
Thick Sheet ◽  
Omega Phase ◽  
Beta Titanium Alloy ◽  
Beta Titanium ◽  
Beta Matrix ◽  
Metastable Beta ◽  
Very High

Metastable beta titanium alloys have been known to have numerous advantages such as cold formability, high strength, good fracture resistance, deep hardenability, and cost effectiveness. Very high strength is obtainable by precipitation of the hexagonal alpha phase in a bcc beta matrix in these alloys. Precipitation hardening in the metastable beta alloys may also result from the formation of transition phases such as omega phase. Ti-15-3 (Ti-15V- 3Cr-3Al-3Sn) has been developed recently by TIMET and USAF for low cost sheet metal applications. The purpose of the present study was to examine the aging characteristics in this alloy.The composition of the as-received material is: 14.7 V, 3.14 Cr, 3.05 Al, 2.26 Sn, and 0.145 Fe. The beta transus temperature as determined by optical metallographic method was about 770°C. Specimen coupons were prepared from a mill-annealed 1.2 mm thick sheet, and solution treated at 827°C for 2 hr in argon, then water quenched. Aging was also done in argon at temperatures ranging from 316 to 616°C for various times.

Effects of cooling rate on the mechanical properties of dual phase treated vanadium steels

1983 ◽  
Vol 41 ◽  
pp. 220-221
Author(s):  
L.J. Chen ◽  
H.C. Cheng ◽  
J.R. Gong ◽  
J.G. Yang
Keyword(s):  
Mechanical Properties ◽  
Cooling Rate ◽  
Automobile Industry ◽  
High Strength ◽  
Weight Percent ◽  
Low Alloy Steels ◽  
Dual Phase ◽  
Resource Requirement ◽  
Alloy Steels ◽  
Potential Weight

For fuel savings as well as energy and resource requirement, high strength low alloy steels (HSLA) are of particular interest to automobile industry because of the potential weight reduction which can be achieved by using thinner section of these steels to carry the same load and thus to improve the fuel mileage. Dual phase treatment has been utilized to obtain superior strength and ductility combinations compared to the HSLA of identical composition. Recently, cooling rate following heat treatment was found to be important to the tensile properties of the dual phase steels. In this paper, we report the results of the investigation of cooling rate on the microstructures and mechanical properties of several vanadium HSLA steels.The steels with composition (in weight percent) listed below were supplied by China Steel Corporation: 1. low V steel (0.11C, 0.65Si, 1.63Mn, 0.015P, 0.008S, 0.084Aℓ, 0.004V), 2. 0.059V steel (0.13C, 0.62S1, 1.59Mn, 0.012P, 0.008S, 0.065Aℓ, 0.059V), 3. 0.10V steel (0.11C, 0.58Si, 1.58Mn, 0.017P, 0.008S, 0.068Aℓ, 0.10V).

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