Bovine serum albumin gel/polyelectrolyte complex of hyaluronic acid and chitosan based microcarriers for Sorafenib targeted delivery

2020 ◽  
Vol 137 (34) ◽  
pp. 49002 ◽  
Author(s):  
Violeta Paşcalău ◽  
Mihaela Tertis ◽  
Emoke Pall ◽  
Maria Suciu ◽  
Traian Marinca ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Targeted Delivery ◽  
Bovine Serum ◽  
Polyelectrolyte Complex

Kinetics and Efficiency of a Methyl-Carboxylated 5-Fluorouracil-Bovine Serum Albumin Adduct for Targeted Delivery

2013 ◽  
Vol 14 (3) ◽  
pp. 428-439 ◽  
Author(s):  
Michael J. Koziol ◽  
Torsten K. Sievers ◽  
Kathrin Smuda ◽  
Yu Xiong ◽  
Angelika Müller ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Targeted Delivery ◽  
Bovine Serum

scholarly journals A PREFORMULATION STUDY ON INTERACTIONS BETWEEN DOXORUBICIN HYDROCHLORIDE AND BOVINE SERUM ALBUMIN

2017 ◽  
Vol 9 (6) ◽  
pp. 95
Author(s):  
K. C. Ajithkumar ◽  
K. Pramod
Keyword(s):  
Refractive Index ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Fluorescence Intensity ◽  
Targeted Delivery ◽  
Bovine Serum ◽  
Optical Rotation ◽  
Uv Absorbance ◽  
Doxorubicin Hydrochloride ◽  
Wide Range

Objective: The objective was to study the effect of concentrations of doxorubicin hydrochloride (Dox) and bovine serum albumin (BSA) in a sample on fluorescence intensity, UV absorbance, refractive index and optical rotation.Methods: A circumscribed central composite statistical design with 2 factors, 5 levels, and 13 runs was selected for the study. According to that influence of both in interaction was measured by fluorescence intensity, UV absorbance, refractive index and optical rotation and were analyzed by the design expert software.Results: It was observed that concentration of BSA alone was significantly affecting the fluorescence intensity and optical rotation of samples. Dox alone was having a significant effect on UV absorbance at 280 nm. In the case of a refractive index, both Dox and BSA were having a significant effect. But the effect of BSA was much pronounced than that of Dox on refractive index.Conclusion: Interaction studies between BSA and Dox would be beneficial as they are commonly used in combination with tumor-targeted delivery. The interaction was observed that in a linear model for a wide range of concentration of both. So it will be useful to determine the interaction of unknown concentration.

Further evidence for hyaluronidase activity of Treponema pallidum

1983 ◽  
Vol 29 (11) ◽  
pp. 1507-1513 ◽  
Author(s):  
T. J. Fitzgerald ◽  
E. M. Gannon
Keyword(s):  
Enzyme Activity ◽  
Hyaluronic Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Capillary Permeability ◽  
Treponema Pallidum ◽  
Intradermal Injection ◽  
Hyaluronidase Activity ◽  
Immunologic Reactions

The presence of hyaluronidase in preparations of Treponema pallidum was previously shown using acidified bovine serum albumin reactions and Ouchterlony immunodiffusion. To expand on these preliminary findings more sensitive techniques of viscometry, additional immunologic reactions, and altered capillary permeability were used to characterize treponemal-associated hyaluronidase. The pathogens T. pallidum and T. pertenue degraded hyaluronic acid, whereas the nonpathogens T. denticola and T. vincentii did not. As syphilitic infection progressed, hyaluronidase activity decreased; organisms harvested from 14-day testicular infections degraded hyaluronic acid less rapidly than organisms from 4-day infections. Uninfected rabbit testicular extract also exhibited significant enzyme activity. The neutralizing activity of immune sera was decreased by prior adsorption with bovine hyaluronidase, suggesting that some of the neutralizing factors are associated with this enzyme. Radioimmunoassay was used to quantitate antibodies to hyaluronidase in immune sera. Antihyaluronidase sera were isolated from rabbits immunized with bovine hyaluronidase. Treponema pallidum, as well as uninfected rabbit testicular extract, cross-reacted with these antisera. Immunofluorescence indicated that the hyaluronidase was uniformly distributed along the treponemal surface. As a final indicator of hyaluronidase activity, alterations in capillary permeability were detected 1 h after intradermal injection of T. pallidum.

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