Mannose 6-phosphate-modified bovine serum albumin nanoparticles for controlled and targeted delivery of sodium ferulate for treatment of hepatic fibrosis

2009 ◽  
Vol 61 (9) ◽  
pp. 1155-1161 ◽  
Author(s):  
Feng-Qian Li ◽  
Hua Su ◽  
Xu Chen ◽  
Xian-Ju Qin ◽  
Ji-Yong Liu ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Hepatic Fibrosis ◽  
Targeted Delivery ◽  
Bovine Serum ◽  
Sodium Ferulate ◽  
Albumin Nanoparticles ◽  
Mannose 6 Phosphate

Preparation and characterization of sodium ferulate entrapped bovine serum albumin nanoparticles for liver targeting

2008 ◽  
Vol 349 (1-2) ◽  
pp. 274-282 ◽  
Author(s):  
Feng-Qian Li ◽  
Hua Su ◽  
Jing Wang ◽  
Ji-Yong Liu ◽  
Quan-Gang Zhu ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Liver Targeting ◽  
Sodium Ferulate ◽  
Albumin Nanoparticles

Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin

2013 ◽  
Vol 448 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Caiyun Li ◽  
Dianrui Zhang ◽  
Hejian Guo ◽  
Leilei Hao ◽  
Dandan Zheng ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Targeted Delivery ◽  
Bovine Serum ◽  
Albumin Nanoparticles

Cholesterol‐conjugated bovine serum albumin nanoparticles as a tamoxifen tumor‐targeted delivery system

2020 ◽  
Vol 44 (12) ◽  
pp. 2485-2498
Author(s):  
Mahmoud Gharbavi ◽  
Behrooz Johari ◽  
Seyed Sadegh Eslami ◽  
Navid Mousazadeh ◽  
Ali Sharafi
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Delivery System ◽  
Targeted Delivery ◽  
Bovine Serum ◽  
Albumin Nanoparticles ◽  
Targeted Delivery System

Transfecting pDNA to E . coli DH5α using bovine serum albumin nanoparticles as a delivery vehicle

Luminescence ◽  
2014 ◽  
Vol 30 (5) ◽  
pp. 583-591 ◽  
Author(s):  
Jitendra Wagh ◽  
Kuldeep J. Patel ◽  
Parth Soni ◽  
Krutika Desai ◽  
Pratik Upadhyay ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Delivery Vehicle ◽  
E Coli ◽  
Albumin Nanoparticles

Quality by Design Approach for Development and Optimization of Rifampicin Loaded Bovine Serum Albumin Nanoparticles and Characterization

2021 ◽  
Vol 18 ◽  
Author(s):  
Monica Joshi ◽  
Khushwant S. Yadav ◽  
Bala Prabhakar
Keyword(s):  
Particle Size ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Quality By Design ◽  
Entrapment Efficiency ◽  
Quality Attributes ◽  
Albumin Nanoparticles ◽  
Therapeutic Benefits ◽  
Intravenous Application

Background: Rifampicin is one of the first line drugs used for tuberculosis therapy. The therapy lasts for a long time. Thus, there is a need to develop sustained release formulation of rifampicin for intravenous application. Aim: This study is focused on preparing rifampicin loaded bovine serum albumin nanoparticles (RIF BSA NPs) suitable for intravenous application using systematic quality by design (QbD) approach. Objectives: The main objective of this study is optimizing particle size and entrapment efficiency of rifampicin loaded bovine serum albumin nanoparticles (RIF BSA NPs) and making it suitable for intravenous application using QbD approach. Methods: Quality target product profile was defined along with critical quality attributes (CQAs) for the formulation. 32 factorial design was used for achieving the predetermined values of CQAs, i.e., mean particle size <200 nm and percent entrapment efficiency>50%. Incubation time of drug with colloidal albumin solution and ratio of rifampicin: albumin, were selected as independent variables. Check point analysis was performed to confirm the suitability of regression model for optimization. Results: : The optimized RIF BSA NPs were characterized by FTIR, DSC, 1H NMR techniques. The NPs observed by transmission electron microscopy were spherical in shape. The rifampicin release could be sustained for 72 hours from BSA NPs matrix. RIF BSA NPs dispersion was stable at 5 ± 3°C for 72 hours. Non-toxicity of nanoparticles to RAW 264.7 cell line was proved by MTT assay. Conclusion: Development of RIF BSA NPs with desired quality attributes was possible by implementing QbD approach. The optimized formulation suitable for intravenous application can potentially improve the therapeutic benefits of rifampicin.

scholarly journals Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Haipeng Wang ◽  
Shuilin Sun ◽  
Yu Zhang ◽  
Jiayi Wang ◽  
Shouhua Zhang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Liver Tumor ◽  
Bovine Serum ◽  
Drug Targeting ◽  
Albumin Nanoparticles
Sign in / Sign up

Export Citation Format

Share Document