Ginsenoside Rg1‐modified PHBV fibrous scaffold reduces interleukin‐1 beta‐induced dedifferentiation of articular chondrocytes

2019 ◽  
Vol 137 (7) ◽  
pp. 48378
Author(s):  
Yongsheng Li ◽  
Risheng Zhong ◽  
Zheng Zhou ◽  
Hairong Liu ◽  
Yao Dai ◽  
...  
Keyword(s):  
Articular Chondrocytes ◽  
Interleukin 1 ◽  
Ginsenoside Rg1 ◽  
Interleukin 1 Beta ◽  
Fibrous Scaffold

scholarly journals Induction of Osteogenic Protein-1 Expression by Interleukin-1.BETA. in Cultured Rabbit Articular Chondrocytes.

2002 ◽  
Vol 197 (2) ◽  
pp. 101-109 ◽  
Author(s):  
SATOSHI YOSHIDA ◽  
YOSHIKO KUBOTA ◽  
TAMOTSU TOBA ◽  
SABURO HORIUCHI ◽  
TADASHI SHIMAMURA
Keyword(s):  
Articular Chondrocytes ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Osteogenic Protein ◽  
Rabbit Articular Chondrocytes

scholarly journals Effect ofAngelica sinensisPolysaccharides on OsteoarthritisIn VivoandIn Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Jun Qin ◽  
Yan-song Liu ◽  
Jun Liu ◽  
Jing Li ◽  
Yang Tan ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Articular Chondrocytes ◽  
Interleukin 1 ◽  
Knee Joints ◽  
Protective Effects ◽  
Interleukin 1 Beta ◽  
Degrading Enzymes ◽  
Matrix Degrading Enzymes

This study investigated the effect ofAngelica sinensispolysaccharides (APS-3c) on rat osteoarthritis (OA) modelin vivoand rat interleukin-1-beta- (IL-1β-) stimulated chondrocytesin vitro. APS-3c was administrated into rat OA knee joints and had protective effects on rat OA cartilagein vivo. Primary rat articular chondrocytes were cotreated with APS-3c and IL-1β  in vitro. 2~50 μg/mL APS-3c had no effect on chondrocytes viability, whereas it increased the proteoglycans (PGs) synthesis inhibited by IL-1β. Microarray analysis showed that the significant changes were concentrated in the genes which were involved in PGs synthesis. RT-PCR confirmed that treatment with APS-3c increased the mRNA expression of aggrecan and glycosyltransferases (GTs) inhibited by IL-1βbut did not affect the mRNA expression of matrix-degrading enzymes. These results indicate that APS-3c can improve PGs synthesis of chondrocytes on rat OA modelin vivoand IL-1β-stimulated chondrocytesin vitro, which is due to the promotion of the expression of aggrecan and GTs involved in PGs synthesis but not the inhibition of the expression of matrix-degrading enzymes. Our findings suggest the clinical relevance of APS-3c in the prospective of future alternative medical treatment for OA.

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