In vitro hydrolysis and magnesium release of poly(d,l-lactide-co-glycolide)-based composites containing bioresorbable glasses and magnesium hydroxide

2015 ◽  
Vol 132 (41) ◽  
pp. n/a-n/a ◽  
Author(s):  
Peter Uppstu ◽  
Charlotta Paakki ◽  
Ari Rosling
2004 ◽  
Vol 11 (2) ◽  
pp. 266-271 ◽  
Author(s):  
Guénolée Prioult ◽  
Sophie Pecquet ◽  
Ismail Fliss

ABSTRACT We have previously demonstrated that Lactobacillus paracasei NCC2461 may help to prevent cow's milk allergy in mice by inducing oral tolerance to β-lactoglobulin (BLG). To investigate the mechanisms involved in this beneficial effect, we examined the possibility that L. paracasei induces tolerance by hydrolyzing BLG-derived peptides and liberating peptides that stimulate interleukin-10 (IL-10) production. L. paracasei peptidases have been shown to hydrolyze tryptic-chymotryptic peptides from BLG, releasing numerous small peptides with immunomodulating properties. We have now shown that acidic tryptic-chymotryptic peptides stimulate splenocyte proliferation and gamma interferon (IFN-γ) production in vitro. Hydrolysis of these peptides with L. paracasei peptidases repressed the lymphocyte stimulation, up-regulated IL-10 production, and down-regulated IFN-γ and IL-4 secretion. L. paracasei NCC2461 may therefore induce oral tolerance to BLG in vivo by degrading acidic peptides and releasing immunomodulatory peptides stimulating regulatory T cells, which function as major immunosuppressive agents by secreting IL-10.


2019 ◽  
Vol 59 (5) ◽  
pp. 380-384
Author(s):  
Y. Benaissa ◽  
S. Addou ◽  
W. Dib ◽  
S. Benhatchi ◽  
A. Mehidi ◽  
...  

2020 ◽  
Vol 8 (6) ◽  
pp. 313-313
Author(s):  
Xiujuan Sun ◽  
Aoteng Sun ◽  
Xingya Jia ◽  
Shi Jin ◽  
Dan Zhang ◽  
...  

2017 ◽  
Vol 95 (12) ◽  
pp. 5497-5506 ◽  
Author(s):  
Z. Huang ◽  
P. E. Urriola ◽  
I. J. Salfer ◽  
M. D. Stern ◽  
G. C. Shurson

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