Preparation and aqueous solution behavior of a ph-responsive branched copolymer based on 2-(diethylamino)ethyl methacrylate

2015 ◽  
Vol 132 (29) ◽  
pp. n/a-n/a ◽  
Author(s):  
Lei Wang ◽  
Wen Huang ◽  
Shijie Wang ◽  
Yuezhi Cui ◽  
Pengfei Yang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Ph Responsive ◽  
Solution Behavior ◽  
Ethyl Methacrylate ◽  
Branched Copolymer

Direct synthesis and aqueous solution behavior of pH-responsive, zwitterionic and three-layered branched copolymer nanoparticles

2012 ◽  
Vol 3 (3) ◽  
pp. 625 ◽  
Author(s):  
Erol Hasan ◽  
Steve Furzeland ◽  
Derek Atkins ◽  
Dave J. Adams ◽  
Jonathan V. M. Weaver
Keyword(s):  
Aqueous Solution ◽  
Direct Synthesis ◽  
Ph Responsive ◽  
Solution Behavior ◽  
Branched Copolymer

Effect ofl-Leucine Graft Content on Aqueous Solution Behavior and Membrane-Lytic Activity of a pH-Responsive Pseudopeptide

2009 ◽  
Vol 10 (9) ◽  
pp. 2601-2608 ◽  
Author(s):  
Rongjun Chen ◽  
Sariah Khormaee ◽  
Mark E. Eccleston ◽  
Nigel K. H. Slater
Keyword(s):  
Aqueous Solution ◽  
Lytic Activity ◽  
Ph Responsive ◽  
Solution Behavior

Synthesis, Characterization, and Aqueous Solution Behavior of Electrolyte- and pH-Responsive Carboxybetaine-Containing Cyclocopolymers†

2003 ◽  
Vol 36 (26) ◽  
pp. 9710-9715 ◽  
Author(s):  
David B. Thomas ◽  
Yulia A. Vasilieva ◽  
R. Scott Armentrout ◽  
Charles L. McCormick
Keyword(s):  
Aqueous Solution ◽  
Ph Responsive ◽  
Solution Behavior

Aqueous solution behavior of thermosensitive (N-isopropylacrylamide-acrylic acid-ethyl methacrylate) terpolymers

2004 ◽  
Vol 283 (6) ◽  
pp. 662-670 ◽  
Author(s):  
Marcio Jos� Tiera ◽  
Gerson Rodrigues dos Santos ◽  
Vera A. de Oliveira Tiera ◽  
Neide Aparecida Blaz Vieira ◽  
Elisabete Frolini ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Acrylic Acid ◽  
Solution Behavior ◽  
Ethyl Methacrylate

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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