Evaluation of chitosan and their self-assembled nanoparticles with pDNA for the application in gene therapy

2011 ◽  
Vol 121 (4) ◽  
pp. 2239-2249 ◽  
Author(s):  
Kishor Sarkar ◽  
Rishi Srivastava ◽  
Urmi Chatterji ◽  
P. P. Kundu
Keyword(s):  
Gene Therapy ◽  
Self Assembled

Functional Self-Assembled DNA Nanohydrogels for Specific Telomerase Activity Imaging and Telomerase-Activated Antitumor Gene Therapy

2020 ◽  
Vol 92 (22) ◽  
pp. 15179-15186
Author(s):  
Yuhong Lin ◽  
Yuqing Huang ◽  
Yuling Yang ◽  
Lili Jiang ◽  
Chao Xing ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Telomerase Activity ◽  
Self Assembled

scholarly journals Self-Assembled Aptamer-Nanomedicine for Targeted Chemotherapy and Gene Therapy

Small ◽  
2017 ◽  
Vol 14 (4) ◽  
pp. 1702103 ◽  
Author(s):  
Nianxi Zhao ◽  
Zihua Zeng ◽  
Youli Zu
Keyword(s):  
Gene Therapy ◽  
Targeted Chemotherapy ◽  
Self Assembled

A self-assembled DNA-nanoparticle with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke

2019 ◽  
Vol 7 (5) ◽  
pp. 2174-2190 ◽  
Author(s):  
Jungju Oh ◽  
Jaewon Lee ◽  
Chunxian Piao ◽  
Ji Hoon Jeong ◽  
Minhyung Lee
Keyword(s):  
Gene Therapy ◽  
Ischemic Stroke ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Stroke Therapy ◽  
Self Assembled ◽  
Targeting Peptide ◽  
Inducible Gene

A self-assembled nanoparticle composed of hypoxia-specific anti-RAGE peptide (HSAP), heme oxygenase-1 plasmid (pHO1), and deoxycholate-conjugated polyethylenimine-2k (DP2k) was developed for ischemic stroke therapy.

scholarly journals Novel Fusion Peptide-Mediated siRNA Delivery Using Self-Assembled Nanocomplex

2020 ◽  
Author(s):  
Yeong Chae Ryu ◽  
Kyungah Kim ◽  
Byoung Choul Kim ◽  
Hui-Min David Wang ◽  
Byeong Hee Hwang
Keyword(s):  
Gene Therapy ◽  
Gene Silencing ◽  
Cellular Uptake ◽  
Viral Infections ◽  
Sirna Delivery ◽  
Cellular Membrane ◽  
Fusion Peptides ◽  
Self Assembled

Abstract Background: Gene therapy using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient and safe method of delivering siRNA into cells while maintaining its stability. Thus, we designed novel synergistic fusion peptides, i.e., SPACE and oligoarginine.Results: Among the novel fusion peptides and siRNAs, nanocomplexes have outstanding cellular uptake and gene silencing effect in vitro and high stability and retention effect of siRNAs in vivo. Oligo arginine could attract siRNAs electrostatically to form stable and self-assembled nanocomplexes, and the SPACE peptide could interact with the cellular membrane via hydrogen bonding. Therefore, nanocomplexes using fusion peptides showed improved and evident cellular uptake and gene silencing of Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) via the lipid raft-mediated endocytosis pathway, especially to the HDFn cells of the skin, and all of the fusion peptides were biocompatible. Also, intratumorally injected nanocomplexes had increased stability and retention of siRNAs at the site of the tumor. Conclusions: The new nanocomplex strategy could become a safe and efficient platform for the delivery of siRNAs into cells and tissues to treat various target diseases through gene therapy.

scholarly journals Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles

2020 ◽  
Vol 28 (1) ◽  
pp. 293-303 ◽  
Author(s):  
Da Sun ◽  
Rebecca M. Schur ◽  
Avery E. Sears ◽  
Song-Qi Gao ◽  
Amita Vaidya ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Viral Gene ◽  
Stargardt Disease ◽  
Viral Gene Therapy ◽  
Self Assembled

Antiangiogenic gene therapy delays growth of murine and human pancreatic adenocarcinoma in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A349-A349
Author(s):  
J TSENG ◽  
F FARNEBO ◽  
O KISKER ◽  
C BECKER ◽  
C KUO ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Pancreatic Adenocarcinoma ◽  
Human Pancreatic Adenocarcinoma
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