Molecular weight-dependent antifungal activity and action mode of chitosan against Fulvia fulva (cooke) ciffrri

2010 ◽  
Vol 119 (6) ◽  
pp. 3127-3135 ◽  
Author(s):  
Meiqin Li ◽  
Xiguang Chen ◽  
Jianmin Liu ◽  
Weifen Zhang ◽  
Xuexi Tang
Keyword(s):  
Molecular Weight ◽  
Antifungal Activity ◽  
Action Mode ◽  
Fulvia Fulva

Antifungal activity of different molecular weight chitosans against planktonic cells and biofilm of Sporothrix brasiliensis

2020 ◽  
Vol 143 ◽  
pp. 341-348 ◽  
Author(s):  
Lana Glerieide Silva Garcia ◽  
Glaucia Morgana de Melo Guedes ◽  
Xhaulla Maria Quariguasi Cunha Fonseca ◽  
Waldemiro Aquino Pereira-Neto ◽  
Débora Souza Collares Maia Castelo-Branco ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Antifungal Activity ◽  
Planktonic Cells ◽  
Sporothrix Brasiliensis ◽  
Different Molecular Weight

scholarly journals Antimicrobial Potential of the Alkalophilic Fungus Sodiomyces alkalinus and Selection of Strains–Producers of New Antimicotic Compound

2021 ◽  
Vol 57 (1) ◽  
pp. 86-93
Author(s):  
A. E. Kuvarina ◽  
M. L. Georgieva ◽  
E. A. Rogozhin ◽  
A. B. Kulko ◽  
I. A. Gavryushina ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Antifungal Activity ◽  
Active Compound ◽  
Structural Features ◽  
Antimicrobial Compounds ◽  
Opportunistic Fungi ◽  
Absorption Ratio ◽  
Antibiotic Compounds ◽  
Selection Of

Abstract The ability of alkalophilic micromycetes of the species Sodiomyces alkalinus to produce antimicrobial compounds was studied. As a result of the determination of the spectrum and yield of antibiotic compounds, a promising producer of the antimycotics Sodiomyces alkalinus was selected from the most active strains 8KS17-10. The producer exhibited antifungal activity against opportunistic fungi, as well as pathogenic clinical isolates of molds and yeasts—pathogens of systemic mycoses. The isolated active compound can be attributed to the group of antimicrobial glycopeptides based on the totality of the identified structural features (molecular weight, absorption ratio at certain wavelengths).

scholarly journals Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Andreas Sonesson ◽  
Emma Andersson Nordahl ◽  
Martin Malmsten ◽  
Artur Schmidtchen
Keyword(s):  
Molecular Weight ◽  
Antifungal Activity ◽  
High Molecular Weight ◽  
Clinical Manifestations ◽  
Contact System ◽  
Peptide Fragments ◽  
High Molecular Weight Kininogen ◽  
Fungal Cell ◽  
Cutaneous Infections ◽  
Modified Peptides

In both immunocompromised and immunocompetent patients, Candida and Malassezia are causing or triggering clinical manifestations such as cutaneous infections and atopic eczema. The innate immune system provides rapid responses to microbial invaders, without requiring prior stimulation, through a sophisticated system of antimicrobial peptides (AMPs). High molecular weight kininogen (HMWK) and components of the contact system have previously been reported to bind to Candida and other pathogens, leading to activation of the contact system. A cutaneous Candida infection is characterized by an accumulation of neutrophils, leading to an inflammatory response and release of enzymatically active substances. In the present study we demonstrate that antifungal peptide fragments are generated through proteolytic degradation of HMWK. The recombinant domain 5 (rD5) of HMWK, D5-derived peptides, as well as hydrophobically modified D5-derived peptides efficiently killed Candida and Malassezia. Furthermore, the antifungal activity of modified peptides was studied at physiological conditions. Binding of a D5-derived peptide, HKH20 (His479-His498), to the fungal cell membrane was visualized by fluorescence microscopy. Our data disclose a novel antifungal activity of D5-derived peptides and also show that proteolytic cleavage of HMWK results in fragments exerting antifungal activity. Of therapeutic interest is that structurally modified peptides show an enhanced antifungal activity.

scholarly journals Effect of the molecular weight of chitosan on its antifungal activity against Candida spp. in planktonic cells and biofilm

2018 ◽  
Vol 195 ◽  
pp. 662-669 ◽  
Author(s):  
Lana Glerieide Silva Garcia ◽  
Glaucia Morgana de Melo Guedes ◽  
Maria Lucilene Queiroz da Silva ◽  
Débora Souza Collares Maia Castelo-Branco ◽  
José Júlio Costa Sidrim ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Antifungal Activity ◽  
Planktonic Cells ◽  
Candida Spp

scholarly journals Biodegradable and Biocompatible Silatrane Polymers

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1893
Author(s):  
Vladislav Istratov ◽  
Valerii Vasnev ◽  
Galy Markova
Keyword(s):  
Molecular Weight ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Seed Germination ◽  
Aqueous Solutions ◽  
Surface Activity ◽  
Chemical Structure ◽  
Amphiphilic Polymers ◽  
Hydroxyl Groups ◽  
Hydrophobic Properties

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.

The influence of molecular weight of quaternized chitosan on antifungal activity

2008 ◽  
Vol 71 (4) ◽  
pp. 694-697 ◽  
Author(s):  
Z GUO ◽  
R XING ◽  
S LIU ◽  
Z ZHONG ◽  
X JI ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Antifungal Activity ◽  
Quaternized Chitosan

scholarly journals Expression, Purification and Characterization of Chondroitinase AC II from Marine Bacterium Arthrobacter sp. CS01

Marine Drugs ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 185 ◽  
Author(s):  
Yangtao Fang ◽  
Suxiao Yang ◽  
Xiaodan Fu ◽  
Wancui Xie ◽  
Li Li ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Marine Bacterium ◽  
Specific Activity ◽  
Degradation Products ◽  
Purification And Characterization ◽  
Promising Candidate ◽  
Functional Activities ◽  
Action Mode ◽  
Low Degrees

Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and characterized. ChSase AC II, with a molecular weight of approximately 100 kDa and a specific activity of 18.7 U/mg, showed the highest activity at 37 °C and pH 6.5 and maintained stability at a broad range of pH (5–7.5) and temperature (below 35 °C). The enzyme activity was increased in the presence of Mn2+ and was strongly inhibited by Hg2+. Moreover, the kinetic parameters of ChSase AC II against CS-A, CS-C, and HA were determined. TLC and ESI-MS analysis of the degradation products indicated that ChSase AC II displayed an exolytic action mode and completely hydrolyzed three substrates into oligosaccharides with low degrees of polymerization (DPs). All these features make ChSase AC II a promising candidate for the full use of GAG to produce oligosaccharides.

scholarly journals Silicon-Mediated Accumulation of Flavonoid Phytoalexins in Cucumber

1998 ◽  
Vol 88 (5) ◽  
pp. 396-401 ◽  
Author(s):  
A. Fawe ◽  
M. Abou-Zaid ◽  
J. G. Menzies ◽  
R. R. Bélanger
Keyword(s):  
Molecular Weight ◽  
Disease Resistance ◽  
Antifungal Activity ◽  
Plant Disease Resistance ◽  
Plant Disease ◽  
Conclusive Evidence ◽  
Low Molecular Weight ◽  
Leaf Extracts ◽  
The Family

The controversial role of silicon in plant disease resistance, described mostly as a passive mechanical protection, has been addressed. Conclusive evidence is presented that silicon is involved in the increased resistance of cucumber to powdery mildew by enhancing the antifungal activity of infected leaves. This antifungal activity was attributable to the presence of low-molecular-weight metabolites. One of these metabolites, described here as a phytoalexin, was identified as a flavonol aglycone rhamnetin (3,5,3′,4′-tetrahydroxy-7-O-methoxyflavone). This is the first report of a phytoalexin for this chemical group in the plant kingdom and of a flavonol phytoalexin in cucumber, a chemical defense long believed to be nonexistent in the family Cucurbitaceae. The antifungal activity of leaf extracts was better expressed after acid hydrolysis, extending to another plant species the concept that some phytoalexins are synthesized as glycosylated phytoalexins or their precursors.

The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species

Amino Acids ◽  
2017 ◽  
Vol 50 (2) ◽  
pp. 229-239 ◽  
Author(s):  
Fengjing Jia ◽  
Jiayi Wang ◽  
Jinxiu Peng ◽  
Ping Zhao ◽  
Ziqing Kong ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Action Mode ◽  
In Vivo Antifungal Activity
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