scholarly journals Preparation of low-protein natural rubber latex: Effect of polyethylene glycol

2009 ◽  
Vol 114 (2) ◽  
pp. 806-810 ◽  
Author(s):  
G. Abhilash ◽  
S. Sabharwal ◽  
Abhinav Dubey ◽  
Jose Paul ◽  
Honey John ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Low Protein

BIO-CACO3 FROM RAW EGGSHELL AS ADDITIVE IN NATURAL RUBBER LATEX GLOVE FILMS

2019 ◽  
Vol 92 (3) ◽  
pp. 558-577
Author(s):  
Nuchnapa Tangboriboon ◽  
Rujika Takkire ◽  
Watchara Sangwan ◽  
Sairung Changkhamchom ◽  
Anuvat Sirivat
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Natural Rubber ◽  
Protein Content ◽  
Natural Rubber Latex ◽  
Film Surface ◽  
Rubber Latex ◽  
Elongation At Break ◽  
Latex Glove ◽  
Low Protein

ABSTRACT Raw hen eggshell powder, a calcium carbonate source, was used as a biofiller in the natural rubber latex compound and latex glove film formation via dipping process. The powder was anticipated to improve the physical (smoothness and thickness of film) and mechanical properties (tensile strength and elongation at break) of latex film and to reduce the extractable protein content on film surface. Eggshell powder ground by a rapid mill was fine particles of approximately 37.48 μm in diameter, suitable for homogeneous and compatible addition into the natural rubber latex compound. Dipping hand mold into the natural rubber latex compound with 50 wt% eggshell added was the best formula to obtain a smooth, clear, thin film surface, with the tensile strength of 23.24 ± 0.745 MPa and the highest elongation at break of 723.99 ± 14.60%, along with a low protein content, a dense film without water leakage, and with a good contact angle. The natural rubber latex glove film possessed good physical-mechanical properties and a low protein content as the results of the raw eggshell powder added as a biofiller.

scholarly journals ADJUSTING THE LOW MOLECULAR WEIGHT OF HYDROXYETHYL CELLULOSE AND APPLIED TO EXTRACT PROTEINS IN NATURAL RUBBER LATEX

2021 ◽  
Vol 59 (5) ◽  
Author(s):  
Lai Thi Kim Dung ◽  
Le Nghiem Anh Tuan ◽  
Bui Duy Du
Keyword(s):  
Natural Rubber ◽  
Protein Content ◽  
Natural Rubber Latex ◽  
Hydroxyethyl Cellulose ◽  
Low Molecular Weight ◽  
Rubber Latex ◽  
H2o2 Treatment ◽  
Medical Products ◽  
Low Protein ◽  
Allergenic Proteins

Natural rubber latex (NRL) with “low protein content” is regarded as less allergenic latex for medical gloves, medical products, condoms, etc. Therefore, this study was conducted to strengthen the fundamental approach of making “low protein NRL” via oligosaccharide hydroxyl ethyl cellulose (oligoHEC) treatment. OligoHEC (Mw ~10,000 g/mol) is degradation product of HEC (Mw ~90,000 g/mol) by 1.5% H2O2 treatment combined with hydrothermal at temperature for 30 minutes at 121°C, pressurized rate of 0.38 mPa by autoclave equipment. OligoHECs were employed to form electrical bonds with the proteins. The target of this study is protein content of NRL ≤ 50 µg/g of rubber, we surveyed the effect of oligoHEC treatment towards the solution proteins content of NRL. Results show that oligoHEC at low concentration (0.25%) effectively extracted the proteins molecules. Interestingly, allergenic proteins content of NRL serum was decreased proportionally (< 50 µg/g of rubber) with the upsurge of oligoHEC concentration, suggesting deactivation of allergenic. These preliminary results indicate a potential approach to produce low allergenic risk NRL products with adding of oligoHEC

Low Protein Natural Rubber Latex - Based Polymer Blends for Transdermal Patches of Mefenamic Acid

2020 ◽  
Vol 859 ◽  
pp. 34-38
Author(s):  
Jirapornchai Suksaeree ◽  
Wiwat Pichayakorn ◽  
Patsakorn Siripornpinyo ◽  
Somruethai Chaiprasit ◽  
Pattwat Maneewattanapinyo
Keyword(s):  
Natural Rubber ◽  
Mefenamic Acid ◽  
Hydroxypropyl Methylcellulose ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Low Protein ◽  
Transdermal Patches ◽  
Crystallization Inhibitor ◽  
Pass Metabolism

Transdermal patches are attraction and acceptance for the patient due to avoid first-pass metabolism, easy to administer and removal, allows rapid termination of treatment if required etc. Low protein natural rubber latex (LPNRL) is a natural polymer that removed the allergic protein from fresh NRL prepared by treatment with proteolytic enzyme and centrifuging process. LPNRL is used for medical skin applications with the non-allergenic product. The objective of this research aimed to prepare the mefenamic acid – loaded transdermal patches made from LPNRL blended with either hydroxypropyl methylcellulose (HPMC) or polyvinyl alcohol (PVA), glycerin and polyvinylpyrrolidone were used as plasticizer and crystallization inhibitor, respectively. The moisture uptake and swelling ratio showed the increment value after either HPMC or PVA was blended in LPNRL because of the increment of their hydrophilicity. These patches showed the homogeneous films that observed by the researcher. The in vitro release showed a faster release rate after either HPMC or PVA was blended in LPNRL. It was concluded that mefenamic acid – loaded transdermal patches could be prepared by using LPNRL blended with either HPMC or PVA as matrix film former could provide an increased and controlled release of the drug. Moreover, it was safe to apply on the skin as did not cause irritation.

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