Controlled release of naproxen from sodium alginate and poly(vinyl alcohol)/sodium alginate blend beads crosslinked with glutaraldehyde

2009 ◽  
Vol 112 (4) ◽  
pp. 2057-2065 ◽  
Author(s):  
Oya Şanlı ◽  
Ebru Kondolot Solak
Keyword(s):  
Controlled Release ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol

Preparation of sodium alginate/poly(vinyl alcohol) blend microspheres for controlled release applications

2011 ◽  
Vol 125 (1) ◽  
pp. 555-561 ◽  
Author(s):  
B. Yerri Swamy ◽  
C. Venkata Prasad ◽  
C. L. N. Reddy ◽  
P. Sudhakara ◽  
Ildoo Chung ◽  
...  
Keyword(s):  
Controlled Release ◽  
Sodium Alginate ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol

scholarly journals Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2381
Author(s):  
Katarzyna Bialik-Wąs ◽  
Ewelina Królicka ◽  
Dagmara Malina
Keyword(s):  
Sodium Alginate ◽  
Aqueous Extract ◽  
Vinyl Alcohol ◽  
Crosslinking Agent ◽  
Echinacea Purpurea ◽  
Poly Vinyl Alcohol ◽  
Spectra Analysis ◽  
Natural Origin ◽  
Glycol Diacrylate ◽  
Soxhlet Apparatus

Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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