Preparation and characterization of macroporous poly(2-hydroxyethyl methacrylate)-based biomaterials: Water sorption property andin vitro blood compatibility

2007 ◽  
Vol 104 (3) ◽  
pp. 1559-1571 ◽  
Author(s):  
A. K. Bajpai ◽  
Sanjana Kankane
2008 ◽  
Vol 396-398 ◽  
pp. 465-468
Author(s):  
Wei Wang ◽  
Zhen Li ◽  
Li Li

Magnetic nanocomposite films of the Fe3O4/pHEMA were prepared by dispersing the Fe3O4 nanoparticles into the HEMA monomer before they were polymerized. The resultant nanocomposite films were characterized by Fourier transform infrared (FT-IR) and the vibrating sample magnetometer (VSM). The swelling behavies and the hemolytic ratios of the filmes were also investigated in this work.The equilibrium swelling ratio decreased with the increase of the amount of nanoparticles. The nanocomposite films had a clear superparamagnetic behavior because of the addition of nanoparticles. The hemolytic ratios were all lower than 5%, which indicated that the nanocomposites films had the good blood compatibility and can be used in the biomedical field


Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2449
Author(s):  
Beata Kaczmarek-Szczepańska ◽  
Olha Mazur ◽  
Marta Michalska-Sionkowska ◽  
Krzysztof Łukowicz ◽  
Anna Maria Osyczka

In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.


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