Rheological properties and drug release characteristics of pH-responsive hydrogels

2004 ◽  
Vol 94 (5) ◽  
pp. 2057-2064 ◽  
Author(s):  
Tejraj M. Aminabhavi ◽  
Sunil A. Agnihotri ◽  
B. Vijaya Kumar Naidu
Keyword(s):  
Drug Release ◽  
Rheological Properties ◽  
Ph Responsive ◽  
Responsive Hydrogels

Photo-cross-linked biodegradable thermo- and pH-responsive hydrogels for controlled drug release

2011 ◽  
Vol 123 (5) ◽  
pp. 2923-2932 ◽  
Author(s):  
Changwen Zhao ◽  
Pan He ◽  
Chunsheng Xiao ◽  
Xiaoye Gao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Responsive Hydrogels

scholarly journals Biodegradable pH-responsive hydrogels for controlled dual-drug release

2018 ◽  
Vol 6 (3) ◽  
pp. 510-517 ◽  
Author(s):  
Liang Xu ◽  
Linzi Qiu ◽  
Yang Sheng ◽  
Yixin Sun ◽  
Linhong Deng ◽  
...  
Keyword(s):  
Drug Release ◽  
Ph Responsive ◽  
Biodegradable Hydrogels ◽  
Responsive Hydrogels ◽  
Dual Drug

pH-Responsive biodegradable hydrogels based on NIPAM/AA and a PLLA/PEG macro-crosslinker demonstrated pH mediated differential release of doxorubicin and tetracycline.

Chitosan-based interpolymeric pH-responsive hydrogels forin vitro drug release

2006 ◽  
Vol 103 (5) ◽  
pp. 2864-2874 ◽  
Author(s):  
M. Y. Abdelaal ◽  
E. A. Abdel-Razik ◽  
E. M. Abdel-Bary ◽  
I. M. El-Sherbiny
Keyword(s):  
Drug Release ◽  
Ph Responsive ◽  
Responsive Hydrogels

scholarly journals A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release

2018 ◽  
Vol 9 (29) ◽  
pp. 4063-4072 ◽  
Author(s):  
Yan Chen ◽  
Yuting Gao ◽  
Lucília P. da Silva ◽  
Rogério P. Pirraco ◽  
Mengdi Ma ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Drug Release ◽  
Sustained Release ◽  
Small Molecule ◽  
Drug Carrier ◽  
Ph Responsive ◽  
General Drug ◽  
Model Drug ◽  
Molecule Model ◽  
Responsive Hydrogels

The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB).

Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release

Polymer ◽  
2009 ◽  
Vol 50 (18) ◽  
pp. 4308-4316 ◽  
Author(s):  
Changwen Zhao ◽  
Xiuli Zhuang ◽  
Pan He ◽  
Chunsheng Xiao ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Responsive Hydrogels

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 169-181 ◽  
Author(s):  
Yanan Tan ◽  
Yun Zhu ◽  
Yue Zhao ◽  
Lijuan Wen ◽  
Tingting Meng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Alkaline Ph ◽  
Ph Responsive
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