Sampling and analysis in flow: the keys to smarter, more controllable and sustainable fine‐chemical manufacturing

2021 ◽  
Author(s):  
Michael G Organ ◽  
Mathieu A. Morin ◽  
Wenyao (Peter) Zhang ◽  
Debasis Mallik
Keyword(s):  
Fine Chemical ◽  
Chemical Manufacturing

Sampling and analysis in flow: the keys to smarter, more controllable and sustainable fine‐chemical manufacturing

2021 ◽  
Author(s):  
Michael G Organ ◽  
Mathieu A. Morin ◽  
Wenyao (Peter) Zhang ◽  
Debasis Mallik
Keyword(s):  
Fine Chemical ◽  
Chemical Manufacturing

Electrochemical treatment of the effluent of a fine chemical manufacturing plant

2006 ◽  
Vol 138 (1) ◽  
pp. 173-181 ◽  
Author(s):  
P. Cañizares ◽  
R. Paz ◽  
J. Lobato ◽  
C. Sáez ◽  
M.A. Rodrigo
Keyword(s):  
Electrochemical Treatment ◽  
Manufacturing Plant ◽  
Fine Chemical ◽  
Chemical Manufacturing

scholarly journals A Regenerative Business Model with Flexible, Modular and Scalable Processes in A Post-Covid Era: The Case of The Spinning Mesh Disc Reactor (SMDR)

2021 ◽  
Vol 13 (12) ◽  
pp. 6944
Author(s):  
Emma Anna Carolina Emanuelsson ◽  
Aurelie Charles ◽  
Parimala Shivaprasad
Keyword(s):  
Business Model ◽  
Low Cost ◽  
Sustainable Manufacturing ◽  
Sustainable Business ◽  
Capital Costs ◽  
Implementing Change ◽  
Chemical Manufacturing ◽  
Manufacturing Techniques ◽  
Flexible Operation

With stringent environmental regulations and a new drive for sustainable manufacturing, there is an unprecedented opportunity to incorporate novel manufacturing techniques. Recent political and pandemic events have shown the vulnerability to supply chains, highlighting the need for localised manufacturing capabilities to better respond flexibly to national demand. In this paper, we have used the spinning mesh disc reactor (SMDR) as a case study to demonstrate the path forward for manufacturing in the post-Covid world. The SMDR uses centrifugal force to allow the spread of thin film across the spinning disc which has a cloth with immobilised catalyst. The modularity of the design combined with the flexibility to perform a range of chemical reactions in a single equipment is an opportunity towards sustainable manufacturing. A global approach to market research allowed us to identify sectors within the chemical industry interested in novel reactor designs. The drivers for implementing change were identified as low capital cost, flexible operation and consistent product quality. Barriers include cost of change (regulatory and capital costs), limited technical awareness, safety concerns and lack of motivation towards change. Finally, applying the key features of a Sustainable Business Model (SBM) to SMDR, we show the strengths and opportunities for SMDR to align with an SBM allowing for a low-cost, sustainable and regenerative system of chemical manufacturing.

scholarly journals Electrochemical reduction of acetonitrile to ethylamine

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Rong Xia ◽  
Dong Tian ◽  
Shyam Kattel ◽  
Bjorn Hasa ◽  
Haeun Shin ◽  
...  
Keyword(s):  
Computational Study ◽  
Building Blocks ◽  
Primary Amines ◽  
Hydrogen Electrode ◽  
Faradaic Efficiency ◽  
Fossil Energy ◽  
Chemical Manufacturing ◽  
Stable Performance ◽  
Temperature And Pressure ◽  
Partial Current

AbstractElectrifying chemical manufacturing using renewable energy is an attractive approach to reduce the dependence on fossil energy sources in chemical industries. Primary amines are important organic building blocks; however, the synthesis is often hindered by the poor selectivity because of the formation of secondary and tertiary amine byproducts. Herein, we report an electrocatalytic route to produce ethylamine selectively through an electroreduction of acetonitrile at ambient temperature and pressure. Among all the electrocatalysts, Cu nanoparticles exhibit the highest ethylamine Faradaic efficiency (~96%) at −0.29 V versus reversible hydrogen electrode. Under optimal conditions, we achieve an ethylamine partial current density of 846 mA cm−2. A 20-hour stable performance is demonstrated on Cu at 100 mA cm−2 with an 86% ethylamine Faradaic efficiency. Moreover, the reaction mechanism is investigated by computational study, which suggests the high ethylamine selectivity on Cu is due to the moderate binding affinity for the reaction intermediates.

scholarly journals Refactoring of a synthetic raspberry ketone pathway with EcoFlex

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Simon J. Moore ◽  
Yonek B. Hleba ◽  
Sarah Bischoff ◽  
David Bell ◽  
Karen M. Polizzi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Synthetic Biology ◽  
Combinatorial Libraries ◽  
Value Added ◽  
Microtiter Plate ◽  
Fine Tuning ◽  
Golden Gate ◽  
E Coli ◽  
Fine Chemical ◽  
Raspberry Ketone

Abstract Background  A key focus of synthetic biology is to develop microbial or cell-free based biobased routes to value-added chemicals such as fragrances. Originally, we developed the EcoFlex system, a Golden Gate toolkit, to study genes/pathways flexibly using Escherichia coli heterologous expression. In this current work, we sought to use EcoFlex to optimise a synthetic raspberry ketone biosynthetic pathway. Raspberry ketone is a high-value (~ £20,000 kg−1) fine chemical farmed from raspberry (Rubeus rubrum) fruit. Results  By applying a synthetic biology led design-build-test-learn cycle approach, we refactor the raspberry ketone pathway from a low level of productivity (0.2 mg/L), to achieve a 65-fold (12.9 mg/L) improvement in production. We perform this optimisation at the prototype level (using microtiter plate cultures) with E. coli DH10β, as a routine cloning host. The use of E. coli DH10β facilitates the Golden Gate cloning process for the screening of combinatorial libraries. In addition, we also newly establish a novel colour-based phenotypic screen to identify productive clones quickly from solid/liquid culture. Conclusions  Our findings provide a stable raspberry ketone pathway that relies upon a natural feedstock (L-tyrosine) and uses only constitutive promoters to control gene expression. In conclusion we demonstrate the capability of EcoFlex for fine-tuning a model fine chemical pathway and provide a range of newly characterised promoter tools gene expression in E. coli.

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