scholarly journals α‐Arylation of Carbonyl Compounds through Oxidative C−C Bond Activation

2019 ◽  
Vol 58 (29) ◽  
pp. 9816-9819 ◽  
Author(s):  
Jing Li ◽  
Adriano Bauer ◽  
Giovanni Di Mauro ◽  
Nuno Maulide
Keyword(s):  
Carbonyl Compounds ◽  
Bond Activation

Preparation of hydrido [CNC]-pincer cobalt complexes via selective C–H/C–F bond activation and their catalytic performances

2018 ◽  
Vol 42 (19) ◽  
pp. 15578-15586 ◽  
Author(s):  
Fei Yang ◽  
Yangyang Wang ◽  
Faguan Lu ◽  
Shangqing Xie ◽  
Xinghao Qi ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Bond Activation ◽  
Cobalt Complexes ◽  
Catalytic Performances

[CNC]-pincer Co hydrides were synthesized via selective C–H/C–F activation and catalyzed hydrosilylation of carbonyl compounds.

Transition-metal-catalyzed direct β-functionalization of simple carbonyl compounds

2014 ◽  
Vol 1 (7) ◽  
pp. 838-842 ◽  
Author(s):  
Guobing Yan ◽  
Arun Jyoti Borah
Keyword(s):  
Transition Metal ◽  
Carbonyl Compounds ◽  
Bond Activation ◽  
Active Area ◽  
Synthetic Chemistry ◽  
Chemical Transformations ◽  
Recent Advances ◽  
Direct Functionalization ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Chemical transformations via catalytic C–H bond activation have been established as one of the most powerful tools in organic synthetic chemistry. Transition-metal-catalyzed direct functionalization of β-C(sp3)–H bonds of carbonyl compounds has been developed in recent years. This highlight will focus on recent advances in this active area and their mechanisms are also discussed.

Rhenium-catalyzed synthesis of indene derivatives via C-H bond activation

2008 ◽  
Vol 80 (5) ◽  
pp. 1149-1154 ◽  
Author(s):  
Yoichiro Kuninobu ◽  
Yuta Nishina ◽  
Atsushi Kawata ◽  
Makoto Shouho ◽  
Kazuhiko Takai
Keyword(s):  
Carbonyl Compounds ◽  
Bond Activation ◽  
Reductive Elimination ◽  
Aromatic Ketones ◽  
Rhenium Complex ◽  
Aromatic Imines ◽  
Catalyzed Reactions ◽  
Nucleophilic Cyclization

Rhenium complex, [ReBr(CO)3(thf)]2-catalyzed reactions between aromatic imines and either acetylenes or α,β-unsaturated carbonyl compounds gave indene derivatives in good to excellent yields. These reactions proceed via C-H bond activation, insertion of acetylenes or α,β-unsaturated carbonyl compounds, intramolecular nucleophilic cyclization, and reductive elimination. Indene derivatives were also obtained from aromatic ketones and α,β-unsaturated carbonyl compounds in the presence of catalytic amounts of the rhenium complex and p-anisidine. Sequential ruthenium-catalyzed hydroamination of aromatic acetylenes with anilines, and rhenium-catalyzed reactions of the formed aromatic ketimines with α,β-unsaturated carbonyl compounds also provided indene derivatives.

Synthetic approaches toward diversely substituted 1,2,2-triarylethanones

2021 ◽  
Vol 25 ◽  
Author(s):  
Rodrigo Abonia ◽  
Oscar Montoya
Keyword(s):  
Carbonyl Compounds ◽  
Bond Activation ◽  
Building Blocks ◽  
Biologically Active ◽  
Carbon Carbon Bond ◽  
Key Points ◽  
Carbon Carbon Bonds ◽  
Reported Data ◽  
Synthetic Approaches ◽  
Free Metal

: Carbon–carbon bond formation is the essence of organic synthesis, and for that, many strategies have been developed to accomplish this goal. Several of these strategies are conducted to form diverse structures bearing the α,α-diarylcarbonyl motif, in form of 1,2,2-triarylethanones, which are unities present in a number of natural products and biologically active compounds.These privileged carbonyl compounds have been used as building blocks or intermediates for the synthesis of dibenzo[a,c]phenanthridines, analogues of biologically active benzo[c]phenanthridine alkaloids, as well as, a useful synthon for Droloxifene and remarkably for Tamoxifen, the most widely used drug for the treatment of breast cancer. Focusing on the literature progress since 2000 to 2020 and considering the synthetic and biologically value of the aforementioned carbonyl compounds, the present review explores the diverse metal-free, metal-mediated, C–H bond activation, α-monoarylation, α,α-diarylation, umpolung processes, N-heterocyclic carbene (NHC), deoxygenation, among others,synthetic approaches directed to the synthesis of 1,2,2-triarylethanone derivatives. Moreover, several of their mechanistic proposals are also briefly discussed in this review. In view that most of these strategies are accompanied of carbon–carbon bonds formation through ketone-based α-arylation processes,the reported data are organized into concise Tables/Schemes to facilitate comparison, and to underscore the key points of this review.

Reactivity of boraguanidinato germylenes toward carbonyl compounds and isocyanides: C–O, C–F and C–N bond activation

2020 ◽  
Vol 49 (15) ◽  
pp. 4869-4877 ◽  
Author(s):  
Jiří Böserle ◽  
Roman Jambor ◽  
Aleš Růžička ◽  
Milan Erben ◽  
Libor Dostál
Keyword(s):  
Carbonyl Compounds ◽  
Bond Activation ◽  
Chemical Bonds

The titled germylene was shown to be able to activate various chemical bonds (C–N, C–F or CO) depending on the substrate used.

C−F Bond Activation in Fluorinated Carbonyl Compounds by Chromium Monocations in the Gas Phase

2003 ◽  
Vol 22 (2) ◽  
pp. 218-225 ◽  
Author(s):  
Ulf Mazurek ◽  
Konrad Koszinowski ◽  
Helmut Schwarz
Keyword(s):  
Gas Phase ◽  
Carbonyl Compounds ◽  
Bond Activation
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