scholarly journals Light‐Controlled Orthogonal Covalent Bond Formation at Two Different Wavelengths

2019 ◽  
Vol 58 (22) ◽  
pp. 7470-7474 ◽  
Author(s):  
Jan P. Menzel ◽  
Florian Feist ◽  
Bryan Tuten ◽  
Tanja Weil ◽  
James P. Blinco ◽  
...  
Keyword(s):  
Bond Formation ◽  
Covalent Bond ◽  
Covalent Bond Formation

scholarly journals Chemical Investigations Into the Biosynthesis of the Gymnastatin and Dankastatin Alkaloids

2021 ◽  
Author(s):  
Bingqi Tong ◽  
Bridget Belcher ◽  
Daniel Nomura ◽  
Thomas Maimone
Keyword(s):  
Natural Products ◽  
Protein Function ◽  
Bond Formation ◽  
Covalent Bond ◽  
Fungal Strain ◽  
Fertile Ground ◽  
Covalent Bond Formation

Electrophilic natural products have provided fertile ground for understanding how nature inhibits protein function using covalent bond formation. The fungal strain Gymnascella dankaliensis has provided an especially interesting collection of...

Material Adhesion through Direct Covalent Bond Formation Assisted by Noncovalent Interactions

2021 ◽  
Author(s):  
Motofumi Osaki ◽  
Tomoko Sekine ◽  
Hiroyasu Yamaguchi ◽  
Yoshinori Takashima ◽  
Akira Harada
Keyword(s):  
Noncovalent Interactions ◽  
Bond Formation ◽  
Covalent Bond ◽  
Covalent Bond Formation

scholarly journals Mechanism of Covalent Binding of Ibrutinib to Bruton’s Tyrosine Kinase revealed by QM/MM Calculations

2020 ◽  
Author(s):  
Angus Voice ◽  
Gary Tresadern ◽  
Rebecca Twidale ◽  
Herman Van Vlijmen ◽  
Adrian Mulholland
Keyword(s):  
Tyrosine Kinase ◽  
Covalent Binding ◽  
Bond Formation ◽  
Covalent Bond ◽  
Covalent Modification ◽  
Mechanistic Study ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Covalent Inhibitors ◽  
Covalent Bond Formation

<p>Ibrutinib is the first covalent inhibitor of Bruton’s tyrosine kinase (BTK) to be used in the treatment of B-cell cancers. Understanding the mechanism of covalent inhibition is crucial for the design of safer and more selective covalent inhibitors that target BTK. There are questions surrounding the precise mechanism of covalent bond formation in BTK as there is no appropriate active site residue that can act as a base to deprotonate the cysteine thiol prior to covalent bond formation. To address this, we have investigated several mechanistic pathways of covalent modification of C481 in BTK by ibrutinib using QM/MM reaction simulations. The lowest energy pathway we identified involves a direct proton transfer from C481 to the acrylamide warhead in ibrutinib, followed by covalent bond formation to form an enol intermediate. There is a subsequent rate-limiting keto-enol tautomerisation step (DG<sup>‡</sup>=10.5 kcal mol<sup>-1</sup>) to reach the inactivated BTK/ibrutinib complex. Our results represent the first mechanistic study of BTK inactivation by ibrutinib to consider multiple mechanistic pathways. These findings should aid in the design of covalent drugs that target BTK and related proteins. </p>

Supramolecular Assembly-Enabled Homochiral Polymerization of Short (dA)n Oligonucleotides

2021 ◽  
Author(s):  
Sreejith Mangalath ◽  
Suneesh C Karunakaran ◽  
Gary Newnam ◽  
Gary Schuster ◽  
Nicholas Hud
Keyword(s):  
Supramolecular Chemistry ◽  
Bond Formation ◽  
Supramolecular Assembly ◽  
Covalent Bond ◽  
Complex Mixtures ◽  
Covalent Bond Formation

A goal of supramolecular chemistry is to create covalent polymers of precise composition and stereochemistry from complex mixtures by the reversible assembly of specific monomers prior to covalent bond formation....

Photoinduced Intramolecular Covalent Bond Formation in Structurally Rigid -Bpa-(spacer)-Met Hexapeptides

2009 ◽  
pp. 449-450
Author(s):  
Alessandro Moretto ◽  
Simona Oancea ◽  
Fernando Formaggio ◽  
Claudio Toniolo ◽  
Laurence A. Huck ◽  
...  
Keyword(s):  
Bond Formation ◽  
Covalent Bond ◽  
Covalent Bond Formation

Direct covalent bond formation between materials using copper(i)-catalyzed azide alkyne cycloaddition reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (69) ◽  
pp. 56130-56135 ◽  
Author(s):  
Tomoko Sekine ◽  
Yoshinori Takashima ◽  
Akira Harada
Keyword(s):  
Bond Formation ◽  
Covalent Bond ◽  
Polymeric Materials ◽  
Cycloaddition Reactions ◽  
Inorganic Glass ◽  
Glass Substrates ◽  
Cuaac Reaction ◽  
Covalent Bond Formation

Bondings between polymeric materials and between polymeric materials and inorganic glass substrates have been achieved using the CuAAC reaction.

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